共同研究実績

2016年度から開始した公募共同研究(テーマ共同研究と一般共同研究)による業績

  • Ogino H., Yamakage, Y., Kohno, T., Hattori, M.
    Assay for Reelin-cleaving activity of ADAMTS and detection of Reelin and its fragments in brain.
    Methods Mol. Biol. 2043, 105 (2020)
  • H., Nakajima, T., Hirota, Y., Toriuchi, K., Aoyama, M., Nakajima, K., and Hattori, M.
    The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.
    J. Neurosci. 40, 7625 (2020)
  • Kohno, T., Ishii, K., Hirota, Y., Honda, T., Makino, M., Kawasaki, T., Nakajima, K., and Hattori, M.
    Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner.
    J. Neurosci. 43, 8248 (2020)
  • Hojo, H., Yashiro, Y., Noda, Y., Ogami, K., Yamagishi, R., Okada, S., Hoshino, S. and Suzuki, T.
    The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3’ adenylation and selective stabilization of microRNA-122.
    J Biol Chem 295 (2), 390-402 (2020)
  • M. Kawaguchi, T. Okabe, S. Okudaira, K. Hama, K. Kano, H. Nishimasu, H. Nakagawa, R. Ishitani, H. Kojima, O. Nureki, J. Aoki, T. Nagano
    Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain
    J. Med. Chem., 63, 3188-3204 (2020).
  • Shirane, M., Wada, M., Morita, K., Hayashi, N., Kunimatsu, R., Matsumoto, Y., Matsuzaki, F., Nakatsumi, H., Ohta, K., Tamura, Y., and Nakayama, K. I.
    Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation.
    Nat Commun 11, 4576 (2020)
  • R. Takenaka, T. Yasujima, J. Furukawa, Y. Hishikawa, T. Yamashiro, K. Ohta, K. Inoue, Hiroaki Yuasa
    Functional analysis of the role of equilibrative nucleobase transporter 1 (ENBT1/SLC43A3) in adenine transport in HepG2 cells.
    J. Pharm. Sci., 109, 2622-2628 (2020).
  • C.Miyajima, Y.Kawarada, Y.Inoue, C.Suzuki, K.Mitamura, D.Morishita, N.Ohoka, T.Imamura, H. Hayashi
    Transcriptional coactivator TAZ negatively regulates tumor suppressor p53 activity and cellular senescence.
    Cells, 9, 171 (2020), Doi: 10.3390/cells9010171.
  • S. Nishikawa, Y. Inoue, Y. Hori, C. Miyajima, D. Morishita, N. Ohoka, S. Hida, T. Makino, H. Hayashi
    Anti-inflammatory activity of kurarinone involves induction of HO-1 via the KEAP1/Nrf2 pathway
    Antioxidants, 9, 842 (2020). Doi: 10.3390/antiox9090842
  • Y. Nakatani, K. Negoro, M. Yamauchi, M. Katasho, K. Ishikura, A. Iwaki, K. Tsukada, M. Yamaguchi, A. Uehara, M. Yoshida, K. Ishiuchi, T. Makino, M. Ohsawa, T. Amano
    Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice
    J. Ethnopharmacol. 259: 112963 (2020)
  • K. Ishiuchi, A.Syed, Y. Kosuge, Y. Fujiwara, T. Makino, D. Hirose
    Decaturinol A,a new meroterpenoid, isolated from Penicillium decaturense RO050
    Bioorg. Med. Chem. Lett. 30: 127307 (2020)
  • Y. Genc, D. Sohretoglu, S. Harput, K. Ishiuchi, T. Makino, I. Saracoglu
    Chemical constitiuents of Plantago holosteum and evaluation of their chemotaxonomic significance
    Chem. Natl. Comp. 56: 566–568 (2020)
  • X. Xu, K. Asai, D. Kato, K. Ishiuchi, K. Ding, Y. Tabuchi, M. Ota, T. Makino
    Honey isomaltose contributes to the induction of granulocyte-colony stimulating factor (G-CSF) secretion in the intestinal epithelial cells following honey heating
    Sci. Rep. 10: 15178 (2020)
  • Tohkin M, Saito Y, Yagi S, Asano K, Maekawa K, Osabe M, Iida S, Miyata N.
    Clinical study designs and patient selection methods based on genomic biomarkers:
    Points-to-consider documents.
    Drug Metab Pharmacokinet. 35, 187-190 (2020)
  • Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX.
    MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension Am J Physiol Lung Cell Mol Physiol. 318, L10-L26 (2020)
  • Noda S, Suzuki Y, Yamamura H, Giles WR, Imaizumi Y.
    Roles of LRRC26 as an auxiliary γ1-subunit of large-conductance Ca2+-activated K+ channels in bronchial smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol.318, L366-L375 (2020)

  • H. Yagi, M. Yagi-Utsumi, R. Honda, Y. Ohta, T. Saito, M. Nishio, S. Ninagawa, K. Suzuki,T. Anzai, Y. Kamiya, K. Aoki, M. Nakanishi, T. Satoh, K. Kato Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
    Nature Commun. 11, 1368 (2020).
  • Kohno, T., Ogino, H., Hattori, M.
    Expression and preparation of Reelin and ADAMTS-3 proteins.
    Methods Mol. Biol., 2043: 93-104 (2020). 

Ogino H., Yamakage, Y., Kohno, T., Hattori, M. Assay for Reelin-cleaving activity of ADAMTS and detection of Reelin and its fragments in brain.
    Methods Mol. Biol., 2043: 105-111 (2020)
  • Kawasaki K, Suzuki Y, Yamamura H, Imaizumi Y.
    Development of a Novel Cell-Based Assay System for High-Throughput Screening of Compounds Acting on Background Two-Pore Domain K+ Channels.
    SLAS Discov. 24, 641-652 (2019)
  • Fukuura K., Inoue Y., Miyajima C., Watanabe S., Tokugawa M., Morishita D., Ohoka N., Komada M., Hayashi H.
    The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21.
    J. Biol. Chem., 294: 16429-16439 (2019).
  • Nishikawa S., Itoh Y., Tokugawa M., Inoue Y., Nakashima K., Hori Y., Miyajima C., Yoshida K., Morishita D., Ohoka N., Inoue K., Mizukami H., Makino T., Hayashi H.
    Kurarinone from Sophora flavescens roots triggers ATF4 activation and cytostatic effects through PERK phosphorylation.
    Molecules, 24: E3110 (2019).
  • Nagasaka, M., Tsuzuki, K., Ozeki Y., Tokugawa M., Ohoka N., Inoue Y., Hidetoshi Hayashi
    Lysine-specific demethylase 1 (LSD1/KDM1A) is a novel target gene of c-Myc.
    Biol. Pharm. Bull., 42: 481-488 (2019)
  • Maekawa K., Ri M., Nakajima M., Sekine A., Ueda R., Tohkin M., Miyata N., Saito Y., Iida S.
    Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with
    multiple myeloma
    Cancer Sci., 110: 3267–3274 (2019)
  • Kawaguchi M., Ieda N., Nakagawa H.
    Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin
    J. Med. Chem., 62: 5434-5452 (2019)
  • Kawaguchi M., Han X., Hisada T., Nishikawa S., Kano K., Ieda N., Aoki J., Toyama T., Nakagawa H.
    Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging and prognostic assessment of malignant breast cancer
    J. Med. Chem., 62: 9254-9269 (2019).
  • Sakai Y, Iwao T, Susukida T, Nukaga T, Takemura A, Sekine S, Ito K, Matsunaga T.
    In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.
    Drug Metab Pharmacokinet., 34: 264-271 (2019)
  • Sakai Y, Okumura H, Iwao T, Watashi K, Ito K, Matsunaga T.
    Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration.
    Toxicol In Vitro., 61:104619 (2019)
  • Iwao T, Matsunaga T.
    Intestinal cells differentiated from human induced pluripotent stem cells for use in drug development studies.,
    Translat Regulat Sci., 1: 24–30, (2019)
  • Hatanaka, Y., Kawasaki, T., Abe, T., Shioi, G., Kohno, T., Hattori, M., Sakakibara, A., Kawaguchi, Y., Hirata, T.
    Semaphorin 6A–Plexin A2/A4 interactions with radial glia regulate migration termination of superficial layer cortical neurons.
    iScience 21: 359 (2019)
  • Yamakage, Y., Kato, M., Hongo, A., Ogino, H., Ishii, K., Ishizuka, T., Kamei, T., Tsuiji, H., Miyamoto, T., Oishi, H., Kohno, T., Hattori, M.
    A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.
    Mol. Cell. Neurosci., 100: 103401 (2019)
  • Ishii, K., Kohno, T., Hattori, M.
    Differential binding of anti-Reelin monoclonal antibodies reveals the characteristics of Reelin protein under various conditions.
    Biochem. Biophys. Res. Commun., 514: 815-820 (2019)
  • Yamakage, Y., Tsuiji, H., Kohno, T., Saito, T., Saido, T.C., Hattori, M.
    Reducing ADAMTS-3 inhibits amyloid β deposition in App knock-in mouse.
    Biol. Pharm. Bull. 42, 354 (2019).
  • Hayashi K., Itoh S., Morikawa A., Onozaki K., Taki S., Tsuji T., Hida S.
    Staphylococcal α-hemolysin does not induce cell damage in murine mast cells but it augments the degranulation induced by FcεRI cross-linking and ionomycin
    Biochem. Biophys. Res. Commun.,508: 263-269 (2019)
  • Kobayashi M., Kitano T., Nishiyama S., Sanjo H., Onozaki K., Taki S., Itoh S., Hida S.
    Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells
    Biochem. Biophys. Res. Commun.,511: 350-355 (2019)
  • Suzuki R., Inoh Y., Yokawa S., Suzuki R., Furuno T., Hirashima N.
Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms.
Eur. J. Immunol., 49: 2172-2183 (2019)
  • Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, Ohkawa Y, Miyata K, Oike Y, Shirane M, Nishiyama M, Nakayama KI.
    The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis.
    Cell Rep., 23: 1988-2000 (2018)
  • Kabeya T, Qiu S, Hibino M, Nagasaki M, Kodama N, Iwao T, Matsunaga T.
    Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial Cells.
    Drug Metab. Dispos., 46: 1411-1419 (2018)
  • Onozato D, Yamashita M, Nakanishi A, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, Matsunaga T.
    Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells.
    Drug Metab. Dispos., 46: 1572-1580 (2018)
  • Inoue Y, Hasegawa S, Miyachi K, Yamada T, Nakata S, Ipponjima S, Hibi T, Nemoto T, Tanaka M, Suzuki R, Hirashima N.
    Development of 3D imaging technique of reconstructed human epidermis with immortalized human epidermal cell line.
    Exp. Dematol., 27: 563-570 (2018)
  • Hashimoto Y, Shirane M, Nakayama KI.
    TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
    Genes Cells, 23: 418-434 (2018)
  • Kondo S, Mizuno S, Hashita T, Iwao T, Matsunaga T.
    Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
    Inflamm. Res., 67: 975-984 (2018)
  • Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI.
    Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with IκB kinase ϵ (IKKϵ) in colon cancer.
    J. Biol. Chem., 293: 6326-6336 (2018)
  • Nagasaka M, Hashimoto R, Inoue Y, Ishiuchi K, Matsuno M, Itoh Y, Tokugawa M, Ohoka N, Morishita D, Mizukami H, Makino T, Hayashi H.
    Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway.
    Molecules, 23: E1394 (2018)
  • Onozato D, Yamashita M, Fukuyama R, Akagawa T, Kida Y, Koeda A, Hashita T, Iwao T, Matsunaga T.
    Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions.
    Stem Cells Dev., 27: 1033-1045 (2018)
  • Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.
    Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.
    Tohoku J. Exp. Med., 244: 133-144 (2018)
  • Ohnishi T, Shirane M, Nakayama KI.
    SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
    Sci. Rep., 7: 41130 (2017)
  • Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M.
    Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
    J. Neurosci., 37: 3181-3191 (2017)
  • Furukawa J, Inoue K, Ohta K, Yasujima T, Mimura Y, Yuasa H.
    Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase.
    J. Pharmacol. Exp. Ther., 360: 59-68 (2017)