共同研究実績

共同利用・共同研究による業績（2016年以降）

2023年度

  • The B domain of protein A retains residual structures in 6 M guanidinium chloride as revealed by hydrogen/deuterium-exchange NMR spectroscopy.
    Yanaka S, Yagi-Utsumi M, Kato K, Kuwajima K.
    Protein Sci. 2023 Mar;32(3):e4569. doi: 10.1002/pro.4569.

  • Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages.
    Sawai Y, Suzuki Y, Asagiri M, Hida S, Kondo R, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
    Am J Physiol Cell Physiol. 2024 Jan 1;326(1):C125-C142. doi: 10.1152/ajpcell.00303.2023. Epub 2023 Nov 13.

  • Improved drug transfer into brain tissue via the “nose-to-brain” approach using suspension or powder formulations based on the amorphous solid dispersion technique.
    Suwabe S, Tagami T, Ogawa K, Ozeki T.
    Eur J Pharm Biopharm. 2023 Apr;185:137-147. doi: 10.1016/j.ejpb.2023.02.012. Epub 2023 Feb 24.

  • Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation, and proteasomal degradation.
    Tokugawa M, Inoue Y, Aoki H, Miyajima C, Ishiuchi K, Tsurumi K, Kujirai C, Morishita D, Matsuno M, Mizukami H, Ri M, Iida S, Makino T, Aoyama M, Hayashi H.
    J Biochem. 2023 Nov 8:mvad085. doi: 10.1093/jb/mvad085. Online ahead of print.

  • High preoperative serum strontium levels increase the risk of acute kidney injury after cardiopulmonary bypass.
    Tomita N, Hotta Y, Ito H, Naiki-Ito A, Matsuta K, Yamamoto Y, Ohashi K, Hayakawa T, Sanagawa A, Horita Y, Kondo M, Kataoka T, Takahashi S, Sobue K, Kimura K.
    Clin Exp Nephrol. 2023 Apr;27(4):382-391. doi: 10.1007/s10157-022-02314-w. Epub 2023 Jan 23.

  • Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration.
    Sakakibara Y, Yamashiro R, Chikamatsu S, Hirota Y, Tsubokawa Y, Nishijima R, Takei K, Sekiya M, Iijima KM.
    iScience. 2023 Jan 13;26(2):105968. doi: 10.1016/j.isci.2023.105968. eCollection 2023 Feb 17.

  • Photoinduced NO-release from polymer dots doped with an Ir(III) complex and N-methyl-N-nitroso-4-aminophenol.
    Saitoh D, Suzuki A, Ieda N, Liu Z, Osakada Y, Fujitsuka M, Kawaguchi M, Nakagawa H.
    Org Biomol Chem. 2023 Apr 5;21(14):2983-2989. doi: 10.1039/d3ob00047h.

  • The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
    Yagi-Utsumi M, Itoh SG, Okumura H, Yanagisawa K, Kato K, Nishimura K.
    ACS Chem Neurosci. 2023 Aug 2;14(15):2648-2657. doi: 10.1021/acschemneuro.3c00192. Epub 2023 Jul 23.

  • Successful Noninvasive Respiratory Management of an Infant with Bilateral Choanal Atresia and a Supernumerary Nostril Located on the Columella by a Mouthpiece: A Case Report.
    Nakamura N, Kakita H, Takagi M, Asai S, Asai T, Mori M, Takeshita S, Ueda H, Aoyama M, Kishimoto M, Ito K, Yamada Y.
    Am J Case Rep. 2023 Jun 26;24:e939642. doi: 10.12659/AJCR.939642.

  • Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
    Ishida M, Yamamura A, Fujiwara M, Amano T, Ota M, Hikawa Y, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
    J Pharmacol Sci. 2023 Oct;153(2):84-88. doi: 10.1016/j.jphs.2023.08.001. Epub 2023 Aug 10.

  • Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.
    Fukuda N, Toriuchi K, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Neurochem Res. 2023 Dec 19. doi: 10.1007/s11064-023-04075-8. Online ahead of print.

  • A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila.
    Kobayashi R, Nakane S, Tomita J, Funato H, Yanagisawa M, Kume K.
    Front Neurosci. 2023 Aug 17;17:1181555. doi: 10.3389/fnins.2023.1181555. eCollection 2023.

  • Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate.
    Hisamatsu Y, Cheng F, Yamamoto K, Takase H, Umezawa N, Higuchi T.
    Nanoscale. 2023 Feb 16;15(7):3177-3187. doi: 10.1039/d2nr05756e.

  • Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve-Guided Vancomycin Dosing: A Short Communication.
    Horita Y, Asaoka M, Iida M, Kato H, Wachino C, Mitamura K, Ohashi K, Mimura Y, Hotta Y, Kataoka T, Nakamura A, Kimura K.
    Ther Drug Monit. 2023 Apr 1;45(2):245-250. doi: 10.1097/FTD.0000000000001026.

  • Changes in zinc and manganese concentrations in cisplatin-induced acute kidney injury
    Yamamoto Y, Hotta Y, Tomita N, Naiki-Ito A, Kitagawa A, Kuboshiki U, Hagita T, Noda M, Sanagawa A, Kataoka T, Kondo M, Furukawa-Hibi Y, Takahashi S, Kimura K.
    Biochem Biophys Rep. 2023 Jan 13;33:101422. doi: 10.1016/j.bbrep.2023.101422. eCollection 2023 Mar.

  • Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins.
    Yanaka S, Yogo R, Yagi H, Onitsuka M, Wakaizumi N, Yamaguchi Y, Uchiyama S, Kato K.
    Front Immunol. 2023 Jan 25;14:1090898. doi: 10.3389/fimmu.2023.1090898. eCollection 2023.

  • Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.
    Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.
    J Pharmacol Sci. 2023 Nov;153(3):153-160. doi: 10.1016/j.jphs.2023.08.008. Epub 2023 Sep 1.

  • AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway.
    Owaki R, Aoki H, Toriuchi K, Inoue Y, Hayashi H, Takeshita S, Kakita H, Yamada Y, Aoyama M.
    Exp Cell Res. 2023 Nov 1;432(1):113784. doi: 10.1016/j.yexcr.2023.113784. Epub 2023 Sep 18.

  • Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time.
    Sakai Y, Matsumura M, Iwao T, Matsunaga T.
    In Vitro Cell Dev Biol Anim. 2023 Sep;59(8):606-614. doi: 10.1007/s11626-023-00805-y. Epub 2023 Sep 8.

  • Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils.
    Kitano T, Togawa K, Takemori J, Motoki Y, Kishida K, Itoh S, Takamoto M, Taki S, Hida S.
    Genes Cells. 2023 Mar;28(3):226-236. doi: 10.1111/gtc.13007. Epub 2023 Jan 27.

  • Effects of Hovenia dulcis fruit and peduncle extract on alcohol metabolism.
    Niiya M, Shimato Y, Ohno T, Makino T.
    J Ethnopharmacol. 2024 Mar 1;321:117541. doi: 10.1016/j.jep.2023.117541. Epub 2023 Dec 3.

  • Circadian control of sleep-related neuronal activity in lizards.
    Yamaguchi ST, Hatori S, Kotake KT, Zhou Z, Kume K, Reiter S, Norimoto H.
    PNAS Nexus. 2023 Dec 29;3(1):pgad481. doi: 10.1093/pnasnexus/pgad481. eCollection 2024 Jan.

  • Three-dimensional analysis of the intracellular architecture by scanning electron microscopy.
    Koga D, Kusumi S, Yagi H, Kato K.
    Microscopy (Oxf). 2023 Nov 1:dfad050. doi: 10.1093/jmicro/dfad050. Online ahead of print.

  • Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
    Cho C, Ganser C, Uchihashi T, Kato K, Song JJ.
    Commun Biol. 2023 Sep 28;6(1):993. doi: 10.1038/s42003-023-05373-1.

  • Clustering of charged colloidal particles in the microgravity environment of space.
    Miki H, Ishigami T, Yamanaka J, Okuzono T, Toyotama A, Mata J, Komazawa H, Takeda Y, Minami M, Fujita M, Doi M, Higuchi T, Takase H, Adachi S, Sakashita T, Shimaoka T, Nagai M, Watanabe Y, Fukuyama S.
    NPJ Microgravity. 2023 Apr 29;9(1):33. doi: 10.1038/s41526-023-00280-5.

  • Efficacy of a Red-Light Controllable Nitric Oxide Releaser for Neurogenic Erectile Dysfunction: A Study Using a Rat Model of Cavernous Nerve Injury.
    Mori T, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K.
    World J Mens Health. 2023 Oct;41(4):909-919. doi: 10.5534/wjmh.220146. Epub 2023 Jan 3.

  • Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid.
    Alghurabi H, Jassim Muhammad H, Tagami T, Ogawa K, Ozeki T.
    Int J Pharm. 2023 Dec 15;648:123597. doi: 10.1016/j.ijpharm.2023.123597. Epub 2023 Nov 10.

  • The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic Agent.
    Izumi K, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Curr Cancer Drug Targets. 2023;23(11):837-842. doi: 10.2174/1568009623666230522113645.

  • GNRI Sustainability during One Cycle of First-Line Chemotherapy as a Prognostic Indicator in Patients with Metastatic Urothelial Carcinoma.
    Sugiyama Y, Naiki T, Tasaki Y, Mimura Y, Etani T, Noda Y, Nozaki S, Shimizu N, Banno R, Nagai T, Isobe T, Ando R, Moritoki Y, Kataoka T, Odagiri K, Aoki M, Gonda M, Yasui T, Hibi Y.
    Oncology. 2023;101(4):224-233. doi: 10.1159/000529203. Epub 2023 Jan 23.

  • Quantitative analysis of therapeutic antibody interactions with Fcγ receptors using high-speed atomic force microscopy.
    Yanaka S, Watanabe H, Yogo R, Kongsema M, Kondo S, Yagi H, Uchihashi T, Kato K.
    Biol Pharm Bull. 2023 Dec 22. doi: 10.1248/bpb.b23-00751. Online ahead of print.

  • The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons.
    Oya S, Korogi K, Kohno T, Tsuiji H, Danylchuk DI, Klymchenko AS, Niko Y, Hattori M.
    Biol Pharm Bull. 2023;46(12):1820-1825. doi: 10.1248/bpb.b23-00592.

  • Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains.
    Hiranyakorn M, Yagi-Utsumi M, Yanaka S, Ohtsuka N, Momiyama N, Satoh T, Kato K.
    Int J Mol Sci. 2023 Mar 23;24(7):6075. doi: 10.3390/ijms24076075.

  • VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells.
    Sakamoto M, Nagata Y, Furukawa A, Kusada T, Inamoto S, Senda T, Hirashima N, Suzuki R.
    Biochem Biophys Res Commun. 2024 Jan 8;691:149258. doi: 10.1016/j.bbrc.2023.149258. Epub 2023 Nov 23.

  • Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells.
    Shimizu Y, Tamiya-Koizumi K, Tsutsumi T, Kyogashima M, Kannagi R, Iwaki S, Aoyama M, Tokumura A.
    Lipids. 2023 Mar;58(2):93-103. doi: 10.1002/lipd.12366. Epub 2023 Jan 28.

  • IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells.
    Otsuka Y, Kondo T, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, Miyazawa K, Goto S, Aoyama M.
    J Pharmacol Sci. 2023 Jan;151(1):1-8. doi: 10.1016/j.jphs.2022.10.007. Epub 2022 Oct 21.

  • A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group.
    Ieda N, Nakamura A, Tomita N, Ohkubo K, Izumi R, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    RSC Adv. 2023 Sep 4;13(38):26375-26379. doi: 10.1039/d3ra03826b. eCollection 2023 Sep 4.

  • SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner.
    Nagasaka M, Inoue Y, Nagao Y, Miyajima C, Morishita D, Aoki H, Aoyama M, Imamura T, Hayashi H.
    Sci Rep. 2023 Dec 18;13(1):22877. doi: 10.1038/s41598-023-49961-x.

  • Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer.
    Sugimura N, Kubota E, Mori Y, Aoyama M, Tanaka M, Shimura T, Tanida S, Johnston RN, Kataoka H.
    Cancer Immunol Immunother. 2023 Nov;72(11):3593-3608. doi: 10.1007/s00262-023-03509-0. Epub 2023 Aug 1.

  • Molecular Design of FRET Probes Based on Domain Rearrangement of Protein Disulfide Isomerase for Monitoring Intracellular Redox Status.
    Yagi-Utsumi M, Miura H, Ganser C, Watanabe H, Hiranyakorn M, Satoh T, Uchihashi T, Kato K, Okazaki KI, Aoki K.
    Int J Mol Sci. 2023 Aug 16;24(16):12865. doi: 10.3390/ijms241612865.

  • Monocyte-Derived miRNA-1914-5p Attenuates IL-1β-Induced Monocyte Adhesion and Transmigration.
    Toriuchi K, Kihara T, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Shimono Y, Yamada Y, Aoyama M.
    Int J Mol Sci. 2023 Feb 1;24(3):2829. doi: 10.3390/ijms24032829.

  • Formation of two-dimensional diamond-like colloidal crystals using layer-by-layer electrostatic self-assembly.
    Fujita M, Toyotama A, Okuzono T, Niinomi H, Yamanaka J.
    Soft Matter. 2024 Jan 10. doi: 10.1039/d3sm01278f. Online ahead of print.

  • Optimizing adjuvant inhaled chemotherapy: Synergistic enhancement in paclitaxel cytotoxicity by flubendazole nanocrystals in a cycle model approach.
    Miyagi MYS, de Oliveira Faria R, de Souza GB, Lameu C, Tagami T, Ozeki T, Bezzon VDN, Yukuyama MN, Bou-Chacra NA, de Araujo GLB.
    Int J Pharm. 2023 Sep 25;644:123324. doi: 10.1016/j.ijpharm.2023.123324. Epub 2023 Aug 15.

  • Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients.
    Nakamura R, Arakawa N, Tanaka Y, Uchiyama N, Sekine A, Mashimo Y, Tsuji K, Kagawa T, Sato K, Watanabe M, Aiso M, Hiasa Y, Takei Y, Ohira H, Ayada M, Tsukagoshi E, Maekawa K, Tohkin M, Saito Y, Takikawa H.
    Hepatol Res. 2023 May;53(5):440-449. doi: 10.1111/hepr.13874. Epub 2023 Jan 14.

  • Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber.
    Liu Y, Nose I, Terasaka K, Fueki T, Makino T.
    J Nat Med. 2023 Sep;77(4):761-773. doi: 10.1007/s11418-023-01717-7. Epub 2023 Jun 13.

  • Hysteresis behavior in the unfolding/refolding processes of a protein trapped in metallo-cages.
    Nakama T, Rossen A, Ebihara R, Yagi-Utsumi M, Fujita D, Kato K, Sato S, Fujita M.
    Chem Sci. 2023 Feb 22;14(11):2910-2914. doi: 10.1039/d2sc05879k. eCollection 2023 Mar 15.

  • Design of Cell-Adhesive Shellac Derivatives and Endowment of Photoswitchable Cell-Adhesion Properties.
    Sunakawa Y, Kondo M, Yamamoto Y, Inomata T, Inoue Y, Mori D, Mizuno T.
    ACS Appl Bio Mater. 2023 Dec 18;6(12):5493-5501. doi: 10.1021/acsabm.3c00684. Epub 2023 Nov 17.

  • A Combinatorial Code for CPEB-Mediated c-myc Repression.
    Ogami K, Ogawa K, Sanpei S, Ichikawa F, Udagawa T, Hoshino SI.
    Cells. 2023 Oct 6;12(19):2410. doi: 10.3390/cells12192410.

  • Impact of body mass index on the severity of bexarotene-associated hypertriglyceridemia: A post hoc analysis of an open-labeled clinical study of combined bexarotene and phototherapy in Japanese patients with cutaneous T-cell lymphoma.
    Sanagawa A, Hayakawa T, Nishida E, Yamamoto A, Ikumi K, Mori Y, Hotta Y, Kimura K, Furukawa-Hibi Y, Morita A.
    J Dermatol. 2023 Jul;50(7):917-926. doi: 10.1111/1346-8138.16801. Epub 2023 Apr 11.

  • Epidemiology and predictors of hyponatremia in a contemporary cohort of patients with malignancy: a retrospective cohort study.
    Murashima M, Ambe K, Aoki Y, Kasugai T, Tomonari T, Ono M, Mizuno M, Tohkin M, Hamano T.
    Clin Kidney J. 2023 Aug 10;16(11):2072-2081. doi: 10.1093/ckj/sfad189. eCollection 2023 Nov.

  • Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors.
    Seetaha S, Kamonsutthipaijit N, Yagi-Utsumi M, Seako Y, Yamaguchi T, Hannongbua S, Kato K, Choowongkomon K.
    Protein J. 2023 Dec;42(6):741-752. doi: 10.1007/s10930-023-10156-y. Epub 2023 Sep 20.

  • The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells.
    Tozaki Y, Aoki H, Kato R, Toriuchi K, Arame S, Inoue Y, Hayashi H, Kubota E, Kataoka H, Aoyama M.
    Cancers (Basel). 2023 Jan 25;15(3):735. doi: 10.3390/cancers15030735.

  • N-linked glycosylation of flavivirus E protein contributes to viral particle formation.
    Ishida K, Yagi H, Kato Y, Morita E.
    PLoS Pathog. 2023 Oct 11;19(10):e1011681. doi: 10.1371/journal.ppat.1011681. eCollection 2023 Oct.

  • Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes.
    Hozuki S, Yoshioka H, Asano S, Nakamura M, Koh S, Shibata Y, Tamemoto Y, Sato H, Hisaka A.
    Clin Pharmacokinet. 2023 Jun;62(6):849-860. doi: 10.1007/s40262-023-01234-6. Epub 2023 Apr 19.

  • Design and Synthesis of Poly(2,2′-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations.
    Balachandran C, Hirose M, Tanaka T, Zhu JJ, Yokoi K, Hisamatsu Y, Yamada Y, Aoki S.
    Inorg Chem. 2023 Sep 11;62(36):14615-14631. doi: 10.1021/acs.inorgchem.3c01738. Epub 2023 Aug 29.

  • SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells.
    Miyaki R, Yamamura A, Kawade A, Fujiwara M, Kondo R, Suzuki Y, Yamamura H.
    Biochem Biophys Res Commun. 2022 Jun 4;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Epub 2022 Mar 25.

  • Inhibitory effect of Bofutsushosan (Fangfengtongshengsan) extract on the absorption of fructose in rats and mice.
    Takagi K, Sugihira T, Kitamura M, Kawai M, Mitsuguchi Y, Tsukamoto K, Nakanishi H, Makino T.
    J Nat Med. 2023 Jun;77(3):535-543. doi: 10.1007/s11418-023-01697-8. Epub 2023 Apr 11.

  • Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.
    Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC, Chen RP.
    Nat Commun. 2023 Sep 6;14(1):5464. doi: 10.1038/s41467-023-41156-2.

  • Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR.
    Yamaguchi Y, Yamaguchi T, Kato K.
    Adv Neurobiol. 2023;29:163-184. doi: 10.1007/978-3-031-12390-0_6.

  • In vitro-based prediction of human plasma concentrations of food-related compounds.
    Kitaguchi T, Ito M, Ohno K, Ota N, Kobayashi K, Sato H, Iwao T, Matsunaga T, Tanaka M, Hisaka A.
    ALTEX. 2023;40(4):595-605. doi: 10.14573/altex.2302131. Epub 2023 May 12.

  • High Density of N- and O-Glycosylation Shields and Defines the Structural Dynamics of the Intrinsically Disordered Ectodomain of Receptor-type Protein Tyrosine Phosphatase Alpha.
    Chien YC, Wang YS, Sridharan D, Kuo CW, Chien CT, Uchihashi T, Kato K, Angata T, Meng TC, Hsu SD, Khoo KH.
    JACS Au. 2023 Jun 13;3(7):1864-1875. doi: 10.1021/jacsau.3c00124. eCollection 2023 Jul 24.

  • Effect of cigarette smoke on mucosal vaccine response with activation of plasmacytoid dendritic cells: The outcomes of in vivo and in vitro experiments.
    Suzuki F, Maeyama JI, Kubota A, Nishimune A, Horiguchi S, Takii T, Urasaki Y, Shimada I, Iho S.
    Vaccine. 2023 Feb 17;41(8):1447-1456. doi: 10.1016/j.vaccine.2023.01.019. Epub 2023 Jan 24.

2022年度

  • A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes.
    Yamamoto C, Takemura A, Ishii S, Doi A, Saito I, Yamada H, Sakai Y, Matsunaga T, Ito K.
    J Toxicol Sci. 2022;47(1):13-18. doi: 10.2131/jts.47.13.

  • Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan.
    Umezawa F, Natsume M, Fukusada S, Nakajima K, Yamasaki F, Kawashima H, Kuo CW, Khoo KH, Shimura T, Yagi H, Kato K.
    Int J Mol Sci. 2022 Jun 15;23(12):6662. doi: 10.3390/ijms23126662.

  • An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9.
    Saito T, Yagi H, Kuo CW, Khoo KH, Kato K.
    Commun Biol. 2022 Jul 13;5(1):676. doi: 10.1038/s42003-022-03616-1.

  • Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation.
    Ieda N, Yoshikawa Y, Tomita N, Ohkubo K, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    Chem Commun (Camb). 2022 Jul 26;58(60):8420-8423. doi: 10.1039/d2cc03193k.

  • Three-Dimensional Printing of an Apigenin-Loaded Mucoadhesive Film for Tailored Therapy to Oral Leukoplakia and the Chemopreventive Effect on a Rat Model of Oral Carcinogenesis.
    Takashima H, Tagami T, Kato S, Pae H, Ozeki T, Shibuya Y.
    Pharmaceutics. 2022 Jul 28;14(8):1575. doi: 10.3390/pharmaceutics14081575.

  • Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail.
    Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino SI, Imai S, Shimada I, Osawa M.
    J Biol Chem. 2022 May;298(5):101844. doi: 10.1016/j.jbc.2022.101844. Epub 2022 Mar 18.

  • GALAXY ver3: updated web application for glycosylation profiling based on 3D HPLC map.
    Yagi H, Amagasa E, Shiota M, Yamada I, Aoki-Kinoshita KF, Kato K.
    Glycobiology. 2022 Jul 13;32(8):646-650. doi: 10.1093/glycob/cwac025.

  • The SYNGAP1 3’UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK.
    Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G.
    J Neurosci. 2022 Nov 23;42(47):8881-8896. doi: 10.1523/JNEUROSCI.0455-22.2022. Epub 2022 Oct 19.

  • Effect of Topiroxostat on Reducing Oxidative Stress in the Aorta of Streptozotocin-Induced Diabetic Rats
    Noda M, Kikuchi C, Tarui R, Nakamura T, Murase T, Hori E, Matsunaga T.
    Biol Pharm Bull. 2023 Feb 1;46(2):272-278. doi: 10.1248/bpb.b22-00694. Epub 2022 Dec 16.

  • Suspension culture of human induced pluripotent stem cell-derived intestinal organoids using natural polysaccharides.
    Ogawa I, Onozato D, Anno S, Hayashi H, Kanaki T, Iwao T, Matsunaga T.
    Biomaterials. 2022 Sep;288:121696. doi: 10.1016/j.biomaterials.2022.121696. Epub 2022 Aug 7.

  • Peripheral neuropathy in the pre-diabetic state of the type 2 diabetes mouse model (TSOD mice) involves TRPV1 expression in dorsal root ganglions.
    Shida K, Ohsawa M, Takahashi S, Ota H, Tamura T, Kusama N, Nakasone M, Yamazaki H, Sobue K.
    IBRO Neurosci Rep. 2022 Feb 8;12:163-169. doi: 10.1016/j.ibneur.2022.02.001. eCollection 2022 Jun.

  • Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion.
    Yanaka S, Nishiguchi S, Yogo R, Watanabe H, Shen J, Yagi H, Uchihashi T, Kato K.
    Int J Mol Sci. 2022 Feb 14;23(4):2090. doi: 10.3390/ijms23042090.

  • Upregulated ClC3 Channels/Transporters Elicit Swelling-Activated Cl- Currents and Induce Excessive Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension.
    Amano T, Yamamura A, Fujiwara M, Hirai S, Kondo R, Suzuki Y, Yamamura H.
    Biol Pharm Bull. 2022 Nov 1;45(11):1684-1691. doi: 10.1248/bpb.b22-00513. Epub 2022 Aug 20.

  • Clinical Usefulness of the “MN Criteria” – the Clostridioides difficile Infection Severity Scoring System – in the Japanese Setting.
    Asaoka M, Horita Y, Wachino C, Kondo S, Hotta Y, Kataoka T, Sanagawa A, Hayakawa T, Nakamura A, Kimura K.
    Intern Med. 2023 Jan 1;62(1):59-67. doi: 10.2169/internalmedicine.9540-22. Epub 2022 May 31.

  • Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.
    Mitani F, Lin J, Sakamoto T, Uehara R, Hikita T, Yoshida T, Setiawan A, Arai M, Oneyama C.
    Sci Rep. 2022 Apr 23;12(1):6674. doi: 10.1038/s41598-022-10692-0.

  • MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function.
    Hikita T, Uehara R, Itoh RE, Mitani F, Miyata M, Yoshida T, Yamaguchi R, Oneyama C.
    Cancer Sci. 2022 Apr;113(4):1264-1276. doi: 10.1111/cas.15288. Epub 2022 Feb 13.

  • SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells.
    Mitani F, Hayasaka R, Hirayama A, Oneyama C.
    Biol Pharm Bull. 2022;45(10):1572-1580. doi: 10.1248/bpb.b22-00560.

  • Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3.
    Miyake K, Yasujima T, Takahashi S, Yamashiro T, Yuasa H.
    J Biol Chem. 2022 Aug;298(8):102161. doi: 10.1016/j.jbc.2022.102161. Epub 2022 Jun 17.

  • Glutamine-free mammalian expression of recombinant glycoproteins with uniform isotope labeling: an application for NMR analysis of pharmaceutically relevant Fc glycoforms of human immunoglobulin G1.
    Yanaka S, Yagi H, Yogo R, Onitsuka M, Kato K.
    J Biomol NMR. 2022 Apr;76(1-2):17-22. doi: 10.1007/s10858-021-00387-5. Epub 2022 Jan 3.

  • 2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation.
    Uehara I, Kajita M, Tanimura A, Hida S, Onda M, Naito Z, Taki S, Tanaka N.
    Pharmacol Res Perspect. 2022 Apr;10(2):e00940. doi: 10.1002/prp2.940.

  • A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia.
    Miyagawa T, Tanaka S, Shimada M, Sakai N, Tanida K, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kanbayashi T, Imanishi A, Ikegami A, Kamei Y, Hida A, Wada Y, Miyamoto M, Takami M, Kondo H, Tamura Y, Taniyama Y, Omata N, Mizuno T, Moriya S, Furuya H, Kato M, Kato K, Ishigooka J, Tsuruta K, Chiba S, Yamada N, Okawa M, Hirata K, Kuroda K, Kume K, Uchimura N, Kitada M, Kodama T, Inoue Y, Nishino S, Mishima K, Tokunaga K, Honda M.
    NPJ Genom Med. 2022 Apr 12;7(1):29. doi: 10.1038/s41525-022-00298-w.

  • Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker.
    Ishiuchi K, Morinaga O, Yoshino T, Mitamura M, Hirasawa A, Maki Y, Tashita Y, Kondo T, Ogawa K, Lian F, Ogawa-Ochiai K, Minamizawa K, Namiki T, Mimura M, Watanabe K, Makino T.
    Front Pharmacol. 2022 Nov 24;13:1090327. doi: 10.3389/fphar.2022.1090327. eCollection 2022.

  • Overall structure of fully assembled cyanobacterial KaiABC circadian clock complex by an integrated experimental-computational approach.
    Yunoki Y, Matsumoto A, Morishima K, Martel A, Porcar L, Sato N, Yogo R, Tominaga T, Inoue R, Yagi-Utsumi M, Okuda A, Shimizu M, Urade R, Terauchi K, Kono H, Yagi H, Kato K, Sugiyama M.
    Commun Biol. 2022 Mar 10;5(1):184. doi: 10.1038/s42003-022-03143-z.

  • An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia.
    Ieda N, Sawada M, Oguchi R, Itoh M, Hirakata S, Saitoh D, Nakao A, Kawaguchi M, Sawamoto K, Yoshihara T, Mori Y, Nakagawa H.
    Angew Chem Int Ed Engl. 2023 May 8;62(20):e202217585. doi: 10.1002/anie.202217585. Epub 2023 Apr 12.

  • Time-series transcriptomic screening of factors contributing to the cross-tolerance to UV radiation and anhydrobiosis in tardigrades.
    Yoshida Y, Satoh T, Ota C, Tanaka S, Horikawa DD, Tomita M, Kato K, Arakawa K.
    BMC Genomics. 2022 May 28;23(1):405. doi: 10.1186/s12864-022-08642-1.

  • Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis.
    Kimura Y, Aoki H, Soyama T, Sakuragi A, Otsuka Y, Nomoto A, Yano S, Nishie H, Kataoka H, Aoyama M.
    Med Oncol. 2022 Apr 28;39(5):82. doi: 10.1007/s12032-022-01674-3.

  • Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
    Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C, Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T, Tanaka Y, Matsunaga T.
    Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

  • Drug-interaction between paclitaxel and goshajinkigan extract and its constituents.
    Nakayama A, Tsuchiya K, Xu L, Matsumoto T, Makino T.
    J Nat Med. 2022 Jan;76(1):59-67. doi: 10.1007/s11418-021-01552-8. Epub 2021 Jul 25.

  • PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy.
    Morita K, Wada M, Nakatani K, Matsumoto Y, Hayashi N, Yamahata I, Mitsunari K, Mukae N, Takahashi M, Izumi Y, Bamba T, Shirane M.
    iScience. 2022 Nov 16;25(12):105612. doi: 10.1016/j.isci.2022.105612. eCollection 2022 Dec 22.

  • Effect of Replicative Senescence on the Expression and Function of Transporters in Human Proximal Renal Tubular Epithelial Cells.
    Sanagawa A, Hotta Y, Sezaki R, Tomita N, Kataoka T, Furukawa-Hibi Y, Kimura K.
    Biol Pharm Bull. 2022;45(11):1636-1643. doi: 10.1248/bpb.b22-00322.

  • Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
    Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, Koga D, Takeishi S, Nakatsumi H, Hosen N, Robine S, Taketo MM, Sato T, Nakayama KI.
    Nat Commun. 2022 Mar 21;13(1):1500. doi: 10.1038/s41467-022-29165-z.

  • Biological functions of α2-adrenergic-like octopamine receptor in Drosophila melanogaster.
    Nakagawa H, Maehara S, Kume K, Ohta H, Tomita J.
    Genes Brain Behav. 2022 Jul;21(6):e12807. doi: 10.1111/gbb.12807. Epub 2022 Apr 12.

  • Historical Study for the Differences of Processing of Pinellia ternata Tuber Between China and Japan
    Liu Y, Ota M, Fueki T, Makino T.
    Front Pharmacol. 2022 Jun 20;13:892732. doi: 10.3389/fphar.2022.892732. eCollection 2022.

  • Key Residue for Aggregation of Amyloid-β Peptides.
    Itoh SG, Yagi-Utsumi M, Kato K, Okumura H.
    ACS Chem Neurosci. 2022 Nov 16;13(22):3139-3151. doi: 10.1021/acschemneuro.2c00358. Epub 2022 Oct 27.

  • LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.
    Kawaguchi Y, Matsubayashi J, Kawakami Y, Nishida R, Kurihara Y, Takei K.
    Mol Med. 2022 Dec 12;28(1):154. doi: 10.1186/s10020-022-00581-7.

  • Editorial: Regulatory Mechanisms of Ca2+ Activated Ion Channels and Their Impact on Physiological/Pathophysiological Function.
    Suzuki Y, Ohya S, Giles WR.
    Front Physiol. 2022 Apr 4;13:876327. doi: 10.3389/fphys.2022.876327. eCollection 2022.

  • A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
    Suzuki Y, Ozawa T, Kurata T, Nakajima N, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
    Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2117435119. doi: 10.1073/pnas.2117435119. Epub 2022 Apr 11.

  • Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells.
    Kondo K, Harada Y, Nakano M, Suzuki T, Fukushige T, Hanzawa K, Yagi H, Takagi K, Mizuno K, Miyamoto Y, Taniguchi N, Kato K, Kanekura T, Dohmae N, Machida K, Maruyama I, Inoue H.
    J Biol Chem. 2022 Jun;298(6):101950. doi: 10.1016/j.jbc.2022.101950. Epub 2022 Apr 18.

  • Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats.
    Kataoka T, Hidaka J, Suzuki J, Mori T, Nakamura D, Hotta Y, Sanagawa A, Maeda Y, Furukawa-Hibi Y, Kimura K.
    Sex Med. 2022 Apr;10(2):100500. doi: 10.1016/j.esxm.2022.100500. Epub 2022 Mar 5.

  • Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.
    Ota M, Maki Y, Xu LY, Makino T.
    J Ethnopharmacol. 2022 Nov 15;298:115625. doi: 10.1016/j.jep.2022.115625. Epub 2022 Aug 13.

  • Heteroepitaxial fabrication of binary colloidal crystals by a balance of interparticle interaction and lattice spacing.
    Nozawa J, Uda S, Toyotama A, Yamanaka J, Niinomi H, Okada J.
    J Colloid Interface Sci. 2022 Feb 15;608(Pt 1):873-881. doi: 10.1016/j.jcis.2021.10.041. Epub 2021 Oct 13.

  • Interneurons of fan-shaped body promote arousal in Drosophila.
    Kato YS, Tomita J, Kume K.
    PLoS One. 2022 Nov 21;17(11):e0277918. doi: 10.1371/journal.pone.0277918. eCollection 2022.

  • Surface Plasmon Resonance of Two-Dimensional Gold Colloidal Crystals Formed on Gold Plates.
    Aoyama Y, Toyotama A, Okuzono T, Hirashima N, Imai H, Uchida F, Takiguchi Y, Yamanaka J.
    Chem Pharm Bull (Tokyo). 2022;70(2):130-137. doi: 10.1248/cpb.c21-00873.

  • Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines.
    Minami M, Konishi T, Takase H, Makino T.
    J Nat Med. 2022 Jan;76(1):244-253. doi: 10.1007/s11418-021-01585-z. Epub 2021 Nov 18.

  • Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer.
    Tagami T, Goto E, Kida R, Hirose K, Noda T, Ozeki T.
    Int J Pharm. 2022 Apr 5;617:121448. doi: 10.1016/j.ijpharm.2022.121448. Epub 2022 Jan 20.

  • Identification of responsible amino acid residues in staphylococcal superantigen-like 12 for the activation of mast cells.
    Kim G, Itoh S, Ito Y, Ohya S, Hida S.
    Genes Cells. 2022 Sep;27(9):559-567. doi: 10.1111/gtc.12973. Epub 2022 Jul 19.

  • Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells.
    Kondo D, Suzuki R, Matsumura A, Meguri H, Tanaka M, Itakura M, Hirashima N.
    Eur J Immunol. 2023 Dec;53(12):e2250360. doi: 10.1002/eji.202250360. Epub 2023 Oct 2.

  • The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa.
    Yamaguchi Y, Wakaizumi N, Irisa M, Maruno T, Shimada M, Shintani K, Nishiumi H, Yogo R, Yanaka S, Higo D, Torisu T, Kato K, Uchiyama S.
    MAbs. 2022 Jan-Dec;14(1):2038531. doi: 10.1080/19420862.2022.2038531.

  • Preparation, Characterization and In Vitro Evaluation of Eudragit S100-Coated Bile Salt-Containing Liposomes for Oral Colonic Delivery of Budesonide.
    Alghurabi H, Tagami T, Ogawa K, Ozeki T.
    Polymers (Basel). 2022 Jun 30;14(13):2693. doi: 10.3390/polym14132693.

  • FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
    Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H, Shimada M.
    Mol Oncol. 2022 Feb;16(4):940-956. doi: 10.1002/1878-0261.13030. Epub 2021 Jun 19.

  • The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
    Nagasaka M, Inoue Y, Yoshida M, Miyajima C, Morishita D, Tokugawa M, Nakamoto H, Sugano M, Ohoka N, Hayashi H.
    FEBS Lett. 2022 Feb;596(4):465-478. doi: 10.1002/1873-3468.14296. Epub 2022 Feb 11.

  • Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption.
    Yoshitomo A, Asano S, Hozuki S, Tamemoto Y, Shibata Y, Hashimoto N, Takahashi K, Sasaki Y, Ozawa N, Kageyama M, Iijima T, Kazuki Y, Sato H, Hisaka A.
    Drug Metab Dispos. 2023 Mar;51(3):318-328. doi: 10.1124/dmd.122.000907. Epub 2022 Dec 7.

  • Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia.
    Kondo T, Aoki H, Otsuka Y, Kawaguchi Y, Waguri-Nagaya Y, Aoyama M.
    J Pharmacol Sci. 2022 Jul;149(3):93-99. doi: 10.1016/j.jphs.2022.03.007. Epub 2022 Apr 16.

  • Protrudin regulates FAK activation, endothelial cell migration and angiogenesis.
    Arora A, Kivelä AM, Wang L, Minkeviciene R, Taskinen JH, Zhang B, Koponen A, Sun J, Shirane M, Zhou Y, Hotulainen P, Raiborg C, Olkkonen VM.
    Cell Mol Life Sci. 2022 Apr 4;79(4):220. doi: 10.1007/s00018-022-04251-z.

  • Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
    Kawade A, Yamamura A, Kondo R, Suzuki Y, Yamamura H.
    J Pharmacol Sci. 2023 Feb;151(2):119-127. doi: 10.1016/j.jphs.2022.12.007. Epub 2022 Dec 23.

  • Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model.
    Tomita N, Hotta Y, Naiki-Ito A, Sanagawa A, Kataoka T, Furukawa-Hibi Y, Takahashi S, Kimura K.
    J Pharmacol Sci. 2022 Jun;149(2):53-59. doi: 10.1016/j.jphs.2022.03.003. Epub 2022 Mar 25.

  • Characterization of Triterpene Saponin Glycyrrhizin Transport by Glycyrrhiza glabra.
    Kato K, Horiba A, Hayashi H, Mizukami H, Terasaka K.
    Plants (Basel). 2022 May 5;11(9):1250. doi: 10.3390/plants11091250.

  • Effect of High Testosterone Levels on Endothelial Function in Aorta and Erectile Function in Rats.
    Kataoka T, Fukamoto A, Hotta Y, Sanagawa A, Maeda Y, Furukawa-Hibi Y, Kimura K.
    Sex Med. 2022 Oct;10(5):100550. doi: 10.1016/j.esxm.2022.100550. Epub 2022 Aug 5.

  • The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes.
    Joyo Y, Kawaguchi Y, Yonezu H, Senda H, Yasuma S, Shiraga H, Nozaki M, Aoyama M, Asai K, Murakami H, Waguri-Nagaya Y.
    Immunol Res. 2022 Apr;70(2):208-215. doi: 10.1007/s12026-022-09261-4. Epub 2022 Jan 10.

  • Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
    Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H.
    Eur J Neurol. 2022 May;29(5):1410-1416. doi: 10.1111/ene.15254. Epub 2022 Feb 6.

  • Effect of steam-processing of the Panax ginseng root on its inducible activity on granulocyte-colony stimulating factor secretion in intestinal epithelial cells in vitro.
    Ding K, Tabuchi Y, Makino T.
    J Ethnopharmacol. 2022 Apr 6;287:114927. doi: 10.1016/j.jep.2021.114927. Epub 2021 Dec 23.

2021年度

  • Tokugawa M, Inoue Y, Ishiuchi K, Kujirai C, Matsuno M, Ri M, Itoh Y, Miyajima C, Morishita D, Ohoka N, Iida S, Mizukami H, Makino T, Hayashi H.
    Periplocin and cardiac glycosides suppress the unfolded protein response.
    Sci. Rep., 11, 9528（2021）

  • Shimeng Qiu, Yaling Li, Shinji Mima, Yuki Imakura, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
    An efficient method for the differentiation of human iPSC-derived endoderm toward enterocytes and hepatocytes.
    Cells, 10, 4, 812 (2021)

  • Sawahata, M., Asano, H., Nagai, T., Ito, N., Kohno, T., Nabeshima, T., Hattori, M., and Yamada, K. (2021)
    Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice.
    Pharmacol. Res. 173, 105832 （2021）

  • Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M.
    Establishment of a threshold of toxicological concern concept for skin sensitization by in vitro/in silico approaches.
    Journal of Japanese Cosmetic Science Society. 45(4):331-335(2021)

  • Ambe K, Suzuki M, Ashikaga T, Tohkin M.
    Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning Catboost.
    Regul Toxicol Pharmacol. 125:105019. (2021）

  • Ri M, Iida S, Maruyama D, Sakabe A, Kamei R, Nakashima T, Tohkin M, Osaga S, Tobinai K, Fukuhara N, Miyazaki K, Tsukamoto N, Tsujimura H, Yoshimitsu M, Miyamoto K, Tsukasaki K, Nagai H.
    HLA genotyping in Japanese patients with multiple myeloma receiving bortezomib: An exploratory biomarker study of JCOG1105 (JCOG1105A1).
    Cancer Sci. Dec;112(12):5011-5019 （2021）

  • Nagae, M., Suzuki, K., Yasui, N., Nogi, T., Kohno, T., Hattori, M., and Takagi, L.
    Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization.
    J. Biochem. 169, 555-564 (2021)

  • Tsuneura, Y., Sawahata, M., Itoh, N., Miyajima, R., Mori, D., Kohno, T., Hattori, M., Sobue, A., Nagai, T., Mizoguchi, H., Nabeshoima, T., Ozaki, N., and Yamada, K.
    Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia.
    Neurochem. Int. 144, 104954 (2021)

  • Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Takashi, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka, Tamihide Matsunaga.
    Simultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells
    Drug Metab Dispos., in press (2021)

  • Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H.
    Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes
    Biochem Biophys Res Commun., 537:29-35 (2021)

  • Kawade A, Yamamura A, Fujiwara M, Kobayashi S, Mori S, Horii C, Hiraku A, Suzumura S, Tsukamoto K, Ohara N, Kondo R, Suzuki Y, Yamamura H.
    Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats
    J Pharmacol Sci., 147:81-85 (2021)

  • Suzuki R., Inoh Y., Yokawa S., Furuno T., Hirashima N.
    Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells.
    Biochem. Biophys. Res. Commun. 534, 714-719 (2021)

  • Keiichi Taniguchi, Daisuke Hayashi, Naomi Yasuda, Mao Nakayama, Kaori Yazawa, Shouta Ogawa, Yuji Miyatake, Saki Suda , Haruka Tomita, Miki Tokuda, Saotomo Itoh, Jun-Ichi Maeyama, Naoya Ohara, Saburo Yamamoto, Shigeaki Hida, Kikuo Onozaki, Takemasa Takii
    Comparative Study of the Susceptibility to Oxidative Stress between Two Types of Mycobacterium bovis BCG Tokyo 172.
    mSphere. 6(2):e00111-00121 （2021）

  • Chigusa Kikuchi, Akiko Sakasai-Sakai, Risa Okimura, Hinako Tanaka, Takanobu Takata, Masayoshi Takeuchi, Tamihide Matsunaga,
    Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells.
    Biol Pharm Bull. 44, 10, 1399-1402 (2021)

  • M. Ohsawa, Y. Uezono, A. Inui
    Editorial: Ageing-Related Symptoms, Kampo Medicine, and Treatment.
    Front. Nutr.8 e749320 (2021)

  • M. Ohsawa, T. Makino, Y. Takimoto, A. Inui
    Application of Kampo medicines for the palliation of cancer cachexia.,
    Neuropeptides 90 e102188 （2021）

  • Y. Takeuchi, A.J. Nagy, L. Barcsai, Q. Li, M. Ohsawa, K. Mizuseki, A. Berényi
    The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.,
    Front. Neural Circuits 15 e701080 (2021)

  • Y. Takeuchi, M. Harangozó, L. Pedraza, T. Földi, G. Kozák, Q. Li, A. Berényi
    Closed-loop stimulation of the medial septum terminates epileptic seizures.,
    Brain 144 885-908 (2021)

  • K.C. Robinson, L. V Kemény, G.L. Fell, A.L. Hermann, J. Allouche, W. Ding, A. Yekkirala, J.J. Hsiao, M.Y. Su, N. Theodosakis, G. Kozak, Y. Takeuchi, S. Shen, A. Berenyi, J. Mao, C.J. Woolf, D.E. Fisher
    Reduced MC4R signaling alters nociceptive thresholds associated with red hair.,
    Sci. Adv. 7 abd1310 (2021)

  • T. Gao, J. Li, Y. Watanabe, C. Hung, A. Yamanaka, K. Horie, M. Yanagisawa, M. Ohsawa, K. Kume
    GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm
    Clocks & Sleep 3 581-597 (2021)

  • T. Muto, M.I. Yoshizawa, C. Kim, K. Kume,
    Sleep-improving effects of a novel motion mattress
    Sleep Biol. Rhythms 19 247-253 (2021)

  • A. Ambati, R. Hillary, S. Leu-Semenescu, H.M. Ollila, L. Lin, E.H. During, N. Farber, T.J. Rico, J. Faraco, E. Leary, A.N. Goldstein-Piekarski, Y.-S. Huang, F. Han, Y. Sivan, M. Lecendreux, P. Dodet, M. Honda, N. Gadoth, S. Nevsimalova, F. Pizza, T. Kanbayashi, R. Peraita-Adrados, G.D. Leschziner, R. Hasan, F. Canellas, K. Kume, M. Daniilidou, P. Bourgin, D. Rye, J.L. Vicario, B. Hogl, S.C. Hong, G. Plazzi, G. Mayer, A.M. Landtblom, Y. Dauvilliers, I. Arnulf, E.J.-M. Mignot
    Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci,,
    Proc. Natl. Acad. Sci. e2005753118 (2021)

  • N. Kon, H.-T. Wang, Y.S. Kato, K. Uemoto, N. Kawamoto, K. Kawasaki, R. Enoki, G. Kurosawa, T. Nakane, Y. Sugiyama, H. Tagashira, M. Endo, H. Iwasaki, T. Iwamoto, K. Kume, Y. Fukada
    Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms.,
    Sci. Adv. 7 eabe8132 (2021)

  • Sai, K., Nakatani, E., Iwama, Y., Hiraoka, S., Tohkin, M., Uyama, Y., Saito, Y.
    Efficacy comparison for a schizophrenia and a dysuria drug among East Asian populations: A retrospective analysis using multi-regional clinical trial data
    Therapeutic Innovation & Regulatory Science 55:523-538. (2021）

  • Asano K., Aoi Y., Kamada S., Uyama Y., Tohkin M.
    Points to consider for implementation of the ICH
    E17 guideline: learning from past multi-regional clinical trials (MRCTs) in Japan. Clin Pharmacol Ther. 109:1555-1563. (2021）

  • Yamazoe Y, Tohkin M.
    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
    Drug Metab Pharmacokinet. 38:100357. (2021）

  • Toshie Kihara, Kohki Toriuchi, Hiromasa Aoki, Hiroki Kakita, Yasumasa Yamada, Mineyoshi Aoyama
    Interleukin-1β enhances cell adhesion in human endothelial cells via microRNA-1914-5p suppression
    Biochemistry and Biophysics Reports　27:101046 (2021）

  • Takao Kondo, Yuto Otsuka, Hiromasa Aoki, Yoh Goto, Yohei Kawaguchi, Yuko Waguri-Nagaya, Ken Miyazawa, Shigemi Goto, Mineyoshi Aoyama
    The Inducible Nitric Oxide Synthase Pathway Promotes Osteoclastogenesis under Hypoxic Culture Conditions
    The American Journal of Pathology 191:2072-2079 (2021）

  • Ken Mizuguchi, Hiromasa Aoki, Mineyoshi Aoyama, Yohei Kawaguchi, Yuko Waguri-Nagaya, Nobuyuki Ohte, Kiyofumi Asai
    Three-dimensional spheroid culture induces apical-basal polarity and the original characteristics of immortalized human renal proximal tubule epithelial cells
    Experimental Cell Research 404:112630 (2021）

  • Satoru Takeshita, Hiroki Kakita, Kohki Toriuchi, Hiromasa Aoki, Hiroko Ueda, Akihiko Wakatsuki, Yasumasa Yamada, Mineyoshi Aoyama
    Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small-for-gestational-age rats
    British journal of haematology 192(4):e105-e108 (2021）

  • Tatsuki Soyama, Akira Sakuragi, Daisuke Oishi, Yuka Kimura, Hiromasa Aoki, Akihiro Nomoto, Shigenobu Yano, Hirotada Nishie, Hiromi Kataoka, Mineyoshi Aoyama
    Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages
    Translational oncology 14:101005 (2021）

  • Takao Namiki, Shin Takayama, Ryutaro Arita, Tadashi Ishii, Mosaburo Kainuma, Toshiaki Makino, Masaru Mimura, Tetsuhiro Yoshino, Tatsuya Nogami, Makoto Arai, Juichi Sato, Koichiro Tanaka, Hajime Nakae, Hidetoshi Igari, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Masahiko Nezu, Takashi Ito
    A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)
    Trials. 22: 23 (2021）

  • Kan’ichiro Ishiuchi, Osamu Morinaga, Tetsuhiro Yoshino, Miaki Mitamura, Asuka Hirasawa, Yasuhito Maki, Yuuna Tashita, Tsubasa Kondo, Kakuyou Ogawa, Fangyi Lian, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Takao Namiki, Masaru Mimura, Kenji Watanabe, Toshiaki Makino
    Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker
    Frontiers Pharmacol. 12, 688508, 202 (2021）

  • Misato Ota, Hao Ni, Yasuhito Maki, Daiki Kato, Shohei Moriguchi, Shuto Nakayama, Yuki Oiwa, Kan’ichiro Ishiuchi, Toshiaki Makino
    Binding activity of Valeriana fauriei root extract on GABAA receptor flunitrazepam sites and distribution of its active ingredients in the brain of mice – a comparison with that of V. officinalis root
    J. Ethnopharmacol. 278, 114262 (2021）

  • Manhui Zhang, Kouhei Kobayashi, Haruki Atsumi, Yuma Katada, Yusuke Nakane, Junfeng Chen, Ryo Nagano, Naoya Kadofusa, Taeko Nishiwaki-Ohkawa, Naohiro Kon, Tsuyoshi Hirota, Ayato Sato, Toshiaki Makino, Takashi Yoshimura
    Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine
    Sci. Rep. 11, 21038 (2021）

  • Secil Sarikaya Aydin, Vahap Murat Kutluay, Toshiaki Makino, Makoto Inoue, Ummuhan Sebnem Harput, Iclal Saracoglu
    Isolation of potential liver x receptor alpha agonist and antioxidant compounds from Hypericum microcalycinum Boiss. & Heldr.
    J. Facul. Pharma. Istanbul Univ. 51, 98–105 (2021）

  • Shin Takayama, Akiko Kikuchi, Toshiaki Makino, Mosaburo Kainuma, Takao Namiki, Takashi Ito
    Basic pharmacological mechanisms and clinical evidence of the efficacy of Hochuekkito against infectious diseases and its potential for use against COVID-19
    Tradit. Kampo 8: 3–21 (2021）

  • Tetsuhiro Yoshino, Saori Shimada, Masato Homma, Toshiaki Makino, Masaru Mimura, Kenji Watanabe
    linical risk factors of licorice-induced pseudoaldosteronism based on the concentrations of glycyrrhizin-metabolites; a narrative review
    Frontiers Nutr. 8: 719197 (2021）

  • 笛木司、田中耕一郎、千葉浩輝、小原陣内、柴山周乃、並木隆雄、別府正志、牧野利明
    古典に記載された方剤を煎じる際に指定されている水量の意味－通脈四逆加猪胆汁湯と茯苓四逆湯のアコニチン型アルカロイド濃度に着目して－
    日本東洋医学雑誌、72(2): 107–118 (2021）

  • 関根麻理子、牧野利明、田中耕一郎、嶋田沙織、四日順子、古屋英治、地野充時、田原英一
    医療安全委員会報告〜漢方製剤に関する医療機関からの医療事故情報及びヒヤリ・ハット事例
    日本東洋医学雑誌、72(2): 182–207 (2021）

  • 牧野利明、安井廣迪、並木隆雄
    欧米の薬局方に収載された日本の医療用漢方製剤の原料生薬について – 東アジア各国の薬局方での名称と基原の比較
    日本東洋医学雑誌、72(4): 402–414 (2021）

  • Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H.
    Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes.
    Biochem Biophys Res Commun. 537:29-35 (2021)

  • Hashimoto D, Hirashima T, Yamamura H, Kataoka T, Fujimoto K, Hyuga T, Yoshiki A, Kimura K, Kuroki S, Tachibana M, Suzuki K, Yamamoto N, Morioka S, Sasaki T, Yamada G.
    Dynamic erectile responses of a novel penile organ model utilizing TPEM.
    Biol Reprod. 104(4):875-886 (2021)

  • Suzuki T, Suzuki Y, Asai K, Imaizumi Y, Yamamura H.
    Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl- channels.
    J Pharmacol Sci. 146:65-69 (2021)

  • Kataoka T, Mori T, Suzuki J, Kawaki Y, Kito Y, Hotta Y, Kawade Y, Maeda Y, Kimura K.
    Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction.
    J Sex Med. 18,1337-1345 (2021)

  • Ota Y, Kubota Y, Hotta Y, Matsumoto M, Matsuyama N, Kato T, Hamakawa T, Kataoka T, Kimura K, Sawamoto K, Yasui T.
    Change in the Central Control of the Bladder Function of Rats with Focal Cerebral Infarction induced by Photochemically-Induced Thrombosis.
    PLoS One. 16:e0255200 (2021)

  • Mori T, Hotta Y, Nakamura D, Yahagi R, Kataoka T, Kimura K.
    Enhancement of the RhoA/Rho Kinase Pathway is Associated with Stress-Related Eerectile Dysfunction in a Restraint Water-Immersion Stress Model.
    Physiol Rep. 9:e15064. (2021)

  • Sanagawa A, Hotta Y, Mori N, Tomita N, Kataoka T, Tohkin M, Kimura K.
    BRAF/MEK inhibitor-associated Nephrotoxicity in a Real-World Setting and Human Kidney Cells.
    Anticancer Drugs. 32:1076-1083 (2021)

  • Maeda K, Hotta Y, Kawata R, Kataoka T, Kimura K.
    Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-Injury Model.
    J Pharmacol Sci. 146:116-119 (2021)

  • Maeda K, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K.
    Control of Rat Bladder Neck Relaxation with NORD-1, a Red Light–Reactive Nitric Oxide Releaser: In Vitro Study.
    J Pharmacol Sci. 146:226-232 (2021)

  • Kataoka K, Hotta Y, Yamamoto Y, Fukamoto A, Takeuchi M, Maeda Y, Kimura K.
    Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats.
    Sex Med. 9:100348 (2021)

  • Kawata R, Hotta Y, Maeda K, Kataoka T, Kimura K.
    Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats.
    Nutrients. 13:539 (2021)

  • Maeda K, Hotta Y, Shibayama M, Kawata R, Kataoka T, Matsumoto S, Yamamoto T, Kimura K.
    Impairment of Accessory Nerves around Major Pelvic Ganglion leading to Overflow Urinary Incontinence in Rats.
    Neurourol Urodyn. 40:624-631 (2021)

  • Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohono E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M.
    Filtrated Adipose Tissue‑Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice.
    Dig Dis Sci. 66:1034-1044 (2021)

  • Siriluk Ratanabunyong, Niran Aeksiri, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kiattawee Choowongkomol, and Supa Hannongbua,
    Characterization of new DNA aptamers for anti-HIV-1 reverse transcriptase
    ChemBioChem 22, 915-923 (2021)

  • Saeko Yanaka, Yoshiki Yamaguchi, Takeshi Takizawa, Yohei Miyanoiri, Rina Yogo, Ichio Shimada, and Koichi Kato
    NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein
    Biomol. NMR Assign. 15, 187-192 (2021)

  • Siriluk Ratanabunyong, MahoYagi-Utsumi, SaekoYanaka, Koichi Kato, Kiattawee Choowongkomon, and Supa Hannongbua
    Investigation of RT1t49 aptamer binding to human immunodeficiency virus 1 reverse transcriptase
    J. Curr. Sci. and Technol. 11, 51-59 (2021)

  • Aya Okuda, Rintaro Inoue, Ken Morishima, Tomohide Saio, Yasuhiro Yunoki, Maho Yagi-Utsumi, Hirokazu Yagi, Masahiro Shimizu, Nobuhiro Sato, Reiko Urade, Koichi Kato, and Masaaki Sugiyama
    Deuteration aiming for neutron scattering
    Biophys. Physicobiol. 18, 16-27 (2021)

  • Maho Yagi-Utsumi, Tomohiro Tanaka, Yoko Otsubo, Akira Yamashita, Shinji Yoshimura, Motohiro Nishida, and Koichi Kato
    Cold atmospheric plasma modification of amyloid β
    Int. J. Mol. Sci. 22, 3116 (2021)

  • Chihong Song, Tadashi Satoh, Taichiro Sekiguchi, Koichi Kato and Kazuyoshi Murata
    Structural fluctuations of the human proteasome α7 homo-tetradecamer double ring imply the proteasomal α-ring assembly mechanism
    Int. J. Mol. Sci. 22, 4519 (2021)

  • Tokio Watanabe, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, and Koichi Kato
    Comprehensive characterization of oligosaccharide conformational ensembles with conformer classification by free-energy landscape via reproductive kernel Hilbert space
    Phys. Chem. Chem. Phys. 23, 9753-9760 (2021)

  • Ryo Ohtani, Yuka Anegawa, Hikaru Watanabe, Yutaro Tajima, Masanao Kinoshita, Nobuaki Matsumori, Kenichi Kawano, Saeko Yanaka, Koichi Kato, Masaaki Nakamura, Masaaki Ohba, and Shinya Hayami
    Metal complex lipids for fluid-fluid phase separation in co-assembled phospholipid membranes
    Angew. Chem. Int. Ed. 70, 13603-13608 (2021)

  • Kazuhisa Miyazawa, Satoru G. Itoh, Hiroki Watanabe, Takayuki Uchihashi, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kazuharu Arakawa, and Hisashi Okumura
    Tardigrade secretory-abundant heat-soluble protein has a flexible β‑barrel structure in solution and keeps this structure in dehydration
    J. Phys. Chem. B. 125, 9145-9154 (2021)

  • Nobuhiro Sato, Rina Yogo, Saeko Yanaka, Anne Martel, Lionel Porcar, Ken Morishima, Rintaro Inoue, Taiki Tominaga, Takao Arimori, Junichi Takagi, Masaaki Sugiyama, and Koichi Kato
    A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems
    J. Biochem. 169, 701-708 (2021).

  • Fumiya Yamasakia, Fumiko Umezawa, Tomohiro Sensui, Masashi Anzo, Hirohito Abo, Chu-Wei Kuo, Kay-Hooi Khoo, Koichi Kato, Hirokazu Yagi, and Hiroto Kawashima
    Establishment of a novel monoclonal antibody against truncated glycoforms of α-dystroglycan lacking matriglycans
    Biochem. Biophys. Res. Commun. 579, 8-14

  • Maho Yagi-Utsumi, Kazuhiro Aoki, Hiroki Watanabe, Chihong Song, Seiji Nishimura, Tadashi Satoh, Saeko Yanaka, Christian Ganser, Sae Tanaka, Vincent Schnapka, Ean Wai Goh, Yuji Furutani, Kazuyoshi Murata, Takayuki Uchihashi, Kazuharu Arakawa and Koichi Kato
    Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
    Sci. Rep. 11, Article number: 21328 (2021).

  • Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, and Kazutoshi Mori
    Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD
    eLife 10, e70357 (2021)

  • Yumi Murai, Maho Yagi-Utsumi, Masayuki Fujiwara, Sae Tanaka, Masaru Tomita, Koichi Kato and Kazuharu Arakawa
    Multiomics study of a heterotardigrade, Echinisicus testudo, suggests the possibility of convergent evolution of abundant heat- soluble proteins in Tardigrada
    BMC Genomics 22, 813 (2021).

  • Daishi Fujita, Ryoto Suzuki, Yuya Fujii, Mayu Yamada, Takahiro Nakama, Akimasa Matsugami, Fumiaki Hayashi, Jing-Ke Weng, MahoYagi-Utsumi, and MakotoFujita
    Protein stabilization and refolding in a gigantic self-assembled cage
    Chem 7, 2672-2683 (2021)

  • Hiroki Kitagawa, Masaki Kikuchi, Shin Sato, Hisami Watanabe, Naoki Umezawa, Maiko Kato, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi, “Structure-based identification of potent lysine-specific demethylase 1 inhibitor peptides and temporary cyclization to enhance proteolytic stability and cell growth-inhibitory activity”,
    J. Med. Chem., 64, 7, 3707-3719 (2021)

  • Yosuke Hisamatsu, Koki Otani, Hiroshi Takase, Naoki Umezawa, Tsunehiko Higuchi, “Fluorescence response and self-assembly of a tweezer-type synthetic receptor triggered by complexation with heme and its catabolites”,
    Chem. Eur. J., 27, 21, 6489-6499 (2021)

  • Tomoki Kitagawa, Takashi Nishio, Yuko Yoshikawa, Naoki Umezawa, Tsunehiko Higuchi, Chwen-Yang Shew, Takahiro Kenmotsu, Kenichi Yoshikawa, “Effects of structural isomers of spermine on the higher-order structure of DNA and gene expression”,
    Int. J. Mol. Sci., 22, 5, 2355-2369 (2021)

  • Kazuya Matsuo, Sampreeth Thayyil, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, and Nobuyuki Tamaoki
    A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole
    Chem. Commun., 57(93), 12500-12503 (2021)

  • Mitsuyasu Kawaguchi, Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami, and Hidehiko Nakagawa
    Synthesis of fluorescence probes targeting tumor-suppressor protein FHIT and identification of apoptosis-inducing FHIT inhibitors
    J. Med. Chem., 64, 9567-9576 (2021)

  • Kasin Yadunandam Anandam, Padmanabhan Srinivasan, Tomoya Yasujima, Saleh Al-Juburi, Hamid M. Said
    Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).
    Am. J. Physiol. Gastrointest. Liver Physiol., 320, G108-G116 (2021)

  • Mitsuyasu Kawaguchi , Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami, Hidehiko Nakagawa
    Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors
    J Med Chem., 64, 9567-9576 (2021)

  • Sato, T., Cheng, C.-L., Park, H.-W., Kao Yang, Y.-H., Min-Suk Yang, M.-S., Fujita, M., Kumagai, Y., Tohkin, M., Saito, Y., Sai, K.
    Real World Evidence of Population Differences in Allopurinol- related Severe Cutaneous Adverse Reactions in East Asians: A Population-based Cohort Study
    Clin Trasnla Sci., 14(3): 1002 – 1014 (2021)

  • Ambe K, Suzuki M, Ashikaga T, Tohkin M.
    Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost
    Regul Toxicol Pharmacol., 105019 (2021)

  • Sanagawa A, Hotta Y, Mori N, Tomita N, Kataoka T, Tohkin M, Kimura K.
    BRAF/MEK inhibitor-associated nephrotoxicity in a real-world setting and human kidney cells
    Anticancer Drugs., 1;32(10):1076-1083 (2021)

  • Yamazoe Y, Tohkin M.
    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
    Drug Metab Pharmacokinet., 38:100357 (2021)

  • Kasin Yadunandam Anandam, Padmanabhan Srinivasan, Tomoya Yasujima, Saleh Al-Juburi, Hamid M.
    Said Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).
    Am. J. Physiol. Gastrointest. Liver Physiol., 320, G108-G116 (2021)

  • Nagae, M., Suzuki, K., Yasui, N., Nogi, T., Kohno, T., Hattori, M., and Takagi, L.
    Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization.
    J. Biochem., 169, 555-564 (2021)

  • Tsuneura, Y., Sawahata, M., Itoh, N., Miyajima, R., Mori, D., Kohno, T., Hattori, M.,
    Sobue, A., Nagai, T., Mizoguchi, H., Nabeshoima, T., Ozaki, N., and Yamada, K.
    Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured
    cortical neurons with RELN deletion identified in schizophrenia.
    Neurochem. Int., 144, 104954 (2021)

  • Sawahata, M., Asano, H., Nagai, T., Ito, N., Kohno, T., Nabeshima, T., Hattori, M., and
    Yamada, K.
    Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory
    impairment in mice.
    Pharmacolo. Res. 173, 105832. (2021)

2020年度

  • Qiu S, Kabeya T, Ogawa I, Anno S, Hayashi H, Kanaki T, Hashita T, Iwao T, Matsunaga T.
    Gellan gum promotes the differentiation of enterocytes from human induced pluripotent stem cells.
    Pharmaceutics., 12, 951 (2020)

  • Kabeya T, Mima S, Imakura Y, Miyashita T, Ogura I, Yamada T, Yasujima T, Yuasa H, Iwao T, Matsunaga T.
    Pharmacokinetic functions of human induced pluripotent stem cell-derived small intestinal epithelial cells.
    Drug Metab Pharmacokinet., 35, 374–382 (2020)

  • Onozato D, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, Matsunaga T. Application of human induced pluripotent stem cell-derived intestinal organoids as a model of epithelial damage and fibrosis in inflammatory bowel disease.
    Biol Pharm Bull., 43, 1088–1095 (2020)

  • Koeda A, Iwao T, Nakanishi A, Mizuno S, Yamashita M, Sakai Y, Nakamura K, Matsunaga T.
    Comparison of the inducibility of CYP mRNA exposed to typical inducers in fresh and cryopreserved cynomolgus monkey hepatocytes.
    Drug Metab Pharmacokinet., 35, 304–312 (2020)

  • Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
    Establishment of a novel culture method for maintaining intestinal stem cells derived from human induced pluripotent stem cells.
    Biol Open., 9, bio049064 (2020)

  • Naoya Ieda, and Hidehiko Nakagawa.
    Development of Photoredox-reaction-driven NO-releasing Reagents and Application for Photomanipulation of Vasodilation
    J. Synth. Org. Chem. Jpn., 78(11), 1048-1057 (2020)

  • Naoya Ieda, Yuji Hotta, Ayaka Yamauchi, Atsushi Nishikawa, Takahiro Sasamori, Daisuke Saitoh, Mitsuyasu Kawaguchi, Kazunori Kimura, and Hidehiko Nakagawa.
    Development of a red-light-controllable nitric oxide releaser to control smooth muscle relaxation in vivo
    ACS Chem. Biol., 15(11), 2958-2965 (2020)

  • Shingo Sakamoto, Toru, Komatsu, Rikiya Watanabe, Yi Zhang, Taiki Inoue, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Takaaki Ueno, Takuji Okusaka, Kazufumi Honda, Hiroyuki Noji, and Yasuteru Urano.
    Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples
    Science Advances, 6(11), eaay0888 (2020)

  • Naoya Ieda, and Hidehiko Nakagawa
    Synthesis, evaluation, and biological applications of visible-light-controllable nitric oxide releasers
    Methods in Enzymology, 640, 37-61 (2020)

  • Yuhei Ohta, Mitsuyasu Kawaguchi, Naoya Ieda and Hidehiko Nakagawa
    Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity
    J. Clin. Biochem. Nutr., 67(2), 153-158 (2020)

  • Sumito N, Koeda S, Umezawa N, Inoue Y, Tsukiji S, Higuchi T, Mizuno T.
    Development of cell-penetration PG-surfactants and its application in external peptide delivery to cytosol.
    Bioconjug Chem, 31(3), 821-833 (2020)

  • Kushioka J, Kaito T, Okada R, Ishiguro H, Bal Z, Kodama J, Chijimatsu R, Pye M, Narimatsu M, Wrana JL, Inoue Y, Ninomiya H, Yamamoto S, Saitou T, Yoshikawa H, Imamura T.
    A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone
    Bone Res, 8(1), 41 (2020)

  • Kan’ichiro Ishiuchi, Dai Hirose, Taishi Kondo, Kohei Watanabe, Kazuyoshi Terasaka, Toshiaki Makino
    Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301
    Bioorg. Med. Chem. Lett. 30(4): 126946 (2020)

  • Kan’ichiro Ishiuchi, Ayesha Amber Syed, Yasuhiro Kosuge, Yukio Fujiwara, Toshiaki Makino, Dai Hirose
    Decaturinol A, a new meroterpenoid, isolated from Penicillium decaturense RO050
    Bioorg. Med. Chem. Lett. 30: 127307 (2020)

  • Tsukasa Fueki, Koichiro Tanaka, Kunihiko Obara, Ryudo Kawahara, Takao Namiki, Toshiaki Makino
    The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract
    J. Nat. Med. 74 (4), 722–731 (2020)

  • Masaaki Minami, Hiroshi Takase, Masayo Taira, Toshiaki Makino
    Suppressive effects of Hainosan (Painongsan) against biofilm production by Streptococcus mutans
    Dentistry J. 8(3): 71 (2020)

  • Masaaki Minami, Toshiaki Makino
    Effects of Lonicera japonica flower bud extract on Citrobacter rodentium-induced digestive tract infection
    Medicines. 7(9): 52 (2020)

  • Shirane, M., Shoji, H. Hashimoto, Y., Katagiri, H., Kobayashi, S., Manabe, T.,
    Miyakawa, T., and Nakayama, K. I.
    Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning.
    Mol. Brain, 13: 146-163 (2020)

  • Ibi, D., Nakasai, G., Koide, N., Sawahata, M., Kohno, T., Takaba, R., Nagai, T., Hattori, M., Nabeshima, T., Yamada, K., and Hiramatsu, M.
    Reelin supplementation into the hippocampus rescues abnormal behavior in a mouse model of neurodevelopmental disorder.
    Front. Cell. Neurosci. 14, 285 (2020)

  • Ogino H., Nakajima, T., Hirota, Y., Toriuchi, K., Aoyama, M., Nakajima, K., and Hattori, M.
    The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.
    J. Neurosci. 40, 7625 (2020)

  • Takahiro Yamashiro, Tomoya Yasujima, Hamid M. Said, Hiroaki Yuasa
    pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: implications for absorption in acidic microclimates.
    J. Biol. Chem., 295(50), 16998-17008 (2020)

  • Kalidas Ramamoorthy, Kasin Yadunandam Anandam, Tomoya Yasujima, Padmanabhan Srinivasan, Hamid M. Said
    Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells.
    Am. J. Physiol. Gastrointest. Liver Physiol., 319(3), G323-G332 (2020)

  • Tachita T, Kinoshita S, Ri M, Aoki S, Asano A, Kanamori T, Yoshida T, Totani H, Ito A, Kusumoto S, Komatsu H, Yamagata K, Kubo K, Tohkin M, Fukuda S, Iida S.
    Expression, mutation, and methylation of cereblon-pathway genes at pre- and post-lenalidomide treatment in multiple myeloma.
    Cancer Sci. 111(4):1333-1343 (2020)

  • Sanagawa A, Hotta Y, Kondo M, Nishikawa R, Tohkin M, Kimura K.
    Tumor lysis syndrome associated with bortezomib: A post-hoc analysis after signal detection using the US Food and Drug Administration Adverse Event Reporting System.
    Anticancer Drugs. (2):183-189 (2020)

  • Goto T, Yamazoe Y, Tohkin M.
    Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study. Drug Metab Pharmacokinet. 15: S1347-4367(20)30381-5 (2020)

  • Yamazoe Y, Goto T, Tohkin M.
    Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study
    Drug Metab Pharmacokinet. 35(3):253-265 (2020)

  • J. Nozawa, S. Uda, S. Guo, A. Toyotama, J. Yamanaka, H. Niinomi, and J.Okada,
    Effects of solution flow on the growth of colloidal crystals.
    Langmuir, 36(16), 4324−4331(2020)

  • J. Nozawa, S. Uda, A. Toyotama, J. Yamanaka, H. Niinomi, and J. Okada, Growth and One-Dimensional Heteroepitaxy of Binary Colloidal Crystals. Cryst. Growth Des., 20(5), 3247-3256(2020)

  • Maria Lorna A. De Leoz, David L. Duewer, Adam Fung, Lily Liu, Hoi Kei Yau, Oscar Potter, Gregory O. Staples, Kenichiro Furuki, Ruth Frenkel, Yunli Hu, Zoran Sosic, Peiqing Zhang, Friedrich Altmann, Clemens Gruber, Chun Shao, Joseph Zaia, Waltraud Evers, Stuart Pangelley, Detlev Suckau, Anja Wiechmann, Anja Resemann, Wolfgang Jabs, Alain Beck, John W Froehlich, ChunCui Huang, Yan Li, YaMing Liu, Shiwei Sun, Yaojun Wang, Youngsuk Seo, Hyun Joo An, Niels-Christian Reichardt, Juan Echevarria Ruiz, Stephanie Archer Hartmann, Parastoo Azadi, Len Bell, Zsuzsanna Lakos, Yanming An, John F Cipollo, Maja Pučić-Baković, Jerko Štambuk, Gordan Lauc, Xu Li, Peng George Wang, Andreas Bock, René Hennig, Erdmann Rapp, Marybeth Creskey, Terry Cyr, Miyako Nakano, Taiki Sugiyama, Pui King Amy Leung, Paweł Link Lenczowski, Jolanta Jaworek, Shuang Jake Yang, Hui Zhang, Tim Kelly, Song Klapoetke, Rui Cao, Jin Young Kim, Hyun Kyung Lee, Juyeon Lee, Jong Shin Yoo, Sa Rang Kim, Soo Kyung Suh, Noortje de Haan, David Falck, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer, Robert J. Emery, Radoslaw P. Kozak, Li Phing Liew, Louise Royle, Paulina A. Urbanowicz, Nicolle Packer, Xiaomin Song, Arun Everest-Dass, Erika Lattová, Samanta Cajic, Kathirvel Alagesan, Daniel Kolarich, Toyin Kasali, Viv Lindo, Yuetian Chen, Kudrat Goswami, Brian Gau, Ravi Amunugama, Richard Jones, Corné J. M. Stroop, Koichi Kato, Hirokazu Yagi, Sachiko Kondo, CT Yuen, Akira Harazono, Xiaofeng Shi, Paula Magnelli, Brian T Kasper, Lara K. Mahal, David J. Harvey, Roisin Majella O’Flaherty, Pauline M. Rudd, Radka Saldova, Elizabeth S. Hecht, David C. Muddiman, Jichao Kang, Prachi Bhoskar, Daniele Menard, Andrew Saati, Christine Merle, Steven Mast, Sam Tep, Jennie Truong, Takashi Nishikaze, Sadanori Sekiya, Aaron Shafer, Sohei Funaoka, Masaaki Toyoda, Peter de Vreugd, Cassie Caron, Pralima Pradhan, Niclas Chiang Tan, Yehia Mechref, Sachin Patil, Jeffrey S. Rohrer, Ranjan Chakrabarti, Disha Dadke, Mohammedazam Lahori, Chunxia Zou, Christopher W. Cairo, Bela Reiz, Randy M Whittal, Carlito Lebrilla, Lauren D. Wu, Andras Guttman, Marton Szigeti, Benjamin G. Kremkow, Kelvin Lee, Carina Sihlbom, Barbara Adamczyk, Chunsheng Jin, Niclas G. Karlsson, Jessica Örnros, Göran Larson, Jonas Nilsson, Bernd Meyer, Alena Wiegandt, Emy Komatsu, Helene Perreault, Edward D Bodnar, Nassur Said, Yannis Nicolas Francois, Emmanuelle Leize-Wagner, Sandra Maier, Anne Zeck, Albert J. R. Heck, Yang Yang, Rob Haselberg, Ying Qing Yu, William Alley, Joseph W. Leone, Hua Yuan, and Stephen E. Stein
    NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: Comparison of results from diverse analytical methods
    Mol. Cell. Proteomics 19,11-30 (2020)

  • Saeko Yanaka, Rina Yogo, Hiroki Watanabe, Yuki Taniguchi, Tadashi Satoh, Naoko Komura, Hiromune Ando, Hirokazu Yagi, Nobuhiro Yuki, Takayuki Uchihashi, and Koichi Kato
    On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q
    Int. J. Mol. Sci. 21, 147 (2020)

  • Maho Yagi-Utsumi, Arunima Sikdar, Chihong Song, Jimin Park, Rintaro Inoue, Hiroki Watanabe, Raymond N. Burton-Smith, Toshiya Kozai, Tatsuya Suzuki, Atsuji Kodama, Kentaro Ishii, Hirokazu Yagi, Tadashi Satoh, Susumu Uchiyama, Takayuki Uchihashi, Keehyoung Joo, Jooyoung Lee, Masaaki Sugiyama, Kazuyoshi Murata, and Koichi Kato
    Supramolecular tholos-like architecture constituted by archaeal proteins without functional annotation
    Sci. Rep. 10, Article number: 1540 (2020)

  • Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Taiki Saito, Tokiro Ishikawa, Tetsushi Sakuma, Takashi Yamamoto, Koshi Imami, Yasushi Ishihama, Koichi Kato, Tetsuya Okadar, and Kazutoshi Mori
    EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD
    eLife 9, e53455 (2020)

  • Kazuhiko Yamada, Yoshiki Yamaguchi, Yoshinori Uekusa, Kazumasa Aoki, Ichio Shimada, Takumi Yamaguchi, and Koichi Kato
    Solid-state 17O NMR analysis of synthetically 17O-enriched D-glucosamine
    Chem.Phys. Lett. 749, 137455 (2020)

  • Tadashi Satoh, Miho Nishio, Kousuke Suzuki, Maho Yagi-Utsumi, Yukiko Kamiya, Tsunehiro Mizushima, and Koichi Kato
    Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport
    Acta Crystallogr. Sect. F, 76, 216-221 (2020)

  • Ken Morishima, Aya Okuda, Rintaro Inoue, Nobuhiro Sato, Yosuke Miyamoto, Reiko Urade, Maho Yagi-Utsumi, Koichi Kato, Rina Hirano, Tomoya Kujirai, Hitoshi Kurumizaka, and Masaaki Sugiyama
    Integral approach to biomacromolecular structure by analytical-ultracentrifugation and small-angle scattering
    Communications Biology 3, Article number:294 (2020)

  • Maho Yagi-Utsumi, Saeko Yanaka, Chihong Song, Tadashi Satoh, Chiaki Yamazaki, Haruo Kasahara, Toru Shimazu, Kazuyoshi Murata and Koichi Kato
    Characterization of amyloid β fibril formation under microgravity conditions
    NPJ Microgravity 6, 17 (2020)

  • Methanee Hiranyakorn, Saeko Yanaka, Tadashi Satoh, Thunchanok Wilasri, Benchawan Jityuti, Maho Yagi-Utsumi, and Koichi Kato
    NMR characterization of conformational interconversions of Lys48-linked ubiquitin chains
    Int. J. Mol. Sci. 21, 5351 (2020)

  • Tatsuya Suzuki, Saeko Yanaka, Tokio Watanabe, Gengwei Yan, Tadashi Satoh, Hirokazu Yagi, Takumi Yamaguchi, and Koichi Kato
    Remodeling of the oligosaccharide conformational space in the prebound state to improve lectin-binding affinity
    Biochemistry 59, 3180-3185 (2020)

  • Hirokazu Yagi, Saeko Yanaka, Rina Yogo, Akari Ikeda, Masayoshi Onitsuka, Toshio Yamazaki, Tatsuya Kato, Enoch Y Park, Jun Yokoyama, and Koichi Kato
    Silkworm pupae function as efficient producers of recombinant glycoproteins with stable‐isotope labeling
    Biomolecules 10, 1482 (2020)

  • Ryo Ohtani, Kenichi Kawano, Masanao Kinoshita, Saeko Yanaka, Hikaru Watanabe, Kenji Hirai, Shiroh Futaki, Nobuaki Matsumori, Hiroshi Uji-I, Masaaki Ohba, Koichi Kato, and Shinya Hayami
    Pseudo-membrane jackets: Two-dimensional coordination polymers achieving visible phase separation in cell membrane
    Angew. Chem. Int. Ed. 59, 17931-17937 (2020)

  • MahoYagi-Utsumi, Mahesh S.Chandak, SaekoYanaka, Methanee Hiranyakorn, Takashi Nakamura, Koichi Kato, and Kunihiro Kuwajima,
    Residual structure of unfolded ubiquitin as revealed by hydrogen/deuterium-exchange 2D NMR
    Biophys. J. 119, 2029-2038 (2020)

  • Yukiko Kamiya, Tadashi Satoh, Atsuji Kodama, Tatsuya Suzuki, Keiji Murayama, Hiromu Kashida, Susumu Uchiyama, Koichi Kato, and Hiroyuki Asanuma
    Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-αTNA/RNA and SNA/RNA
    Commun. Chem. 3, 156 (2020)

  • Maho Urano, Megumi Kitahara, Kae Kishi, Eiichi Goto, Tatsuaki Tagami, Toshiro Fukami, Tetsuya Ozeki
    Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method
    Crystals 10(4), 313 (2020)

  • Kaori Fukushige, Tatsuaki Tagami, Munekazu Naito, Eiichi Goto, Shuichi Hirai, Naoyuki Hatayama, Hiroki Yokota, Takao Yasui, Yoshinobu Baba, Tetsuya Ozeki
    International Journal of Pharmaceutics
    Volume 583, 15 119338 (2020)

  • Ryuhei Takahashi, Kenta Sakamoto, Naoki Umezawa, Takashi Umehara, Jun-ichi Matsuo
    Chemoselective arylation of dialkyl diselenides and application to the synthesis of a ε-N, N, N-trimethyllysine derivative
    Eur. J. Org. Chem., 2020(40), 6649-6652 (2020)

  • Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno
    Development of cell-penetration PG-surfactants and its application in external peptide delivery to cytosol Bioconj.
    Chem., 31(3), 821-833 (2020)

  • Nogimori, T., Ogami, K., Oishi, Y., Goda, R., Hosoda, N., Kitamura, Y., Kitade, Y., and Hoshino S.
    ABCE1 acts as a positive regulator of exogenous RNA decay.
    viruses 20 (12) 174 (2020)

  • Tsugawa H, Kabe Y, Kanai A, Sugiura Y, Hida S, Taniguchi S, Takahashi T, Matsui H,Yasukawa Z, Itou H, Takubo K, Suzuki H, Honda K, Handa H, Suematsu M, PLoS
    Short-chain fatty acids bind to apoptosis-associated speck-like protein to
    activate inflammasome complex to prevent Salmonella infection.;
    biology 18(9) e3000813 (2020)

  • Nakajima, Koichiro, TianXiang Gao*, Kazuhiko Kume*, Hiromitsu Iwata, Shuichi Hirai, Chihiro Omachi, Jun Tomita*, Hiroyuki Ogino, Munekazu Naito, and Yuta Shibamoto.
    Fruit Fly, Drosophila Melanogaster, as an In Vivo Tool to Study the Biological Effects of Proton Irradiation.
    Radiation Research 194(2):143–52 (2020)

  • Norimoto, Hiroaki, Lorenz A. Fenk, Hsing-Hsi Li, Maria Antonietta Tosches, Tatiana Gallego-Flores, David Hain, Sam Reiter, Riho Kobayashi, Angeles Macias, Anja Arends, Michaela Klinkmann, and Gilles Laurent.
    A Claustrum in Reptiles and Its Role in Slow-Wave Sleep.
    Nature 578(7795):413–18 (2020)

  • Sakano, Daisuke, Fumiya Uefune, Hiraku Tokuma, Yuki Sonoda, Kumi Matsuura, Naoki Takeda, Naomi Nakagata, Kazuhiko Kume, Nobuaki Shiraki, and Shoen Kume.
    VMAT2 Safeguards Beta-Cells Against Dopamine Cytotoxicity Under High-Fat Diet Induced Stress.
    Diabetes 69(11):2377–91 (2020)

  • Suzuki T, Yasumoto M, Suzuki Y, Asai K, Imaizumi Y, Yamamura H. TMEM16A Ca2+-activated Cl- channel regulates the proliferation and migration of brain capillary endothelial cells.
    Mol Pharmacol. 98(1):61-71 (2020)

  • Suzuki Y, Yamamura H, Imaizumi Y, Clark RB, Giles WR.
    K+ and Ca2+ Channels Regulate Ca2+ Signaling in Chondrocytes: An Illustrated Review.
    Cells. 9(7): E1577 (2020)

  • Yamamura H, Suzuki Y, Yamamura A.
    Pathophysiological roles of TRPC6 channels in pulmonary arterial hypertension.
    Nihon Yakurigaku Zasshi. 155(4):230-235 (2020)

  • Kondo, M., Hotta, Y., Yamauchi, K., Sanagawa, A., Komatsu, H., Iida, S., Kimura, K.
    Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: a retrospective study
    BMC Cancer. 20(1):1117 (2020)

  • Tomita, N., Hotta, Y., Naiki-Ito, A., Hirano, K., Kataoka, T., Maeda, Y., Takahashi, S., Kimura, K.
    The phosphodiesterase 5 inhibitor tadalafil has renoprotective effects in a rat model of chronic kidney disease
    Physiological Reports. 8(17): e14556(2020)

  • Hotta, Y., Takahashi, S., Tokoro, M., Naiki-Ito, A., Maeda, K., Kawata, R., Kataoka, T., Ohta, Y., Hamakawa, T., Takahashi, S., Yasui, T., Kimura, K.
    Anagliptin, a dipeptidyl peptidase-4 inhibitor, improved bladder function and hemodynamics in rats with bilateral internal iliac artery ligation
    Neurourology and Urodynamics. 39(7): 1922-1929 (2020)

  • Kishimoto, T., Kataoka, T., Yamamoto, Y., Asano, G., Fukamoto, A., Hotta, Y., Maeda, Y., Takahashi, M., Kanayama, H.-O., Kimura, K.
    High Salt Intake Impairs Erectile Function in Salt-Sensitive Rats Through Mineralocorticoid Receptor Pathway Beyond Its Effect on Blood Pressure
    Journal of Sexual Medicine. 17(7):1280-1287 (2020)

  • Sugiyama, Y., Naiki, T., Tasaki, Y., Kondo, Y., Kataoka, T., Etani, T., Iida, K., Nozaki, S., Ando, R., Osaga, S., Yasui, T., Kimura, K.
    Prognostic significance of hyponatremia induced by systemic chemotherapy in a hospital-based propensity score-matched analysis
    International Journal of Clinical Oncology. 25(4):541-551 (2020)

  • Sugiyama, Y., Naiki, T., Tasaki, Y., Kataoka, T., Mimura, Y., Kondo, Y., Etani, T., Iida, K., Nozaki, S., Ando, R., Osaga, S., Yasui, T., Kimura, K.
    Effectiveness of continuous monitoring by activity tracker of patients undergoing chemotherapy for urothelial carcinoma
    Cancer Treatment and Research Communications. 25:100245 (2020)

  • Hagiwara, H., Fukuta, H., Niimura, T., Zamami, Y., Ishizawa, K., Kimura, K., Kamiya, T., Ohte, N.
    Comparison of hemorrhagic risk between prasugrel and clopidogrel: A retrospective study using adverse drug event reporting databases
    International Journal of Medical Sciences 17(6):728-233(2020)

  • Sanagawa, A., Hotta, Y., Kondo, M., Nishikawa, R., Tohkin, M., Kimura, K.
    Tumor lysis syndrome associated with bortezomib: A post-hoc analysis after signal detection using the US Food and Drug Administration Adverse Event Reporting System
    Anti-Cancer Drugs 183-189 (2020)

  • 岩尾岳洋，坡下真大，松永民秀
    ヒトiPS細胞を用いた創薬研究支援細胞の作製 Drug Delivery System, 35 (4), 319–330 (2020)

  • 岩尾岳洋，松永民秀
    薬物動態および安全性評価のための小腸–肝臓連結チップ．
    細胞 52 (4), 178–181 (2020)

  • 牧野利明、関根麻理子、田中耕一郎、嶋田沙織、地野充時、田原英一
    医療安全委員会報告〜漢方製剤に関する薬局ヒヤリ・ハット事例
    日本東洋医学雑誌 71(4): 394–401 (2020)

  • 小池宙、松岡尚則、笛木司、牧野利明
    「生姜」と「乾姜」の定義について〜江戸時代と現代日本漢方での違いとその経緯についての一考察
    日本東洋医学雑誌 71(4): 406–417 (2020)

  • 牧野利明、森永 紀、石内勘一郎、吉野鉄大、小川恵子、南澤 潔、渡辺賢治、並木隆雄
    甘草の副作用、偽アルドステロン症の発症メカニズ〜真の原因物質
    18β-glycyrrhetyl-3-O-sulfateの可能性
    phil 漢方 79, 10-13 (2020)

  • 地野充時，牧野利明，関根麻理子，田中耕一郎，嶋田沙織，平崎能郎，四日順子，乗次瑞穂，古屋英治，田原英一
    漢方薬による副作用（偽アルドステロン症、薬物性肝障害、薬物性肺炎）について～日本東洋医学会医療安全委員会活動報告（2019）～
    日本東洋医学雑誌 71(3), 262–267 (2020)

  • 中村智徳，吉野鉄大，堀場裕子，渡辺賢治，三村將，小川恵子，南澤潔，並木隆雄，牧野利明
    漢方薬の副作用に関連した最近の研究成果から〜甘草による偽アルドステロン症の新たな原因物質の可能性
    医薬品相互作用研究 44(2), 75–86 (2020)

  • 山村寿男, 鈴木良明, 山村彩.
    肺動脈性肺高血圧症におけるTRPC6チャネルの病態生理学的役割.
    日薬理誌, 155(4), 230-235 (2020)

  • Ogino H., Yamakage, Y., Kohno, T., Hattori, M.
    Assay for Reelin-cleaving activity of ADAMTS and detection of Reelin and its fragments in brain.
    Methods Mol. Biol. 2043, 105 (2020)

  • H., Nakajima, T., Hirota, Y., Toriuchi, K., Aoyama, M., Nakajima, K., and Hattori, M.
    The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.
    J. Neurosci. 40, 7625 (2020)

  • Kohno, T., Ishii, K., Hirota, Y., Honda, T., Makino, M., Kawasaki, T., Nakajima, K., and Hattori, M.
    Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner.
    J. Neurosci. 43, 8248 (2020)

  • Hojo, H., Yashiro, Y., Noda, Y., Ogami, K., Yamagishi, R., Okada, S., Hoshino, S. and Suzuki, T.
    The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3’ adenylation and selective stabilization of microRNA-122.
    J Biol Chem 295 (2), 390-402　(2020)

  • M. Kawaguchi, T. Okabe, S. Okudaira, K. Hama, K. Kano, H. Nishimasu, H. Nakagawa, R. Ishitani, H. Kojima, O. Nureki, J. Aoki, T. Nagano
    Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain
    J. Med. Chem., 63, 3188-3204 (2020).

  • Shirane, M., Wada, M., Morita, K., Hayashi, N., Kunimatsu, R., Matsumoto, Y., Matsuzaki, F., Nakatsumi, H., Ohta, K., Tamura, Y., and Nakayama, K. I.
    Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
    Nat Commun 11, 4576-4594 (2020)

  • R. Takenaka, T. Yasujima, J. Furukawa, Y. Hishikawa, T. Yamashiro, K. Ohta, K. Inoue, Hiroaki Yuasa
    Functional analysis of the role of equilibrative nucleobase transporter 1 (ENBT1/SLC43A3) in adenine transport in HepG2 cells.
    J. Pharm. Sci., 109, 2622-2628 (2020).

  • C.Miyajima, Y.Kawarada, Y.Inoue, C.Suzuki, K.Mitamura, D.Morishita, N.Ohoka, T.Imamura, H. Hayashi
    Transcriptional coactivator TAZ negatively regulates tumor suppressor p53 activity and cellular senescence.
    Cells, 9, 171 (2020), Doi: 10.3390/cells9010171.

  • S. Nishikawa, Y. Inoue, Y. Hori, C. Miyajima, D. Morishita, N. Ohoka, S. Hida, T. Makino, H. Hayashi
    Anti-inflammatory activity of kurarinone involves induction of HO-1 via the KEAP1/Nrf2 pathway
    Antioxidants, 9, 842 (2020). Doi: 10.3390/antiox9090842

  • Y. Nakatani, K. Negoro, M. Yamauchi, M. Katasho, K. Ishikura, A. Iwaki, K. Tsukada, M. Yamaguchi, A. Uehara, M. Yoshida, K. Ishiuchi, T. Makino, M. Ohsawa, T. Amano
    Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice
    J. Ethnopharmacol. 259: 112963 (2020)

  • K. Ishiuchi, A.Syed, Y. Kosuge, Y. Fujiwara, T. Makino, D. Hirose
    Decaturinol A,a new meroterpenoid, isolated from Penicillium decaturense RO050
    Bioorg. Med. Chem. Lett. 30: 127307 (2020)

  • Y. Genc, D. Sohretoglu, S. Harput, K. Ishiuchi, T. Makino, I. Saracoglu
    Chemical constitiuents of Plantago holosteum and evaluation of their chemotaxonomic significance
    Chem. Natl. Comp. 56: 566–568 (2020)

  • X. Xu, K. Asai, D. Kato, K. Ishiuchi, K. Ding, Y. Tabuchi, M. Ota, T. Makino
    Honey isomaltose contributes to the induction of granulocyte-colony stimulating factor (G-CSF) secretion in the intestinal epithelial cells following honey heating
    Sci. Rep. 10: 15178 (2020)

  • Tohkin M, Saito Y, Yagi S, Asano K, Maekawa K, Osabe M, Iida S, Miyata N.
    Clinical study designs and patient selection methods based on genomic biomarkers:
    Points-to-consider documents.
    Drug Metab Pharmacokinet. 35, 187-190 (2020)

  • Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX.
    MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension Am J Physiol Lung Cell Mol Physiol. 318, L10-L26 (2020)

  • Noda S, Suzuki Y, Yamamura H, Giles WR, Imaizumi Y.
    Roles of LRRC26 as an auxiliary γ1-subunit of large-conductance Ca2+-activated K+ channels in bronchial smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol.318, L366-L375 (2020)

  • H. Yagi, M. Yagi-Utsumi, R. Honda, Y. Ohta, T. Saito, M. Nishio, S. Ninagawa, K. Suzuki,T. Anzai, Y. Kamiya, K. Aoki, M. Nakanishi, T. Satoh, K. Kato Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
    Nature Commun. 11, 1368 (2020).

  • Kohno, T., Ogino, H., Hattori, M.
    Expression and preparation of Reelin and ADAMTS-3 proteins.
    Methods Mol. Biol., 2043: 93-104 (2020). Ogino H., Yamakage, Y., Kohno, T., Hattori, M. Assay for Reelin-cleaving activity of ADAMTS and detection of Reelin and its fragments in brain.
    Methods Mol. Biol., 2043: 105-111 (2020)

2019年度

  • Cho C, Jang J, Kang Y, Watanabe H, Uchihashi T, Kim SJ, Kato K, Lee JY, Song JJ.
    Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone.
    Nat Commun, 10(1), 5764 (2019)

  • Nogimori T, Nishiura K, Kawashima S, Nagai T, Oishi Y, Hosoda N, Imataka H, Kitamura Y, Kitade Y, Hoshino SI
    Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway
    Nucleic Acids Res, 47(1), 432-449 (2019)

  • Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G
    Increase of arginine dimethylation correlates with the progression and prognosis of ALS Neurology, 92(16), e1868-e1877 (2019)

  • Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.
    Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation FASEB J, 33(11), 11821-11835 (2019)

  • Teramae S, Kito A, Shingaki T,Hamaguchi Y, Yano Y, Nakayama T, Kobayashi Y, Kato N, Umezawa N, Hisamatsu Y, Nagano T, Higuchi T.
    Methylene chain ruler for evaluating the regioselectivity of a substrate
    -recognising oxidation catalyst
    Chem Commun, 55(58), 8378-8381 (2019)

  • Kawasaki K, Suzuki Y, Yamamura H, Imaizumi Y.
    Development of a Novel Cell-Based Assay System for High-Throughput Screening of Compounds Acting on Background Two-Pore Domain K+ Channels.
    SLAS Discov. 24, 641-652 (2019)

  • Fukuura K., Inoue Y., Miyajima C., Watanabe S., Tokugawa M., Morishita D., Ohoka N., Komada M., Hayashi H.
    The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21.
    J. Biol. Chem., 294: 16429-16439 (2019).

  • Nishikawa S., Itoh Y., Tokugawa M., Inoue Y., Nakashima K., Hori Y., Miyajima C., Yoshida K., Morishita D., Ohoka N., Inoue K., Mizukami H., Makino T., Hayashi H.
    Kurarinone from Sophora flavescens roots triggers ATF4 activation and cytostatic effects through PERK phosphorylation.
    Molecules, 24: E3110 (2019).

  • Nagasaka, M., Tsuzuki, K., Ozeki Y., Tokugawa M., Ohoka N., Inoue Y., Hidetoshi Hayashi
    Lysine-specific demethylase 1 (LSD1/KDM1A) is a novel target gene of c-Myc.
    Biol. Pharm. Bull., 42: 481-488 (2019)

  • Maekawa K., Ri M., Nakajima M., Sekine A., Ueda R., Tohkin M., Miyata N., Saito Y., Iida S.
    Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with
    multiple myeloma
    Cancer Sci., 110: 3267–3274 (2019)

  • Kawaguchi M., Ieda N., Nakagawa H.
    Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin
    J. Med. Chem., 62: 5434-5452 (2019)

  • Kawaguchi M., Han X., Hisada T., Nishikawa S., Kano K., Ieda N., Aoki J., Toyama T., Nakagawa H.
    Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging and prognostic assessment of malignant breast cancer
    J. Med. Chem., 62: 9254-9269 (2019).

  • Sakai Y, Iwao T, Susukida T, Nukaga T, Takemura A, Sekine S, Ito K, Matsunaga T.
    In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.
    Drug Metab Pharmacokinet., 34: 264-271 (2019)

  • Sakai Y, Okumura H, Iwao T, Watashi K, Ito K, Matsunaga T.
    Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration.
    Toxicol In Vitro., 61:104619 (2019)

  • Iwao T, Matsunaga T.
    Intestinal cells differentiated from human induced pluripotent stem cells for use in drug development studies.,
    Translat Regulat Sci., 1: 24–30, (2019)

  • Hatanaka, Y., Kawasaki, T., Abe, T., Shioi, G., Kohno, T., Hattori, M., Sakakibara, A., Kawaguchi, Y., Hirata, T.
    Semaphorin 6A–Plexin A2/A4 interactions with radial glia regulate migration termination of superficial layer cortical neurons.
    iScience 21: 359 (2019)

  • Yamakage, Y., Kato, M., Hongo, A., Ogino, H., Ishii, K., Ishizuka, T., Kamei, T., Tsuiji, H., Miyamoto, T., Oishi, H., Kohno, T., Hattori, M.
    A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.
    Mol. Cell. Neurosci., 100: 103401 (2019)

  • Ishii, K., Kohno, T., Hattori, M.
    Differential binding of anti-Reelin monoclonal antibodies reveals the characteristics of Reelin protein under various conditions.
    Biochem. Biophys. Res. Commun., 514: 815-820 (2019)

  • Yamakage, Y., Tsuiji, H., Kohno, T., Saito, T., Saido, T.C., Hattori, M.
    Reducing ADAMTS-3 inhibits amyloid β deposition in App knock-in mouse.
    Biol. Pharm. Bull. 42, 354 (2019).

  • Hayashi K., Itoh S., Morikawa A., Onozaki K., Taki S., Tsuji T., Hida S.
    Staphylococcal α-hemolysin does not induce cell damage in murine mast cells but it augments the degranulation induced by FcεRI cross-linking and ionomycin
    Biochem. Biophys. Res. Commun.,508: 263-269 (2019)

  • Kobayashi M., Kitano T., Nishiyama S., Sanjo H., Onozaki K., Taki S., Itoh S., Hida S.
    Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells
    Biochem. Biophys. Res. Commun.,511: 350-355 (2019)

  • Suzuki R., Inoh Y., Yokawa S., Suzuki R., Furuno T., Hirashima N.Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms.Eur. J. Immunol., 49: 2172-2183 (2019)

2018年度

  • Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
    A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
    Nat Commun, 9(1), 2668 (2018)

  • Masato Sawada, Nobuhiko Ohno, Mitsuyasu Kawaguchi, Shih‐hui Huang, Takao Hikita, Youmei Sakurai, Huy Bang Nguyen, Truc Quynh Thai, Yuri Ishido, Yutaka Yoshida, Hidehiko Nakagawa, Akiyoshi Uemura, and, Kazunobu Sawamoto
    PlexinD1 signaling controls morphological changes and migration termination in newborn neurons
    EMBO J, 37(4)e97904 (2018)

  • Y. Hisamatsu, N. Umezawa, H. Yagi, K. Kato, Tsunehiko Higuchi
    Design and Synthesis of a 4-Aminoquinoline-Based Molecular Tweezer That Recognizes Protoporphyrin IX and Iron(III) Protoporphyrin IX and Its Application as a Supramolecular Photosensitizer
    Chem Sci, 9(38), 7455-7467 (2018)

  • Mukaigasa, K., Tsujita, T., Nguyen, V.T., Li, L., Yagi, H., Fuse, Y., Nakajima-Takagi, Y., Kato, K., Yamamoto, M. and Kobayashi, M.
    Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish
    Proc Natl Acad Sci U S A 115(11), 2758-2763 (2018)

  • Fujikake, K., Sawada, M., Hikita, T., Kaneko, N., Herranz-Perez, V.,
    Dohi, N., Homma, N., Osaga, S., Yanagawa, Y., Akaike, T.,
    Garcia-Verdugo, J. M., Sobue, K., Hattori, M., and Sawamoto, K.　
    Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of
    cell-cell Adhesion in the Postnatal Brain
    J Neurosci, 38(19), 4598-4609 (2018)

  • Takahito Furuya, Issey Takehara, Asuka Shimura, Hisanao Kishimoto, Tomoya Yasujima, Kinya Ohta, Yoshiyuki Shirasaka, Hiroaki Yuasa, Katsuhisa Inoue
    Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on D-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of D-luciferin.
    Biochem Biophys Res Commun, 495(3), 2152-2157 (2018)

  • Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, Ohkawa Y, Miyata K, Oike Y, Shirane M, Nishiyama M, Nakayama KI.
    The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis.
    Cell Rep., 23: 1988-2000 (2018)

  • Kabeya T, Qiu S, Hibino M, Nagasaki M, Kodama N, Iwao T, Matsunaga T.
    Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial Cells.
    Drug Metab. Dispos., 46: 1411-1419 (2018)

  • Onozato D, Yamashita M, Nakanishi A, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, Matsunaga T.
    Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells.
    Drug Metab. Dispos., 46: 1572-1580 (2018)

  • Inoue Y, Hasegawa S, Miyachi K, Yamada T, Nakata S, Ipponjima S, Hibi T, Nemoto T, Tanaka M, Suzuki R, Hirashima N.
    Development of 3D imaging technique of reconstructed human epidermis with immortalized human epidermal cell line.
    Exp. Dematol., 27: 563-570 (2018)

  • Hashimoto Y, Shirane M, Nakayama KI.
    TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
    Genes Cells, 23: 418-434 (2018)

  • Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
    Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
    Inflamm. Res., 67: 975-984 (2018)

  • Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI.
    Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer.
    J. Biol. Chem., 293: 6326-6336 (2018)

  • Nagasaka M, Hashimoto R, Inoue Y, Ishiuchi K, Matsuno M, Itoh Y, Tokugawa M, Ohoka N, Morishita D, Mizukami H, Makino T, Hayashi H.
    Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway.
    Molecules, 23: E1394 (2018)

  • Onozato D, Yamashita M, Fukuyama R, Akagawa T, Kida Y, Koeda A, Hashita T, Iwao T, Matsunaga T.
    Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions.
    Stem Cells Dev., 27: 1033-1045 (2018)

  • Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.
    Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.
    Tohoku J. Exp. Med., 244: 133-144 (2018)

2017年度

  • Yokawa S., Suzuki T., Inoue S., Inoh Y., Suzuki R., Kanamori T., Furuno T., Hirashima N
    Visualization of glucagon secretion from pancreatic α cells by bioluminescence video microscopy: identification of secretion sites in the intercellular contact regions.
    Biochem Biophys Res Commun, 485(4), 725-730 (2017)

  • Katsuhiro Kohno, Saotomo Itoh, Akari Hanai, Takemasa Takii, Toshinobu Fujiwara, Kikuo Onozaki, Tsutomu Tsuji, Shigeaki Hida.
    Identification of matrix metalloproteinase 9-interacting sequences in staphylococcal superantigen-like protein 5.
    Biochem Biophys Res Commun, 497(2), 713-718 (2017)

  • Ohnishi T, Shirane M, Nakayama KI.
    SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
    Sci. Rep., 7: 41130 (2017)

  • Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M.
    Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
    J. Neurosci., 37: 3181-3191 (2017)

  • Furukawa J, Inoue K, Ohta K, Yasujima T, Mimura Y, Yuasa H.
    Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase.
    J. Pharmacol. Exp. Ther., 360: 59-68 (2017)

2016年度

  • Sakai, K., Shoji, H., Kohno, T., Miyakawa, T., and Hattori, M.
    Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders.
    J. Neurosci 6, 28636 (2016)

  • Suzuki Y, Ohya S, Yamamura H, Giles WR, Imaizumi Y.
    A new splice variant of large-conductance Ca2+-activated K+ (BK) channel  subunit alters human chondrocyte function.
    J Biol Chem, 291 (46), 24247-24260 (2016)

  • Hirata T, Terai T, Yamamura H, Shimonishi M, Komatsu T, Hanaoka K, Ueno T, Imaizumi Y, Nagano T, Urano Y.
    Protein-coupled fluorescent probe to visualize potassium ion transition on cellular membranes.
    Anal Chem, 88(5), 2693-700 (2016)