共同研究実績（2021年～）

共同利用・共同研究による業績

2024年度

  • Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP
    Kousuke Takahashi, Taiki Nishiyama, Naoki Umezawa, Yasumichi Inoue, Isamu Akiba, Takehisa Dewa, Atsushi Ikeda, Toshihisa Mizuno
    Chem Commun (Camb) 2024 Jan 23;60(8):968-971. doi: 10.1039/d3cc05347d.

  • Temperature control of the self-assembly process of 4-aminoquinoline amphiphile: Selective construction of perforated vesicles and nanofibers, and structural restoration capabilityYosuke Hisamatsu, Go Toriyama, Katsuhiro Yamamoto, Hiroshi Takase, Tsunehiko Higuchi, Naoki Umezawa
    Chem Eur J. 2024 Jun 25;30(36):e202400134. doi: 10.1002/chem.202400134

  • Target-selective cytosolic delivery of cargo proteins using the VHH-presented OLE-ZIP capsules
    Kousuke Takahashi, Yasumichi Inoue, Shigeaki Hida, Ryuki Hosoda, Naoki Umezawa, Isamu Akiba, Mitsuo Umetsu, Toshihisa Mizuno
    RSC Pharm. 2024 1, 786–796

  • Mangxiao (purified mirabilite, a mineral crude drug) significantly inhibits the occurrence of colorectal cancer by regulating the Lactobacillus-bile acid-intestinal farnesoid X receptor axis based on multi-omics integration analysis
    Xiaohang Zhou, Hui Sun, Junling Ren, Guangli Yan, Le Yang, Honglian Zhang, Haitao Lu, Xinghua Li, Toshiaki Makino, Fengting Yin, Jing Li, XijunWang
    MedComm 2024 Apr 25;5(5): e556. doi: 10.1002/mco2.556.

  • 3-epi-18β-glycyrrhetinic acid or its glucuronide, the metabolites of glycyrrhizinic acid with individual differences, correlated with diagnostic maker for licorice-induced pseudoaldosteronism in humans
    Ryota Sakoda, Kan’ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe, Toshiaki Makino
    Drug Metab Dispos. 2024 Nov 15;52(12):1407-1416. doi: 10.1124/dmd.124.001840.

  • 漢方診療における漢方製剤の多剤併用（ポリファーマシー）問題〜医療安全委員会報告〜
    牧野利明、関根麻理子、嶋田沙織、田中耕一郎、地野充時、田原英一、鍋島茂樹日本東洋医学雑誌、2024 75(2): 144–151
    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment Hagihara, H. et al.
    elife 2024 Mar 26:12:RP89376. doi: 10.7554/eLife.89376.

  • ADAMTS2 regulates radial migration by activating TGF-β signaling in the developing neocortex
    Kaneko, N., Hirai, K., Oshima, M., Yura, K., Hattori, M., Maeda, N., and Ohtaka-Maruyama, C.
    EMBO Rep. 2024 Jul;25(7):3090-3115. doi: 10.1038/s44319-024-00174-x.

  • Reelin ameliorates Alzheimer’s disease, but how?
    Katsuyama, Y. and Hattori, M.
    Neurosci. Neurosci Res. 2024 Nov:208:8-14. doi: 10.1016/j.neures.2024.07.004

  • Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules
    Yamagishi, R., Inagaki, H., Suzuki, J., Hosoda, N., Sugiyama, H., Tomita, K., Hotta, T. and Hoshino, S.
    Nucleic Acids Res. 2024 Aug 27;52(15):9193-9209. doi: 10.1093/nar/gkae497.

  • SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption
    Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, Hiroaki Yuasa
    elife 2024 Nov 7:13:RP98853. doi: 10.7554/eLife.98853.

  • Functional characteristics of equilibrative nucleoside transporter 2 (ENT2/SLC29A2) for the transport of urate as a newly identified substrate
    Isamu Matake, Tomoya Yasujima, Hirotaka Matsuo, Tappei Takada, Katsuhisa Inoue, Takahiro Yamashiro, Hiroaki Yuasa
    Drug Metab Pharmacokinet., in press.

  • Formation of two-dimensional diamond-like colloidal crystals using layer-by-layer electrostatic self-assembly
    M. Fujita, A. Toyotama, T. Okuzono, H. Niinomi, J. Yamanaka
    Soft Matter2024 Jan 31;20(5):985-992. doi: 10.1039/d3sm01278f.

  • Direct Observation of Light Reflection by Titania Particles
    H. Miki, S. Akai, A. Toyotama, T. Okuzono, J. Mata, J. Yamanaka,
    Chem Lett. 53 (2024) upad056. doi: 10.1093/chemle/upad056.

  • Systemic administrations of protamine heal subacute spinal cord injury in mice
    Ozaki T, Sugie T, Suzuki Y, Uchimura K, Suzui M, Sakamoto K, Shirane, M, and Kadomatsu K.
    Neurosci Res. 2024 S0168-0102(24)00151.

  • PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis
    Okujima Y, Watanabe T, Ito T, Inoue Y, Kasai Y, Imai Y, Nakamura Y, Koizumi M, Yoshida O, Tokumoto Y, Hirooka M, Abe M, Kawakami R, Saitou T, Imamura T, Murakami Y, Hiasa Y.
    Sci Rep. 2024 Nov 13;14(1):27768. doi: 10.1038/s41598-024-75142-5.

  • Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA
    Ebara S, Yoshida M, Yamakawa H, Shimokawa K, Inoue Y, Tauchi H, Morishita D.
    Biochem Biophys Res Commun. 2024 Nov 26:735:150608. doi: 10.1016/j.bbrc.2024.150608.

  • ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis
    Nagasaka M, Miyajima C, Inoue Y, Hashiguchi S, Suzuki Y, Morishita D, Aoki H, Toriuchi K, Katayama R, Aoyama M, Hayashi H.
    Biochem Biophys Res Commun. 2024 May 14:708:149789. doi: 10.1016/j.bbrc.2024.149789.

  • Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation and proteasomal degradation
    Tokugawa M, Inoue Y, Aoki H, Miyajima C, Ishiuchi K, Tsurumi K, Kujirai C, Morishita D, Matsuno M, Mizukami H, Ri M, Iida S, Makino T, Aoyama M, Hayashi H.
    J Biochem. 2024 Mar 4;175(3):253-263. doi: 10.1093/jb/mvad085.

  • Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages
    Sawai Y, Suzuki Y, Asagiri M, Hida S, Kondo R, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.

  • Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension
    Shima N, Yamamura A, Fujiwara M, Amano T, Matsumoto K, Sekine T, Okano H, Kondo R, Suzuki Y, Yamamura H.
    Front Cardiovasc Med. 2024 Feb 12:11:1343804. doi: 10.3389/fcvm.2024.1343804.

  • Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4
    Fukuda N, Toriuchi K, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Neurochem Res. 2024 Mar;49(3):800-813. doi: 10.1007/s11064-023-04075-8

  • Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension
    Yamamura A, Fujiwara M, Kawade A, Amano T, Hossain A, Nayeem MJ, Kondo R, Suzuki Y, Inoue Y, Hayashi H, Suzuki S, Sato M, Yamamura H.
    Eur J Pharmacol. 2024 Jun 15:973:176564. doi: 10.1016/j.ejphar.2024.176564.

  • Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands
    Mishima H, Ando S, Kuzuhara H, Yamamura A, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
    Am J Physiol Cell Physiol. 2024 Oct 1;327(4):C1023-C1034. doi: 10.1152/ajpcell.00664.2023.

  • Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review
    Suzuki Y, Giles WR, Zamponi GW, Kondo R, Imaizumi Y, Yamamura H.
    Inflamm Regen. 2024 Dec 27;44(1):50. doi: 10.1186/s41232-024-00363-0.

  • Evaluating intestinal absorption of peptide Met-Lys-Pro in casein hydrolysate using Caco-2 and human iPS cell-derived small intestinal epithelial cells
    Yago T, Yuda N, Tanaka M, Iwao T, Matsunaga T.
    Food Res Int. 2024. 2024 Oct:193:114831. doi: 10.1016/j.foodres.2024.114831.

  • KLF4-mediated macrophage polarization and phenotypic transitions drive intestinal fibrosis in THP-1 monocyte models in vitro
    Kanno T, Katano T, Shimura T, Tanaka M, Nishie H, Fukusada S, Ozeki K, Ogawa I, Iwao T, Matsunaga T, Kataoka H.
    Medicina. 2024 Apr 26;60(5):713. doi: 10.3390/medicina60050713.

  • Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages
    Okada T, Okada A, Aoki H, Onozato D, Kato T, Takase H, Ohshima S, Sugino T, Unno R, Taguchi K, Hamamoto S, Ando R, Shimada IS, Hashita T, Iwao T, Matsunaga T, Yasui T.
    Urolithiasis. 2024 Mar 30;52(1):51. doi: 10.1007/s00240-024-01553-8.

  • Effect of anagliptin on vascular injury in the femoral artery of type 2 diabetic rats
    Noda M, Kikuchi C, Hori E, Iwao T, Nagami C, Takeuchi M, Matsunaga T.
    Biol Pharm Bull. 2024;47(1):204-212. doi: 10.1248/bpb.b23-00706.

  • Utility of human induced pluripotent stem cell-derived small intestinal epithelial cells for pharmacokinetic, toxicological, and immunological studies
    Imakura Y, Mima S, Yamazaki N, Inomata A, Mochizuki S, Iwao T, Matsunaga T.
    Biochem Biophys Res Commun. 2024 Jan 15:692:149356. doi: 10.1016/j.bbrc.2023.149356.

  • Low-adhesion and low-selling hydrogel based on alginate and carbonated water to prevent temporary dilation of wound sites
    Teshima R, Osawa S, Yoshikawa M, Kawano Y, Otsuka H, Hanawa T..
    Int J Biol Macromol. 2024 Jan;254(Pt 3):127928. doi: 10.1016/j.ijbiomac.2023.127928.

  • Feasibility study on the application of pectin as pollen adsorbent to prevent pollinosis
    Ozawa C, Iwami C, Kawano Y, Hanawa T.
    Carbohydr Polym Technol Appl. 2024 8, 100538. doi.org/10.1016/j.carpta.2024.100538

  • Effect of CO2 release behavior on the crosslinking degree of alginate hydrogels prepared with CaCO3 and carbonated water
    Teshima R, Osawa S, Hirose K, Kawano Y, Kikuchi A, Hanawa T, Otsuka H.
    Mater Adv. 2024 5, 6368-6372. doi.org/10.1039/d4ma00257a

  • Differences in time till phlebitis onset in patients injected with ancaron injection or amiodarone hydrochloride injection 150mg “TE”.
    Saito M, Nakashima Y, Hori E, Suzuki T, Ichihara T.
    J Jap Soc Emerg Med. 2024. 27, 80-85 doi: 10.11240/jsem.27.80

  • Effectiveness of Distributing Pocket Cards in Improving the Behavior, Attitude, and Knowledge Regarding Proper Medication Use
    Chihiro Wasa, Kazuhiro Iguchi, Tomoya Tachi, Yoshihiro Noguchi, Aki Hisamatsu, Shingo Katsuno, Hitomi Teramachi,
    Front Pub Health. 2024 11:1296073, doi: 10.3389/fpubh.2023.1296073

  • Probable Effects of Polypharmacy and Equivalent Doses of Psychotropic Drugs on Prevalence of Adverse Drug Events among Psychiatric Inpatients in a General Hospital in Japan
    Keisuke Aoyama, Tomoya Tachi, Satoaki Kubo, Aisa Koyama, Mayuko Watanabe, Satoshi Aoyama, Yoshihiro Noguchi, Kazuhide Tanaka, Masahiro Yasuda, Akihiko Shibata, Takashi Mizui, Hitomi Teramachi
    Hum Psychopharmacol. 2024 May;39(3):e2890. doi: 10.1002/hup.2890

  • Development of a remote health support program by pharmacists and elucidation of its effectiveness: A randomized controlled study
    Tomoya Tachi, Yoshihiro Noguchi, Hitomi Teramachi,
    Biol Pharm Bull. 2024;47(4):771-784. doi: 10.1248/bpb.b23-00566.

  • Impact of Polypharmacy and Risk Factors for Exacerbation of Lower Urinary Tract Symptoms in Patients with Urological Conditions: A Retrospective Study in a Japanese Municipal Hospital
    Shunsuke Yoshizawa, Tomoya Tachi, Yuta Takahashia, Satoshi Aoyama, Yoshihiro Noguchi, Kazuhide Tanaka, Masahiro Yasuda, Takashi Mizui, Hisao Komeda, Tomoaki Yoshimura, Hitomi Teramachi
    Biol Pharm Bull. 2024;47(4):818-826. doi: 10.1248/bpb.b23-00762.

  • CADD-Legacy®ポンプを用いたblinatumomab在宅投与移行プログラムの検討
    藤井祥矢，大澤友裕，平手友章，神田香織，舘知也，水井貴詞，篠田邦大，笠原千嗣，安田昌宏
    癌と化学療法 2024 51，535-539

  • Quality of life assessment and cost-utility analysis of initial chemotherapy for patients with non-Hodgkin’s lymphoma: A prospective analysis
    Kazuhide Tanaka, Masahiro Yasuda, Tomoya Tachi, Yuta Teshigawara, Seiji Inoue, Yoko Ino, Junichi Kitagawa, Yoshihiro Noguchi, Tomoaki Yoshimura, Hitomi Teramachi, Senji Kasahara,
    Oncol Lett. 2024 Jul 11;28(3):430. doi: 10.3892/ol.2024.14564.

  • Questionnaire Survey on Stockpiling Medicines for Disasters in Pharmacies in Gifu City in Anticipation of Nankai Trough Earthquake
    Azumi Kishi, Yoshihiro Noguchi, Tomoya Tachi, Kazuhiro Iguchi, Hitomi Teramachi
    Disaster Med Public Health Prep Actions. 2024 Nov 8:18:e259. doi: 10.1017/dmp.2024.171.

  • SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway
    Yamada S, Hashita T, Yanagida S, Sato H, Yasuhiko Y, Okabe K, Noda T, Nishida M, Matsunaga T, Kanda
    Fluids Barriers CNS. 2024. Apr 8;21(1):32. doi: 10.1186/s12987-024-00533-9.

  • Quantitative Analysis of Therapeutic Antibody Interactions with Fcγ Receptors Using High-Speed Atomic Force Microscopy
    Saeko Yanaka, Hiroki watanabe, Rina Yogo, Mesayamas Kongsema, Sachiko Kondo, Hirokazu Yagi, Takayuki Uchihashi, and Koichi Kato
    Biol Pharm Bull. 2024. Jan 31;47(1):334-338. doi: 10.1248/bpb.b23-00751.

  • Presenilin deficiency results in cellular cholesterol accumulation by impairment of protein glycosylation and NPC1 function
    Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, Dieter Lütjohann, and Jochen Walter
    Int J Mol Sci. 2024 May 16;25(10):5417. doi: 10.3390/ijms25105417.

  • Identification of potential C1-binding sites in the immunoglobulin CL domains
    Saeko Yanaka, Atsuji Kodama, Shigetaka Nishiguchi, Rina Fujita, Jiana Shen, Pornthip Boonsri, Duckyong Sung, Yukiko Isono, Hirokazu Yagi, Yohei Miyanoiri, Takayuki Uchihashi, and Koichi Kato

  • Characterization of protein glycosylation in an Asgard archaeon
    Satoshi Nakagawa, Hiroyuki Imachi, Shigeru Shimamura, Saeko Yanaka, Hirokazu Yagi, Maho Yagi-Utsumi, Hiroyuki Sakai, Shingo Kato, Moriya Ohkuma, Koichi Kato, and Ken Takai
    BBA Adv. 2024 2024 Jul 11:6:100118. doi: 10.1016/j.bbadva.2024.100118.

  • Deciphering the sub-Golgi localization of glycosyltransferases via 3D super-resolution imaging
    Hirokazu Yagi, Seigo Tateo, Taiki Saito, Yusaku Ohta, Emiko Nishi, Saemi Obitsu, Tatsuya Suzuki, Supaphorn Seetaha, Charles Hellec, Akihiko Nakano, Takuro Tojima, and Koichi Kato
    Cell Struct Funct. 2024 Aug 27;49(2):47-55. doi: 10.1247/csf.24008.

  • Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency
    Tadashi Satoh, Maho Yagi-Utsumi, Nozomi Ishii, Tsunehiro Mizushima, Hirokazu Yagi, Ryuichi Kato, Yuriko Tachida, Hiroaki Tateno, Ichiro Matsuo, Koichi Kato, Tadashi Suzuki, and Yukiko Yoshida
    FEBS Lett. 2024 Sep;598(18):2259-2268. doi: 10.1002/1873-3468.15003.

  • N-linked protein glycosylation in Nanobdellati (formerly DPANN) archaea and their hosts Satoshi Nakagawa, Hiroyuki D. Sakai, Shigeru Shimamura, Yoshiki Takamatsu, Shingo Kato, Hirokazu Yagi, Saeko Yanaka, Maho Yagi-Utsumi, Norio Kurosawa, Moriya Ohkuma, Koichi Kato, and Ken Takai
    J Bacteriol. 2024 Sep 19;206(9):e0020524. doi: 10.1128/jb.00205-24.

  • Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils
    Maho Yagi-Utsumi, Yui Kanaoka, Shogo Miyajima, Satoru G Itoh, Katsuhiko Yanagisawa, Hisashi Okumura, Takayuki Uchihashi, and Koichi Kato
    J Am Chem Soc. 2024 Nov 20;146(46):31518-31528. doi: 10.1021/jacs.4c08841.

  • Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway
    Hirokazu Yagi, Rino Yamada1, Taiki Saito, Rena Honda, Rio Nakano, Kengo Inutsuka, Seigo Tateo, Hideo Kusano, Kumiko Nishimura, Saeko Yanaka, Takuro Tojima, Akihiko Nakano, Jun-ichi Furukawa, Maho Yagi-Utsumi, Shungo Adachi, and Koichi Kato
    iScience. 2024 Nov 22;27(12):111457. doi: 10.1016/j.isci.2024.111457.

  • UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
    Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shuichiro Oshita, Shinya Aso, Kazutoshi Matsushita, Mai Taniguchi, Akane Fueki, Moe Yamashiro, Kaoru Sugasawa, Shunsuke Saito, Koshi Imami, Yasuhiko Kizuka, Tetsushi Sakuma, Takashi Yamamoto, Hirokazu Yagi, Koichi Kato, and Kazutoshi Mori
    elife. 2024 Dec 10:12:RP93117. doi: 10.7554/eLife.93117.

  • Exploring domain architectures of human glycosyltransferases: Highlighting the functional diversity of non-catalytic add-on domains
    HirokazuYagi, Katsuki Takagi, and Koichi Kato
    Biochim Biophys Acta Gen Subj. 2024 Oct;1868(10):130687. doi: 10.1016/j.bbagen.2024.130687.

  • Three-dimensional analysis of the intracellular architecture by scanning electron microscopy Daisuke Koga, Satoshi Kusumi, HirokazuYagi, and Koichi Kato
    Microscopy. 2024 Jun 6;73(3):215-225. doi: 10.1093/jmicro/dfad050.

  • Staphylococcal superantigen-like protein 3 triggers murine mast cell adhesion by binding to CD43 and augments mast cell activation
    Sae Kawano, Chisaki Noda, Saotomo Itoh, Ayaka Urabe, Chifumi Fujii, Isamu Ogawa, Ryo Suzuki, Shigeaki Hida
    Genes Cells. 2024 May;29(5):397-416. doi: 10.1111/gtc.13111.

  • Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying
    Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki
    Int J Pharm. 2024 Nov 15:665:124632. doi: 10.1016/j.ijpharm.2024.124632.

  • The Hippo Signaling Pathway Manipulates Cellular Senescence.
    Miyajima C, Nagasaka M, Aoki H, Toriuchi K, Yamanaka S, Hashiguchi S, Morishita D, Aoyama M, Hayashi H, Inoue Y.
    Cells. 2024 Dec 26;14(1):13. doi: 10.3390/cells14010013.

  • Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats
    Takeshita S, Kakita H, Nakamura N, Mori M, Toriuchi K, Aoki H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Exp Neurol. 2024 Jul;377:114781. doi:10.1016/j.expneurol.2024.114781.

  • Promyelinating drugs ameliorate oligodendrocyte pathologies in a mouse model of Krabbe disease.
    Inamura N, Kawai T, Watanabe T, Aoki H, Aoyama M, Nakayama A, Matsuda J, Enokido Y. Mol Genet Metab. 2024 Jul;142(3):108497. doi: 10.1016/j.ymgme.2024.108497.

  • Beacon-based sleep-wake monitoring in dogs.
    Kikusui T, Yagisawa M, Koyama K, Shishikura Y, Miyamoto K, Fujiwara K, Kume K, Nomoto K, Nagasawa M. J Vet Med Sci. 2024 Jun 1;86(6):631-635. doi: 10.1292/jvms.23-0472.

  • Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice.
    Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K, Ozaki N. Transl Psychiatry. 2024 Mar 7;14(1):138. doi: 10.1038/s41398-023-02679-w.

  • Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca2+ imaging.
    Inami C, Haruta M, Ohta Y, Tanaka M, So M, Sobue K, Akay Y, Kume K, Ohta J, Akay M, Ohsawa M. Biochem Biophys Res Commun. 2024 May 14;708:149800. doi: 10.1016/j.bbrc.2024.149800.

  • Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
    Mori D, Inami C, Ikeda R, Sawahata M, Urata S, Yamaguchi ST, Kobayashi Y, Fujita K, Arioka Y, Okumura H, Kushima I, Kodama A, Suzuki T, Hirao T, Yoshimi A, Sobue A, Ito T, Noda Y, Mizoguchi H, Nagai T, Kaibuchi K, Okabe S, Nishiguchi K, Kume K, Yamada K, Ozaki N. Transl Psychiatry. 2024 May 28;14(1):216. doi: 10.1038/s41398-024-02952-6.

  • A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila
    Kobayashi R, Nakane S, Tomita J, Funato H, Yanagisawa M, Kume K.
    Front Neurosci. 2023 Aug 17;17:1181555. doi: 10.3389/fnins.2023.1181555.

  • Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients.
    Nakamura R, Arakawa N, Tanaka Y, Uchiyama N, Sekine A, Mashimo Y, Tsuji K, Kagawa T, Sato K, Watanabe M, Aiso M, Hiasa Y, Takei Y, Ohira H, Ayada M, Tsukagoshi E, Maekawa K, Tohkin M, Saito Y, Takikawa H.
    Hepatol Res. 2023 May;53(5):440-449. doi: 10.1111/hepr.13874.

  • Prediction of Cisplatin-Induced Acute Kidney Injury Using an Interpretable Machine Learning Model and Electronic Medical Record Information
    Ambe K, Aoki Y, Murashima M, Wachino C, Deki Y, Ieda M, Kondo M, Furukawa-Hibi Y, Kimura K, Hamano T, Tohkin M. Clin Transl Sci. 2025 Jan;18(1):e70115. doi: 10.1111/cts.70115.

  • Machine Learning-Based In Silico Prediction of the Inhibitory Activity of Chemical Substances Against Rat and Human Cytochrome P450s
    Ambe K, Nakamori M, Tohno R, Suzuki K, Sasaki T, Tohkin M, Yoshinari K.
    Chem Res Toxicol. 2024 Nov 18;37(11):1843-1850. doi: 10.1021/acs.chemrestox.4c00168.

2023年度

  • The B domain of protein A retains residual structures in 6 M guanidinium chloride as revealed by hydrogen/deuterium-exchange NMR spectroscopy.
    Yanaka S, Yagi-Utsumi M, Kato K, Kuwajima K.
    Protein Sci. 2023 Mar;32(3):e4569. doi: 10.1002/pro.4569.

  • Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages.
    Sawai Y, Suzuki Y, Asagiri M, Hida S, Kondo R, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
    Am J Physiol Cell Physiol. 2024 Jan 1;326(1):C125-C142. doi: 10.1152/ajpcell.00303.2023. Epub 2023 Nov 13.

  • Improved drug transfer into brain tissue via the “nose-to-brain” approach using suspension or powder formulations based on the amorphous solid dispersion technique.
    Suwabe S, Tagami T, Ogawa K, Ozeki T.
    Eur J Pharm Biopharm. 2023 Apr;185:137-147. doi: 10.1016/j.ejpb.2023.02.012. Epub 2023 Feb 24.

  • Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation, and proteasomal degradation.
    Tokugawa M, Inoue Y, Aoki H, Miyajima C, Ishiuchi K, Tsurumi K, Kujirai C, Morishita D, Matsuno M, Mizukami H, Ri M, Iida S, Makino T, Aoyama M, Hayashi H.
    J Biochem. 2023 Nov 8:mvad085. doi: 10.1093/jb/mvad085. Online ahead of print.

  • High preoperative serum strontium levels increase the risk of acute kidney injury after cardiopulmonary bypass.
    Tomita N, Hotta Y, Ito H, Naiki-Ito A, Matsuta K, Yamamoto Y, Ohashi K, Hayakawa T, Sanagawa A, Horita Y, Kondo M, Kataoka T, Takahashi S, Sobue K, Kimura K.
    Clin Exp Nephrol. 2023 Apr;27(4):382-391. doi: 10.1007/s10157-022-02314-w. Epub 2023 Jan 23.

  • Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration.
    Sakakibara Y, Yamashiro R, Chikamatsu S, Hirota Y, Tsubokawa Y, Nishijima R, Takei K, Sekiya M, Iijima KM.
    iScience. 2023 Jan 13;26(2):105968. doi: 10.1016/j.isci.2023.105968. eCollection 2023 Feb 17.

  • Photoinduced NO-release from polymer dots doped with an Ir(III) complex and N-methyl-N-nitroso-4-aminophenol.
    Saitoh D, Suzuki A, Ieda N, Liu Z, Osakada Y, Fujitsuka M, Kawaguchi M, Nakagawa H.
    Org Biomol Chem. 2023 Apr 5;21(14):2983-2989. doi: 10.1039/d3ob00047h.

  • The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
    Yagi-Utsumi M, Itoh SG, Okumura H, Yanagisawa K, Kato K, Nishimura K.
    ACS Chem Neurosci. 2023 Aug 2;14(15):2648-2657. doi: 10.1021/acschemneuro.3c00192. Epub 2023 Jul 23.

  • Successful Noninvasive Respiratory Management of an Infant with Bilateral Choanal Atresia and a Supernumerary Nostril Located on the Columella by a Mouthpiece: A Case Report.
    Nakamura N, Kakita H, Takagi M, Asai S, Asai T, Mori M, Takeshita S, Ueda H, Aoyama M, Kishimoto M, Ito K, Yamada Y.
    Am J Case Rep. 2023 Jun 26;24:e939642. doi: 10.12659/AJCR.939642.

  • Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
    Ishida M, Yamamura A, Fujiwara M, Amano T, Ota M, Hikawa Y, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
    J Pharmacol Sci. 2023 Oct;153(2):84-88. doi: 10.1016/j.jphs.2023.08.001. Epub 2023 Aug 10.

  • Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.
    Fukuda N, Toriuchi K, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Neurochem Res. 2023 Dec 19. doi: 10.1007/s11064-023-04075-8. Online ahead of print.

  • A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila.
    Kobayashi R, Nakane S, Tomita J, Funato H, Yanagisawa M, Kume K.
    Front Neurosci. 2023 Aug 17;17:1181555. doi: 10.3389/fnins.2023.1181555. eCollection 2023.

  • Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate.
    Hisamatsu Y, Cheng F, Yamamoto K, Takase H, Umezawa N, Higuchi T.
    Nanoscale. 2023 Feb 16;15(7):3177-3187. doi: 10.1039/d2nr05756e.

  • Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve-Guided Vancomycin Dosing: A Short Communication.
    Horita Y, Asaoka M, Iida M, Kato H, Wachino C, Mitamura K, Ohashi K, Mimura Y, Hotta Y, Kataoka T, Nakamura A, Kimura K.
    Ther Drug Monit. 2023 Apr 1;45(2):245-250. doi: 10.1097/FTD.0000000000001026.

  • Changes in zinc and manganese concentrations in cisplatin-induced acute kidney injury
    Yamamoto Y, Hotta Y, Tomita N, Naiki-Ito A, Kitagawa A, Kuboshiki U, Hagita T, Noda M, Sanagawa A, Kataoka T, Kondo M, Furukawa-Hibi Y, Takahashi S, Kimura K.
    Biochem Biophys Rep. 2023 Jan 13;33:101422. doi: 10.1016/j.bbrep.2023.101422. eCollection 2023 Mar.

  • Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins.
    Yanaka S, Yogo R, Yagi H, Onitsuka M, Wakaizumi N, Yamaguchi Y, Uchiyama S, Kato K.
    Front Immunol. 2023 Jan 25;14:1090898. doi: 10.3389/fimmu.2023.1090898. eCollection 2023.

  • Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.
    Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.
    J Pharmacol Sci. 2023 Nov;153(3):153-160. doi: 10.1016/j.jphs.2023.08.008. Epub 2023 Sep 1.

  • AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway.
    Owaki R, Aoki H, Toriuchi K, Inoue Y, Hayashi H, Takeshita S, Kakita H, Yamada Y, Aoyama M.
    Exp Cell Res. 2023 Nov 1;432(1):113784. doi: 10.1016/j.yexcr.2023.113784. Epub 2023 Sep 18.

  • Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time.
    Sakai Y, Matsumura M, Iwao T, Matsunaga T.
    In Vitro Cell Dev Biol Anim. 2023 Sep;59(8):606-614. doi: 10.1007/s11626-023-00805-y. Epub 2023 Sep 8.

  • Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils.
    Kitano T, Togawa K, Takemori J, Motoki Y, Kishida K, Itoh S, Takamoto M, Taki S, Hida S.
    Genes Cells. 2023 Mar;28(3):226-236. doi: 10.1111/gtc.13007. Epub 2023 Jan 27.

  • Effects of Hovenia dulcis fruit and peduncle extract on alcohol metabolism.
    Niiya M, Shimato Y, Ohno T, Makino T.
    J Ethnopharmacol. 2024 Mar 1;321:117541. doi: 10.1016/j.jep.2023.117541. Epub 2023 Dec 3.

  • Circadian control of sleep-related neuronal activity in lizards.
    Yamaguchi ST, Hatori S, Kotake KT, Zhou Z, Kume K, Reiter S, Norimoto H.
    PNAS Nexus. 2023 Dec 29;3(1):pgad481. doi: 10.1093/pnasnexus/pgad481. eCollection 2024 Jan.

  • Three-dimensional analysis of the intracellular architecture by scanning electron microscopy.
    Koga D, Kusumi S, Yagi H, Kato K.
    Microscopy (Oxf). 2023 Nov 1:dfad050. doi: 10.1093/jmicro/dfad050. Online ahead of print.

  • Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
    Cho C, Ganser C, Uchihashi T, Kato K, Song JJ.
    Commun Biol. 2023 Sep 28;6(1):993. doi: 10.1038/s42003-023-05373-1.

  • Clustering of charged colloidal particles in the microgravity environment of space.
    Miki H, Ishigami T, Yamanaka J, Okuzono T, Toyotama A, Mata J, Komazawa H, Takeda Y, Minami M, Fujita M, Doi M, Higuchi T, Takase H, Adachi S, Sakashita T, Shimaoka T, Nagai M, Watanabe Y, Fukuyama S.
    NPJ Microgravity. 2023 Apr 29;9(1):33. doi: 10.1038/s41526-023-00280-5.

  • Efficacy of a Red-Light Controllable Nitric Oxide Releaser for Neurogenic Erectile Dysfunction: A Study Using a Rat Model of Cavernous Nerve Injury.
    Mori T, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K.
    World J Mens Health. 2023 Oct;41(4):909-919. doi: 10.5534/wjmh.220146. Epub 2023 Jan 3.

  • Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid.
    Alghurabi H, Jassim Muhammad H, Tagami T, Ogawa K, Ozeki T.
    Int J Pharm. 2023 Dec 15;648:123597. doi: 10.1016/j.ijpharm.2023.123597. Epub 2023 Nov 10.

  • The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic Agent.
    Izumi K, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
    Curr Cancer Drug Targets. 2023;23(11):837-842. doi: 10.2174/1568009623666230522113645.

  • GNRI Sustainability during One Cycle of First-Line Chemotherapy as a Prognostic Indicator in Patients with Metastatic Urothelial Carcinoma.
    Sugiyama Y, Naiki T, Tasaki Y, Mimura Y, Etani T, Noda Y, Nozaki S, Shimizu N, Banno R, Nagai T, Isobe T, Ando R, Moritoki Y, Kataoka T, Odagiri K, Aoki M, Gonda M, Yasui T, Hibi Y.
    Oncology. 2023;101(4):224-233. doi: 10.1159/000529203. Epub 2023 Jan 23.

  • Quantitative analysis of therapeutic antibody interactions with Fcγ receptors using high-speed atomic force microscopy.
    Yanaka S, Watanabe H, Yogo R, Kongsema M, Kondo S, Yagi H, Uchihashi T, Kato K.
    Biol Pharm Bull. 2023 Dec 22. doi: 10.1248/bpb.b23-00751. Online ahead of print.

  • The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons.
    Oya S, Korogi K, Kohno T, Tsuiji H, Danylchuk DI, Klymchenko AS, Niko Y, Hattori M.
    Biol Pharm Bull. 2023;46(12):1820-1825. doi: 10.1248/bpb.b23-00592.

  • Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains.
    Hiranyakorn M, Yagi-Utsumi M, Yanaka S, Ohtsuka N, Momiyama N, Satoh T, Kato K.
    Int J Mol Sci. 2023 Mar 23;24(7):6075. doi: 10.3390/ijms24076075.

  • VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells.
    Sakamoto M, Nagata Y, Furukawa A, Kusada T, Inamoto S, Senda T, Hirashima N, Suzuki R.
    Biochem Biophys Res Commun. 2024 Jan 8;691:149258. doi: 10.1016/j.bbrc.2023.149258. Epub 2023 Nov 23.

  • Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells.
    Shimizu Y, Tamiya-Koizumi K, Tsutsumi T, Kyogashima M, Kannagi R, Iwaki S, Aoyama M, Tokumura A.
    Lipids. 2023 Mar;58(2):93-103. doi: 10.1002/lipd.12366. Epub 2023 Jan 28.

  • IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells.
    Otsuka Y, Kondo T, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, Miyazawa K, Goto S, Aoyama M.
    J Pharmacol Sci. 2023 Jan;151(1):1-8. doi: 10.1016/j.jphs.2022.10.007. Epub 2022 Oct 21.

  • A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group.
    Ieda N, Nakamura A, Tomita N, Ohkubo K, Izumi R, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    RSC Adv. 2023 Sep 4;13(38):26375-26379. doi: 10.1039/d3ra03826b. eCollection 2023 Sep 4.

  • SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner.
    Nagasaka M, Inoue Y, Nagao Y, Miyajima C, Morishita D, Aoki H, Aoyama M, Imamura T, Hayashi H.
    Sci Rep. 2023 Dec 18;13(1):22877. doi: 10.1038/s41598-023-49961-x.

  • Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer.
    Sugimura N, Kubota E, Mori Y, Aoyama M, Tanaka M, Shimura T, Tanida S, Johnston RN, Kataoka H.
    Cancer Immunol Immunother. 2023 Nov;72(11):3593-3608. doi: 10.1007/s00262-023-03509-0. Epub 2023 Aug 1.

  • Molecular Design of FRET Probes Based on Domain Rearrangement of Protein Disulfide Isomerase for Monitoring Intracellular Redox Status.
    Yagi-Utsumi M, Miura H, Ganser C, Watanabe H, Hiranyakorn M, Satoh T, Uchihashi T, Kato K, Okazaki KI, Aoki K.
    Int J Mol Sci. 2023 Aug 16;24(16):12865. doi: 10.3390/ijms241612865.

  • Monocyte-Derived miRNA-1914-5p Attenuates IL-1β-Induced Monocyte Adhesion and Transmigration.
    Toriuchi K, Kihara T, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Shimono Y, Yamada Y, Aoyama M.
    Int J Mol Sci. 2023 Feb 1;24(3):2829. doi: 10.3390/ijms24032829.

  • Formation of two-dimensional diamond-like colloidal crystals using layer-by-layer electrostatic self-assembly.
    Fujita M, Toyotama A, Okuzono T, Niinomi H, Yamanaka J.
    Soft Matter. 2024 Jan 10. doi: 10.1039/d3sm01278f. Online ahead of print.

  • Optimizing adjuvant inhaled chemotherapy: Synergistic enhancement in paclitaxel cytotoxicity by flubendazole nanocrystals in a cycle model approach.
    Miyagi MYS, de Oliveira Faria R, de Souza GB, Lameu C, Tagami T, Ozeki T, Bezzon VDN, Yukuyama MN, Bou-Chacra NA, de Araujo GLB.
    Int J Pharm. 2023 Sep 25;644:123324. doi: 10.1016/j.ijpharm.2023.123324. Epub 2023 Aug 15.

  • Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients.
    Nakamura R, Arakawa N, Tanaka Y, Uchiyama N, Sekine A, Mashimo Y, Tsuji K, Kagawa T, Sato K, Watanabe M, Aiso M, Hiasa Y, Takei Y, Ohira H, Ayada M, Tsukagoshi E, Maekawa K, Tohkin M, Saito Y, Takikawa H.
    Hepatol Res. 2023 May;53(5):440-449. doi: 10.1111/hepr.13874. Epub 2023 Jan 14.

  • Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber.
    Liu Y, Nose I, Terasaka K, Fueki T, Makino T.
    J Nat Med. 2023 Sep;77(4):761-773. doi: 10.1007/s11418-023-01717-7. Epub 2023 Jun 13.

  • Hysteresis behavior in the unfolding/refolding processes of a protein trapped in metallo-cages.
    Nakama T, Rossen A, Ebihara R, Yagi-Utsumi M, Fujita D, Kato K, Sato S, Fujita M.
    Chem Sci. 2023 Feb 22;14(11):2910-2914. doi: 10.1039/d2sc05879k. eCollection 2023 Mar 15.

  • Design of Cell-Adhesive Shellac Derivatives and Endowment of Photoswitchable Cell-Adhesion Properties.
    Sunakawa Y, Kondo M, Yamamoto Y, Inomata T, Inoue Y, Mori D, Mizuno T.
    ACS Appl Bio Mater. 2023 Dec 18;6(12):5493-5501. doi: 10.1021/acsabm.3c00684. Epub 2023 Nov 17.

  • A Combinatorial Code for CPEB-Mediated c-myc Repression.
    Ogami K, Ogawa K, Sanpei S, Ichikawa F, Udagawa T, Hoshino SI.
    Cells. 2023 Oct 6;12(19):2410. doi: 10.3390/cells12192410.

  • Impact of body mass index on the severity of bexarotene-associated hypertriglyceridemia: A post hoc analysis of an open-labeled clinical study of combined bexarotene and phototherapy in Japanese patients with cutaneous T-cell lymphoma.
    Sanagawa A, Hayakawa T, Nishida E, Yamamoto A, Ikumi K, Mori Y, Hotta Y, Kimura K, Furukawa-Hibi Y, Morita A.
    J Dermatol. 2023 Jul;50(7):917-926. doi: 10.1111/1346-8138.16801. Epub 2023 Apr 11.

  • Epidemiology and predictors of hyponatremia in a contemporary cohort of patients with malignancy: a retrospective cohort study.
    Murashima M, Ambe K, Aoki Y, Kasugai T, Tomonari T, Ono M, Mizuno M, Tohkin M, Hamano T.
    Clin Kidney J. 2023 Aug 10;16(11):2072-2081. doi: 10.1093/ckj/sfad189. eCollection 2023 Nov.

  • Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors.
    Seetaha S, Kamonsutthipaijit N, Yagi-Utsumi M, Seako Y, Yamaguchi T, Hannongbua S, Kato K, Choowongkomon K.
    Protein J. 2023 Dec;42(6):741-752. doi: 10.1007/s10930-023-10156-y. Epub 2023 Sep 20.

  • The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells.
    Tozaki Y, Aoki H, Kato R, Toriuchi K, Arame S, Inoue Y, Hayashi H, Kubota E, Kataoka H, Aoyama M.
    Cancers (Basel). 2023 Jan 25;15(3):735. doi: 10.3390/cancers15030735.

  • N-linked glycosylation of flavivirus E protein contributes to viral particle formation.
    Ishida K, Yagi H, Kato Y, Morita E.
    PLoS Pathog. 2023 Oct 11;19(10):e1011681. doi: 10.1371/journal.ppat.1011681. eCollection 2023 Oct.

  • Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes.
    Hozuki S, Yoshioka H, Asano S, Nakamura M, Koh S, Shibata Y, Tamemoto Y, Sato H, Hisaka A.
    Clin Pharmacokinet. 2023 Jun;62(6):849-860. doi: 10.1007/s40262-023-01234-6. Epub 2023 Apr 19.

  • Design and Synthesis of Poly(2,2′-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations.
    Balachandran C, Hirose M, Tanaka T, Zhu JJ, Yokoi K, Hisamatsu Y, Yamada Y, Aoki S.
    Inorg Chem. 2023 Sep 11;62(36):14615-14631. doi: 10.1021/acs.inorgchem.3c01738. Epub 2023 Aug 29.

  • SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells.
    Miyaki R, Yamamura A, Kawade A, Fujiwara M, Kondo R, Suzuki Y, Yamamura H.
    Biochem Biophys Res Commun. 2022 Jun 4;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Epub 2022 Mar 25.

  • Inhibitory effect of Bofutsushosan (Fangfengtongshengsan) extract on the absorption of fructose in rats and mice.
    Takagi K, Sugihira T, Kitamura M, Kawai M, Mitsuguchi Y, Tsukamoto K, Nakanishi H, Makino T.
    J Nat Med. 2023 Jun;77(3):535-543. doi: 10.1007/s11418-023-01697-8. Epub 2023 Apr 11.

  • Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.
    Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC, Chen RP.
    Nat Commun. 2023 Sep 6;14(1):5464. doi: 10.1038/s41467-023-41156-2.

  • Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR.
    Yamaguchi Y, Yamaguchi T, Kato K.
    Adv Neurobiol. 2023;29:163-184. doi: 10.1007/978-3-031-12390-0_6.

  • In vitro-based prediction of human plasma concentrations of food-related compounds.
    Kitaguchi T, Ito M, Ohno K, Ota N, Kobayashi K, Sato H, Iwao T, Matsunaga T, Tanaka M, Hisaka A.
    ALTEX. 2023;40(4):595-605. doi: 10.14573/altex.2302131. Epub 2023 May 12.

  • High Density of N- and O-Glycosylation Shields and Defines the Structural Dynamics of the Intrinsically Disordered Ectodomain of Receptor-type Protein Tyrosine Phosphatase Alpha.
    Chien YC, Wang YS, Sridharan D, Kuo CW, Chien CT, Uchihashi T, Kato K, Angata T, Meng TC, Hsu SD, Khoo KH.
    JACS Au. 2023 Jun 13;3(7):1864-1875. doi: 10.1021/jacsau.3c00124. eCollection 2023 Jul 24.

  • Effect of cigarette smoke on mucosal vaccine response with activation of plasmacytoid dendritic cells: The outcomes of in vivo and in vitro experiments.
    Suzuki F, Maeyama JI, Kubota A, Nishimune A, Horiguchi S, Takii T, Urasaki Y, Shimada I, Iho S.
    Vaccine. 2023 Feb 17;41(8):1447-1456. doi: 10.1016/j.vaccine.2023.01.019. Epub 2023 Jan 24.

2022年度

  • A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes.
    Yamamoto C, Takemura A, Ishii S, Doi A, Saito I, Yamada H, Sakai Y, Matsunaga T, Ito K.
    J Toxicol Sci. 2022;47(1):13-18. doi: 10.2131/jts.47.13.

  • Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan.
    Umezawa F, Natsume M, Fukusada S, Nakajima K, Yamasaki F, Kawashima H, Kuo CW, Khoo KH, Shimura T, Yagi H, Kato K.
    Int J Mol Sci. 2022 Jun 15;23(12):6662. doi: 10.3390/ijms23126662.

  • An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9.
    Saito T, Yagi H, Kuo CW, Khoo KH, Kato K.
    Commun Biol. 2022 Jul 13;5(1):676. doi: 10.1038/s42003-022-03616-1.

  • Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation.
    Ieda N, Yoshikawa Y, Tomita N, Ohkubo K, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
    Chem Commun (Camb). 2022 Jul 26;58(60):8420-8423. doi: 10.1039/d2cc03193k.

  • Three-Dimensional Printing of an Apigenin-Loaded Mucoadhesive Film for Tailored Therapy to Oral Leukoplakia and the Chemopreventive Effect on a Rat Model of Oral Carcinogenesis.
    Takashima H, Tagami T, Kato S, Pae H, Ozeki T, Shibuya Y.
    Pharmaceutics. 2022 Jul 28;14(8):1575. doi: 10.3390/pharmaceutics14081575.

  • Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail.
    Sagae T, Yokogawa M, Sawazaki R, Ishii Y, Hosoda N, Hoshino SI, Imai S, Shimada I, Osawa M.
    J Biol Chem. 2022 May;298(5):101844. doi: 10.1016/j.jbc.2022.101844. Epub 2022 Mar 18.

  • GALAXY ver3: updated web application for glycosylation profiling based on 3D HPLC map.
    Yagi H, Amagasa E, Shiota M, Yamada I, Aoki-Kinoshita KF, Kato K.
    Glycobiology. 2022 Jul 13;32(8):646-650. doi: 10.1093/glycob/cwac025.

  • The SYNGAP1 3’UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK.
    Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G.
    J Neurosci. 2022 Nov 23;42(47):8881-8896. doi: 10.1523/JNEUROSCI.0455-22.2022. Epub 2022 Oct 19.

  • Effect of Topiroxostat on Reducing Oxidative Stress in the Aorta of Streptozotocin-Induced Diabetic Rats
    Noda M, Kikuchi C, Tarui R, Nakamura T, Murase T, Hori E, Matsunaga T.
    Biol Pharm Bull. 2023 Feb 1;46(2):272-278. doi: 10.1248/bpb.b22-00694. Epub 2022 Dec 16.

  • Suspension culture of human induced pluripotent stem cell-derived intestinal organoids using natural polysaccharides.
    Ogawa I, Onozato D, Anno S, Hayashi H, Kanaki T, Iwao T, Matsunaga T.
    Biomaterials. 2022 Sep;288:121696. doi: 10.1016/j.biomaterials.2022.121696. Epub 2022 Aug 7.

  • Peripheral neuropathy in the pre-diabetic state of the type 2 diabetes mouse model (TSOD mice) involves TRPV1 expression in dorsal root ganglions.
    Shida K, Ohsawa M, Takahashi S, Ota H, Tamura T, Kusama N, Nakasone M, Yamazaki H, Sobue K.
    IBRO Neurosci Rep. 2022 Feb 8;12:163-169. doi: 10.1016/j.ibneur.2022.02.001. eCollection 2022 Jun.

  • Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion.
    Yanaka S, Nishiguchi S, Yogo R, Watanabe H, Shen J, Yagi H, Uchihashi T, Kato K.
    Int J Mol Sci. 2022 Feb 14;23(4):2090. doi: 10.3390/ijms23042090.

  • Upregulated ClC3 Channels/Transporters Elicit Swelling-Activated Cl- Currents and Induce Excessive Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension.
    Amano T, Yamamura A, Fujiwara M, Hirai S, Kondo R, Suzuki Y, Yamamura H.
    Biol Pharm Bull. 2022 Nov 1;45(11):1684-1691. doi: 10.1248/bpb.b22-00513. Epub 2022 Aug 20.

  • Clinical Usefulness of the “MN Criteria” – the Clostridioides difficile Infection Severity Scoring System – in the Japanese Setting.
    Asaoka M, Horita Y, Wachino C, Kondo S, Hotta Y, Kataoka T, Sanagawa A, Hayakawa T, Nakamura A, Kimura K.
    Intern Med. 2023 Jan 1;62(1):59-67. doi: 10.2169/internalmedicine.9540-22. Epub 2022 May 31.

  • Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.
    Mitani F, Lin J, Sakamoto T, Uehara R, Hikita T, Yoshida T, Setiawan A, Arai M, Oneyama C.
    Sci Rep. 2022 Apr 23;12(1):6674. doi: 10.1038/s41598-022-10692-0.

  • MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function.
    Hikita T, Uehara R, Itoh RE, Mitani F, Miyata M, Yoshida T, Yamaguchi R, Oneyama C.
    Cancer Sci. 2022 Apr;113(4):1264-1276. doi: 10.1111/cas.15288. Epub 2022 Feb 13.

  • SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells.
    Mitani F, Hayasaka R, Hirayama A, Oneyama C.
    Biol Pharm Bull. 2022;45(10):1572-1580. doi: 10.1248/bpb.b22-00560.

  • Identification of the amino acid residues involved in the species-dependent differences in the pyridoxine transport function of SLC19A3.
    Miyake K, Yasujima T, Takahashi S, Yamashiro T, Yuasa H.
    J Biol Chem. 2022 Aug;298(8):102161. doi: 10.1016/j.jbc.2022.102161. Epub 2022 Jun 17.

  • Glutamine-free mammalian expression of recombinant glycoproteins with uniform isotope labeling: an application for NMR analysis of pharmaceutically relevant Fc glycoforms of human immunoglobulin G1.
    Yanaka S, Yagi H, Yogo R, Onitsuka M, Kato K.
    J Biomol NMR. 2022 Apr;76(1-2):17-22. doi: 10.1007/s10858-021-00387-5. Epub 2022 Jan 3.

  • 2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation.
    Uehara I, Kajita M, Tanimura A, Hida S, Onda M, Naito Z, Taki S, Tanaka N.
    Pharmacol Res Perspect. 2022 Apr;10(2):e00940. doi: 10.1002/prp2.940.

  • A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia.
    Miyagawa T, Tanaka S, Shimada M, Sakai N, Tanida K, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kanbayashi T, Imanishi A, Ikegami A, Kamei Y, Hida A, Wada Y, Miyamoto M, Takami M, Kondo H, Tamura Y, Taniyama Y, Omata N, Mizuno T, Moriya S, Furuya H, Kato M, Kato K, Ishigooka J, Tsuruta K, Chiba S, Yamada N, Okawa M, Hirata K, Kuroda K, Kume K, Uchimura N, Kitada M, Kodama T, Inoue Y, Nishino S, Mishima K, Tokunaga K, Honda M.
    NPJ Genom Med. 2022 Apr 12;7(1):29. doi: 10.1038/s41525-022-00298-w.

  • Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker.
    Ishiuchi K, Morinaga O, Yoshino T, Mitamura M, Hirasawa A, Maki Y, Tashita Y, Kondo T, Ogawa K, Lian F, Ogawa-Ochiai K, Minamizawa K, Namiki T, Mimura M, Watanabe K, Makino T.
    Front Pharmacol. 2022 Nov 24;13:1090327. doi: 10.3389/fphar.2022.1090327. eCollection 2022.

  • Overall structure of fully assembled cyanobacterial KaiABC circadian clock complex by an integrated experimental-computational approach.
    Yunoki Y, Matsumoto A, Morishima K, Martel A, Porcar L, Sato N, Yogo R, Tominaga T, Inoue R, Yagi-Utsumi M, Okuda A, Shimizu M, Urade R, Terauchi K, Kono H, Yagi H, Kato K, Sugiyama M.
    Commun Biol. 2022 Mar 10;5(1):184. doi: 10.1038/s42003-022-03143-z.

  • An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia.
    Ieda N, Sawada M, Oguchi R, Itoh M, Hirakata S, Saitoh D, Nakao A, Kawaguchi M, Sawamoto K, Yoshihara T, Mori Y, Nakagawa H.
    Angew Chem Int Ed Engl. 2023 May 8;62(20):e202217585. doi: 10.1002/anie.202217585. Epub 2023 Apr 12.

  • Time-series transcriptomic screening of factors contributing to the cross-tolerance to UV radiation and anhydrobiosis in tardigrades.
    Yoshida Y, Satoh T, Ota C, Tanaka S, Horikawa DD, Tomita M, Kato K, Arakawa K.
    BMC Genomics. 2022 May 28;23(1):405. doi: 10.1186/s12864-022-08642-1.

  • Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis.
    Kimura Y, Aoki H, Soyama T, Sakuragi A, Otsuka Y, Nomoto A, Yano S, Nishie H, Kataoka H, Aoyama M.
    Med Oncol. 2022 Apr 28;39(5):82. doi: 10.1007/s12032-022-01674-3.

  • Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
    Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C, Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T, Tanaka Y, Matsunaga T.
    Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

  • Drug-interaction between paclitaxel and goshajinkigan extract and its constituents.
    Nakayama A, Tsuchiya K, Xu L, Matsumoto T, Makino T.
    J Nat Med. 2022 Jan;76(1):59-67. doi: 10.1007/s11418-021-01552-8. Epub 2021 Jul 25.

  • PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy.
    Morita K, Wada M, Nakatani K, Matsumoto Y, Hayashi N, Yamahata I, Mitsunari K, Mukae N, Takahashi M, Izumi Y, Bamba T, Shirane M.
    iScience. 2022 Nov 16;25(12):105612. doi: 10.1016/j.isci.2022.105612. eCollection 2022 Dec 22.

  • Effect of Replicative Senescence on the Expression and Function of Transporters in Human Proximal Renal Tubular Epithelial Cells.
    Sanagawa A, Hotta Y, Sezaki R, Tomita N, Kataoka T, Furukawa-Hibi Y, Kimura K.
    Biol Pharm Bull. 2022;45(11):1636-1643. doi: 10.1248/bpb.b22-00322.

  • Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
    Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, Koga D, Takeishi S, Nakatsumi H, Hosen N, Robine S, Taketo MM, Sato T, Nakayama KI.
    Nat Commun. 2022 Mar 21;13(1):1500. doi: 10.1038/s41467-022-29165-z.

  • Biological functions of α2-adrenergic-like octopamine receptor in Drosophila melanogaster.
    Nakagawa H, Maehara S, Kume K, Ohta H, Tomita J.
    Genes Brain Behav. 2022 Jul;21(6):e12807. doi: 10.1111/gbb.12807. Epub 2022 Apr 12.

  • Historical Study for the Differences of Processing of Pinellia ternata Tuber Between China and Japan
    Liu Y, Ota M, Fueki T, Makino T.
    Front Pharmacol. 2022 Jun 20;13:892732. doi: 10.3389/fphar.2022.892732. eCollection 2022.

  • Key Residue for Aggregation of Amyloid-β Peptides.
    Itoh SG, Yagi-Utsumi M, Kato K, Okumura H.
    ACS Chem Neurosci. 2022 Nov 16;13(22):3139-3151. doi: 10.1021/acschemneuro.2c00358. Epub 2022 Oct 27.

  • LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.
    Kawaguchi Y, Matsubayashi J, Kawakami Y, Nishida R, Kurihara Y, Takei K.
    Mol Med. 2022 Dec 12;28(1):154. doi: 10.1186/s10020-022-00581-7.

  • Editorial: Regulatory Mechanisms of Ca2+ Activated Ion Channels and Their Impact on Physiological/Pathophysiological Function.
    Suzuki Y, Ohya S, Giles WR.
    Front Physiol. 2022 Apr 4;13:876327. doi: 10.3389/fphys.2022.876327. eCollection 2022.

  • A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
    Suzuki Y, Ozawa T, Kurata T, Nakajima N, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
    Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2117435119. doi: 10.1073/pnas.2117435119. Epub 2022 Apr 11.

  • Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells.
    Kondo K, Harada Y, Nakano M, Suzuki T, Fukushige T, Hanzawa K, Yagi H, Takagi K, Mizuno K, Miyamoto Y, Taniguchi N, Kato K, Kanekura T, Dohmae N, Machida K, Maruyama I, Inoue H.
    J Biol Chem. 2022 Jun;298(6):101950. doi: 10.1016/j.jbc.2022.101950. Epub 2022 Apr 18.

  • Evaluating the Effects of Low Carbohydrate and High Protein Diet on Erectile Function in Rats.
    Kataoka T, Hidaka J, Suzuki J, Mori T, Nakamura D, Hotta Y, Sanagawa A, Maeda Y, Furukawa-Hibi Y, Kimura K.
    Sex Med. 2022 Apr;10(2):100500. doi: 10.1016/j.esxm.2022.100500. Epub 2022 Mar 5.

  • Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.
    Ota M, Maki Y, Xu LY, Makino T.
    J Ethnopharmacol. 2022 Nov 15;298:115625. doi: 10.1016/j.jep.2022.115625. Epub 2022 Aug 13.

  • Heteroepitaxial fabrication of binary colloidal crystals by a balance of interparticle interaction and lattice spacing.
    Nozawa J, Uda S, Toyotama A, Yamanaka J, Niinomi H, Okada J.
    J Colloid Interface Sci. 2022 Feb 15;608(Pt 1):873-881. doi: 10.1016/j.jcis.2021.10.041. Epub 2021 Oct 13.

  • Interneurons of fan-shaped body promote arousal in Drosophila.
    Kato YS, Tomita J, Kume K.
    PLoS One. 2022 Nov 21;17(11):e0277918. doi: 10.1371/journal.pone.0277918. eCollection 2022.

  • Surface Plasmon Resonance of Two-Dimensional Gold Colloidal Crystals Formed on Gold Plates.
    Aoyama Y, Toyotama A, Okuzono T, Hirashima N, Imai H, Uchida F, Takiguchi Y, Yamanaka J.
    Chem Pharm Bull (Tokyo). 2022;70(2):130-137. doi: 10.1248/cpb.c21-00873.

  • Shin’iseihaito (Xinyiqingfeitang) extract ameliorates ovalbumin-induced murine allergic rhinitis by regulating cytokines.
    Minami M, Konishi T, Takase H, Makino T.
    J Nat Med. 2022 Jan;76(1):244-253. doi: 10.1007/s11418-021-01585-z. Epub 2021 Nov 18.

  • Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer.
    Tagami T, Goto E, Kida R, Hirose K, Noda T, Ozeki T.
    Int J Pharm. 2022 Apr 5;617:121448. doi: 10.1016/j.ijpharm.2022.121448. Epub 2022 Jan 20.

  • Identification of responsible amino acid residues in staphylococcal superantigen-like 12 for the activation of mast cells.
    Kim G, Itoh S, Ito Y, Ohya S, Hida S.
    Genes Cells. 2022 Sep;27(9):559-567. doi: 10.1111/gtc.12973. Epub 2022 Jul 19.

  • Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells.
    Kondo D, Suzuki R, Matsumura A, Meguri H, Tanaka M, Itakura M, Hirashima N.
    Eur J Immunol. 2023 Dec;53(12):e2250360. doi: 10.1002/eji.202250360. Epub 2023 Oct 2.

  • The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa.
    Yamaguchi Y, Wakaizumi N, Irisa M, Maruno T, Shimada M, Shintani K, Nishiumi H, Yogo R, Yanaka S, Higo D, Torisu T, Kato K, Uchiyama S.
    MAbs. 2022 Jan-Dec;14(1):2038531. doi: 10.1080/19420862.2022.2038531.

  • Preparation, Characterization and In Vitro Evaluation of Eudragit S100-Coated Bile Salt-Containing Liposomes for Oral Colonic Delivery of Budesonide.
    Alghurabi H, Tagami T, Ogawa K, Ozeki T.
    Polymers (Basel). 2022 Jun 30;14(13):2693. doi: 10.3390/polym14132693.

  • FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
    Maeda K, Habara M, Kawaguchi M, Matsumoto H, Hanaki S, Masaki T, Sato Y, Matsuyama H, Kunieda K, Nakagawa H, Shimada M.
    Mol Oncol. 2022 Feb;16(4):940-956. doi: 10.1002/1878-0261.13030. Epub 2021 Jun 19.

  • The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
    Nagasaka M, Inoue Y, Yoshida M, Miyajima C, Morishita D, Tokugawa M, Nakamoto H, Sugano M, Ohoka N, Hayashi H.
    FEBS Lett. 2022 Feb;596(4):465-478. doi: 10.1002/1873-3468.14296. Epub 2022 Feb 11.

  • Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption.
    Yoshitomo A, Asano S, Hozuki S, Tamemoto Y, Shibata Y, Hashimoto N, Takahashi K, Sasaki Y, Ozawa N, Kageyama M, Iijima T, Kazuki Y, Sato H, Hisaka A.
    Drug Metab Dispos. 2023 Mar;51(3):318-328. doi: 10.1124/dmd.122.000907. Epub 2022 Dec 7.

  • Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia.
    Kondo T, Aoki H, Otsuka Y, Kawaguchi Y, Waguri-Nagaya Y, Aoyama M.
    J Pharmacol Sci. 2022 Jul;149(3):93-99. doi: 10.1016/j.jphs.2022.03.007. Epub 2022 Apr 16.

  • Protrudin regulates FAK activation, endothelial cell migration and angiogenesis.
    Arora A, Kivelä AM, Wang L, Minkeviciene R, Taskinen JH, Zhang B, Koponen A, Sun J, Shirane M, Zhou Y, Hotulainen P, Raiborg C, Olkkonen VM.
    Cell Mol Life Sci. 2022 Apr 4;79(4):220. doi: 10.1007/s00018-022-04251-z.

  • Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
    Kawade A, Yamamura A, Kondo R, Suzuki Y, Yamamura H.
    J Pharmacol Sci. 2023 Feb;151(2):119-127. doi: 10.1016/j.jphs.2022.12.007. Epub 2022 Dec 23.

  • Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model.
    Tomita N, Hotta Y, Naiki-Ito A, Sanagawa A, Kataoka T, Furukawa-Hibi Y, Takahashi S, Kimura K.
    J Pharmacol Sci. 2022 Jun;149(2):53-59. doi: 10.1016/j.jphs.2022.03.003. Epub 2022 Mar 25.

  • Characterization of Triterpene Saponin Glycyrrhizin Transport by Glycyrrhiza glabra.
    Kato K, Horiba A, Hayashi H, Mizukami H, Terasaka K.
    Plants (Basel). 2022 May 5;11(9):1250. doi: 10.3390/plants11091250.

  • Effect of High Testosterone Levels on Endothelial Function in Aorta and Erectile Function in Rats.
    Kataoka T, Fukamoto A, Hotta Y, Sanagawa A, Maeda Y, Furukawa-Hibi Y, Kimura K.
    Sex Med. 2022 Oct;10(5):100550. doi: 10.1016/j.esxm.2022.100550. Epub 2022 Aug 5.

  • The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes.
    Joyo Y, Kawaguchi Y, Yonezu H, Senda H, Yasuma S, Shiraga H, Nozaki M, Aoyama M, Asai K, Murakami H, Waguri-Nagaya Y.
    Immunol Res. 2022 Apr;70(2):208-215. doi: 10.1007/s12026-022-09261-4. Epub 2022 Jan 10.

  • Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
    Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H.
    Eur J Neurol. 2022 May;29(5):1410-1416. doi: 10.1111/ene.15254. Epub 2022 Feb 6.

  • Effect of steam-processing of the Panax ginseng root on its inducible activity on granulocyte-colony stimulating factor secretion in intestinal epithelial cells in vitro.
    Ding K, Tabuchi Y, Makino T.
    J Ethnopharmacol. 2022 Apr 6;287:114927. doi: 10.1016/j.jep.2021.114927. Epub 2021 Dec 23.

2021年度

  • Tokugawa M, Inoue Y, Ishiuchi K, Kujirai C, Matsuno M, Ri M, Itoh Y, Miyajima C, Morishita D, Ohoka N, Iida S, Mizukami H, Makino T, Hayashi H.
    Periplocin and cardiac glycosides suppress the unfolded protein response.
    Sci. Rep., 11, 9528（2021）

  • Shimeng Qiu, Yaling Li, Shinji Mima, Yuki Imakura, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
    An efficient method for the differentiation of human iPSC-derived endoderm toward enterocytes and hepatocytes.
    Cells, 10, 4, 812 (2021)

  • Sawahata, M., Asano, H., Nagai, T., Ito, N., Kohno, T., Nabeshima, T., Hattori, M., and Yamada, K. (2021)
    Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice.
    Pharmacol. Res. 173, 105832 （2021）

  • Ashikaga T, Ambe K, Suzuki M, Kurimoto M, Yamada T, Tohkin M.
    Establishment of a threshold of toxicological concern concept for skin sensitization by in vitro/in silico approaches.
    Journal of Japanese Cosmetic Science Society. 45(4):331-335(2021)

  • Ambe K, Suzuki M, Ashikaga T, Tohkin M.
    Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning Catboost.
    Regul Toxicol Pharmacol. 125:105019. (2021）

  • Ri M, Iida S, Maruyama D, Sakabe A, Kamei R, Nakashima T, Tohkin M, Osaga S, Tobinai K, Fukuhara N, Miyazaki K, Tsukamoto N, Tsujimura H, Yoshimitsu M, Miyamoto K, Tsukasaki K, Nagai H.
    HLA genotyping in Japanese patients with multiple myeloma receiving bortezomib: An exploratory biomarker study of JCOG1105 (JCOG1105A1).
    Cancer Sci. Dec;112(12):5011-5019 （2021）

  • Nagae, M., Suzuki, K., Yasui, N., Nogi, T., Kohno, T., Hattori, M., and Takagi, L.
    Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization.
    J. Biochem. 169, 555-564 (2021)

  • Tsuneura, Y., Sawahata, M., Itoh, N., Miyajima, R., Mori, D., Kohno, T., Hattori, M., Sobue, A., Nagai, T., Mizoguchi, H., Nabeshoima, T., Ozaki, N., and Yamada, K.
    Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia.
    Neurochem. Int. 144, 104954 (2021)

  • Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Takashi, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka, Tamihide Matsunaga.
    Simultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells
    Drug Metab Dispos., in press (2021)

  • Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H.
    Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes
    Biochem Biophys Res Commun., 537:29-35 (2021)

  • Kawade A, Yamamura A, Fujiwara M, Kobayashi S, Mori S, Horii C, Hiraku A, Suzumura S, Tsukamoto K, Ohara N, Kondo R, Suzuki Y, Yamamura H.
    Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats
    J Pharmacol Sci., 147:81-85 (2021)

  • Suzuki R., Inoh Y., Yokawa S., Furuno T., Hirashima N.
    Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells.
    Biochem. Biophys. Res. Commun. 534, 714-719 (2021)

  • Keiichi Taniguchi, Daisuke Hayashi, Naomi Yasuda, Mao Nakayama, Kaori Yazawa, Shouta Ogawa, Yuji Miyatake, Saki Suda , Haruka Tomita, Miki Tokuda, Saotomo Itoh, Jun-Ichi Maeyama, Naoya Ohara, Saburo Yamamoto, Shigeaki Hida, Kikuo Onozaki, Takemasa Takii
    Comparative Study of the Susceptibility to Oxidative Stress between Two Types of Mycobacterium bovis BCG Tokyo 172.
    mSphere. 6(2):e00111-00121 （2021）

  • Chigusa Kikuchi, Akiko Sakasai-Sakai, Risa Okimura, Hinako Tanaka, Takanobu Takata, Masayoshi Takeuchi, Tamihide Matsunaga,
    Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells.
    Biol Pharm Bull. 44, 10, 1399-1402 (2021)

  • M. Ohsawa, Y. Uezono, A. Inui
    Editorial: Ageing-Related Symptoms, Kampo Medicine, and Treatment.
    Front. Nutr.8 e749320 (2021)

  • M. Ohsawa, T. Makino, Y. Takimoto, A. Inui
    Application of Kampo medicines for the palliation of cancer cachexia.,
    Neuropeptides 90 e102188 （2021）

  • Y. Takeuchi, A.J. Nagy, L. Barcsai, Q. Li, M. Ohsawa, K. Mizuseki, A. Berényi
    The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.,
    Front. Neural Circuits 15 e701080 (2021)

  • Y. Takeuchi, M. Harangozó, L. Pedraza, T. Földi, G. Kozák, Q. Li, A. Berényi
    Closed-loop stimulation of the medial septum terminates epileptic seizures.,
    Brain 144 885-908 (2021)

  • K.C. Robinson, L. V Kemény, G.L. Fell, A.L. Hermann, J. Allouche, W. Ding, A. Yekkirala, J.J. Hsiao, M.Y. Su, N. Theodosakis, G. Kozak, Y. Takeuchi, S. Shen, A. Berenyi, J. Mao, C.J. Woolf, D.E. Fisher
    Reduced MC4R signaling alters nociceptive thresholds associated with red hair.,
    Sci. Adv. 7 abd1310 (2021)

  • T. Gao, J. Li, Y. Watanabe, C. Hung, A. Yamanaka, K. Horie, M. Yanagisawa, M. Ohsawa, K. Kume
    GI-SleepNet: A Highly Versatile Image-Based Sleep Classification Using a Deep Learning Algorithm
    Clocks & Sleep 3 581-597 (2021)

  • T. Muto, M.I. Yoshizawa, C. Kim, K. Kume,
    Sleep-improving effects of a novel motion mattress
    Sleep Biol. Rhythms 19 247-253 (2021)

  • A. Ambati, R. Hillary, S. Leu-Semenescu, H.M. Ollila, L. Lin, E.H. During, N. Farber, T.J. Rico, J. Faraco, E. Leary, A.N. Goldstein-Piekarski, Y.-S. Huang, F. Han, Y. Sivan, M. Lecendreux, P. Dodet, M. Honda, N. Gadoth, S. Nevsimalova, F. Pizza, T. Kanbayashi, R. Peraita-Adrados, G.D. Leschziner, R. Hasan, F. Canellas, K. Kume, M. Daniilidou, P. Bourgin, D. Rye, J.L. Vicario, B. Hogl, S.C. Hong, G. Plazzi, G. Mayer, A.M. Landtblom, Y. Dauvilliers, I. Arnulf, E.J.-M. Mignot
    Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci,,
    Proc. Natl. Acad. Sci. e2005753118 (2021)

  • N. Kon, H.-T. Wang, Y.S. Kato, K. Uemoto, N. Kawamoto, K. Kawasaki, R. Enoki, G. Kurosawa, T. Nakane, Y. Sugiyama, H. Tagashira, M. Endo, H. Iwasaki, T. Iwamoto, K. Kume, Y. Fukada
    Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms.,
    Sci. Adv. 7 eabe8132 (2021)

  • Sai, K., Nakatani, E., Iwama, Y., Hiraoka, S., Tohkin, M., Uyama, Y., Saito, Y.
    Efficacy comparison for a schizophrenia and a dysuria drug among East Asian populations: A retrospective analysis using multi-regional clinical trial data
    Therapeutic Innovation & Regulatory Science 55:523-538. (2021）

  • Asano K., Aoi Y., Kamada S., Uyama Y., Tohkin M.
    Points to consider for implementation of the ICH
    E17 guideline: learning from past multi-regional clinical trials (MRCTs) in Japan. Clin Pharmacol Ther. 109:1555-1563. (2021）

  • Yamazoe Y, Tohkin M.
    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
    Drug Metab Pharmacokinet. 38:100357. (2021）

  • Toshie Kihara, Kohki Toriuchi, Hiromasa Aoki, Hiroki Kakita, Yasumasa Yamada, Mineyoshi Aoyama
    Interleukin-1β enhances cell adhesion in human endothelial cells via microRNA-1914-5p suppression
    Biochemistry and Biophysics Reports　27:101046 (2021）

  • Takao Kondo, Yuto Otsuka, Hiromasa Aoki, Yoh Goto, Yohei Kawaguchi, Yuko Waguri-Nagaya, Ken Miyazawa, Shigemi Goto, Mineyoshi Aoyama
    The Inducible Nitric Oxide Synthase Pathway Promotes Osteoclastogenesis under Hypoxic Culture Conditions
    The American Journal of Pathology 191:2072-2079 (2021）

  • Ken Mizuguchi, Hiromasa Aoki, Mineyoshi Aoyama, Yohei Kawaguchi, Yuko Waguri-Nagaya, Nobuyuki Ohte, Kiyofumi Asai
    Three-dimensional spheroid culture induces apical-basal polarity and the original characteristics of immortalized human renal proximal tubule epithelial cells
    Experimental Cell Research 404:112630 (2021）

  • Satoru Takeshita, Hiroki Kakita, Kohki Toriuchi, Hiromasa Aoki, Hiroko Ueda, Akihiko Wakatsuki, Yasumasa Yamada, Mineyoshi Aoyama
    Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small-for-gestational-age rats
    British journal of haematology 192(4):e105-e108 (2021）

  • Tatsuki Soyama, Akira Sakuragi, Daisuke Oishi, Yuka Kimura, Hiromasa Aoki, Akihiro Nomoto, Shigenobu Yano, Hirotada Nishie, Hiromi Kataoka, Mineyoshi Aoyama
    Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages
    Translational oncology 14:101005 (2021）

  • Takao Namiki, Shin Takayama, Ryutaro Arita, Tadashi Ishii, Mosaburo Kainuma, Toshiaki Makino, Masaru Mimura, Tetsuhiro Yoshino, Tatsuya Nogami, Makoto Arai, Juichi Sato, Koichiro Tanaka, Hajime Nakae, Hidetoshi Igari, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Masahiko Nezu, Takashi Ito
    A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)
    Trials. 22: 23 (2021）

  • Kan’ichiro Ishiuchi, Osamu Morinaga, Tetsuhiro Yoshino, Miaki Mitamura, Asuka Hirasawa, Yasuhito Maki, Yuuna Tashita, Tsubasa Kondo, Kakuyou Ogawa, Fangyi Lian, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Takao Namiki, Masaru Mimura, Kenji Watanabe, Toshiaki Makino
    Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker
    Frontiers Pharmacol. 12, 688508, 202 (2021）

  • Misato Ota, Hao Ni, Yasuhito Maki, Daiki Kato, Shohei Moriguchi, Shuto Nakayama, Yuki Oiwa, Kan’ichiro Ishiuchi, Toshiaki Makino
    Binding activity of Valeriana fauriei root extract on GABAA receptor flunitrazepam sites and distribution of its active ingredients in the brain of mice – a comparison with that of V. officinalis root
    J. Ethnopharmacol. 278, 114262 (2021）

  • Manhui Zhang, Kouhei Kobayashi, Haruki Atsumi, Yuma Katada, Yusuke Nakane, Junfeng Chen, Ryo Nagano, Naoya Kadofusa, Taeko Nishiwaki-Ohkawa, Naohiro Kon, Tsuyoshi Hirota, Ayato Sato, Toshiaki Makino, Takashi Yoshimura
    Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine
    Sci. Rep. 11, 21038 (2021）

  • Secil Sarikaya Aydin, Vahap Murat Kutluay, Toshiaki Makino, Makoto Inoue, Ummuhan Sebnem Harput, Iclal Saracoglu
    Isolation of potential liver x receptor alpha agonist and antioxidant compounds from Hypericum microcalycinum Boiss. & Heldr.
    J. Facul. Pharma. Istanbul Univ. 51, 98–105 (2021）

  • Shin Takayama, Akiko Kikuchi, Toshiaki Makino, Mosaburo Kainuma, Takao Namiki, Takashi Ito
    Basic pharmacological mechanisms and clinical evidence of the efficacy of Hochuekkito against infectious diseases and its potential for use against COVID-19
    Tradit. Kampo 8: 3–21 (2021）

  • Tetsuhiro Yoshino, Saori Shimada, Masato Homma, Toshiaki Makino, Masaru Mimura, Kenji Watanabe
    linical risk factors of licorice-induced pseudoaldosteronism based on the concentrations of glycyrrhizin-metabolites; a narrative review
    Frontiers Nutr. 8: 719197 (2021）

  • 笛木司、田中耕一郎、千葉浩輝、小原陣内、柴山周乃、並木隆雄、別府正志、牧野利明
    古典に記載された方剤を煎じる際に指定されている水量の意味－通脈四逆加猪胆汁湯と茯苓四逆湯のアコニチン型アルカロイド濃度に着目して－
    日本東洋医学雑誌、72(2): 107–118 (2021）

  • 関根麻理子、牧野利明、田中耕一郎、嶋田沙織、四日順子、古屋英治、地野充時、田原英一
    医療安全委員会報告〜漢方製剤に関する医療機関からの医療事故情報及びヒヤリ・ハット事例
    日本東洋医学雑誌、72(2): 182–207 (2021）

  • 牧野利明、安井廣迪、並木隆雄
    欧米の薬局方に収載された日本の医療用漢方製剤の原料生薬について – 東アジア各国の薬局方での名称と基原の比較
    日本東洋医学雑誌、72(4): 402–414 (2021）

  • Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H.
    Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes.
    Biochem Biophys Res Commun. 537:29-35 (2021)

  • Hashimoto D, Hirashima T, Yamamura H, Kataoka T, Fujimoto K, Hyuga T, Yoshiki A, Kimura K, Kuroki S, Tachibana M, Suzuki K, Yamamoto N, Morioka S, Sasaki T, Yamada G.
    Dynamic erectile responses of a novel penile organ model utilizing TPEM.
    Biol Reprod. 104(4):875-886 (2021)

  • Suzuki T, Suzuki Y, Asai K, Imaizumi Y, Yamamura H.
    Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl- channels.
    J Pharmacol Sci. 146:65-69 (2021)

  • Kataoka T, Mori T, Suzuki J, Kawaki Y, Kito Y, Hotta Y, Kawade Y, Maeda Y, Kimura K.
    Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction.
    J Sex Med. 18,1337-1345 (2021)

  • Ota Y, Kubota Y, Hotta Y, Matsumoto M, Matsuyama N, Kato T, Hamakawa T, Kataoka T, Kimura K, Sawamoto K, Yasui T.
    Change in the Central Control of the Bladder Function of Rats with Focal Cerebral Infarction induced by Photochemically-Induced Thrombosis.
    PLoS One. 16:e0255200 (2021)

  • Mori T, Hotta Y, Nakamura D, Yahagi R, Kataoka T, Kimura K.
    Enhancement of the RhoA/Rho Kinase Pathway is Associated with Stress-Related Eerectile Dysfunction in a Restraint Water-Immersion Stress Model.
    Physiol Rep. 9:e15064. (2021)

  • Sanagawa A, Hotta Y, Mori N, Tomita N, Kataoka T, Tohkin M, Kimura K.
    BRAF/MEK inhibitor-associated Nephrotoxicity in a Real-World Setting and Human Kidney Cells.
    Anticancer Drugs. 32:1076-1083 (2021)

  • Maeda K, Hotta Y, Kawata R, Kataoka T, Kimura K.
    Detrusor Underactivity Causes Neurogenic Voiding Dysfunction in a Rat Bilateral Accessory Nerve-Injury Model.
    J Pharmacol Sci. 146:116-119 (2021)

  • Maeda K, Hotta Y, Ieda N, Kataoka T, Nakagawa H, Kimura K.
    Control of Rat Bladder Neck Relaxation with NORD-1, a Red Light–Reactive Nitric Oxide Releaser: In Vitro Study.
    J Pharmacol Sci. 146:226-232 (2021)

  • Kataoka K, Hotta Y, Yamamoto Y, Fukamoto A, Takeuchi M, Maeda Y, Kimura K.
    Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats.
    Sex Med. 9:100348 (2021)

  • Kawata R, Hotta Y, Maeda K, Kataoka T, Kimura K.
    Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats.
    Nutrients. 13:539 (2021)

  • Maeda K, Hotta Y, Shibayama M, Kawata R, Kataoka T, Matsumoto S, Yamamoto T, Kimura K.
    Impairment of Accessory Nerves around Major Pelvic Ganglion leading to Overflow Urinary Incontinence in Rats.
    Neurourol Urodyn. 40:624-631 (2021)

  • Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohono E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M.
    Filtrated Adipose Tissue‑Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice.
    Dig Dis Sci. 66:1034-1044 (2021)

  • Siriluk Ratanabunyong, Niran Aeksiri, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kiattawee Choowongkomol, and Supa Hannongbua,
    Characterization of new DNA aptamers for anti-HIV-1 reverse transcriptase
    ChemBioChem 22, 915-923 (2021)

  • Saeko Yanaka, Yoshiki Yamaguchi, Takeshi Takizawa, Yohei Miyanoiri, Rina Yogo, Ichio Shimada, and Koichi Kato
    NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein
    Biomol. NMR Assign. 15, 187-192 (2021)

  • Siriluk Ratanabunyong, MahoYagi-Utsumi, SaekoYanaka, Koichi Kato, Kiattawee Choowongkomon, and Supa Hannongbua
    Investigation of RT1t49 aptamer binding to human immunodeficiency virus 1 reverse transcriptase
    J. Curr. Sci. and Technol. 11, 51-59 (2021)

  • Aya Okuda, Rintaro Inoue, Ken Morishima, Tomohide Saio, Yasuhiro Yunoki, Maho Yagi-Utsumi, Hirokazu Yagi, Masahiro Shimizu, Nobuhiro Sato, Reiko Urade, Koichi Kato, and Masaaki Sugiyama
    Deuteration aiming for neutron scattering
    Biophys. Physicobiol. 18, 16-27 (2021)

  • Maho Yagi-Utsumi, Tomohiro Tanaka, Yoko Otsubo, Akira Yamashita, Shinji Yoshimura, Motohiro Nishida, and Koichi Kato
    Cold atmospheric plasma modification of amyloid β
    Int. J. Mol. Sci. 22, 3116 (2021)

  • Chihong Song, Tadashi Satoh, Taichiro Sekiguchi, Koichi Kato and Kazuyoshi Murata
    Structural fluctuations of the human proteasome α7 homo-tetradecamer double ring imply the proteasomal α-ring assembly mechanism
    Int. J. Mol. Sci. 22, 4519 (2021)

  • Tokio Watanabe, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, and Koichi Kato
    Comprehensive characterization of oligosaccharide conformational ensembles with conformer classification by free-energy landscape via reproductive kernel Hilbert space
    Phys. Chem. Chem. Phys. 23, 9753-9760 (2021)

  • Ryo Ohtani, Yuka Anegawa, Hikaru Watanabe, Yutaro Tajima, Masanao Kinoshita, Nobuaki Matsumori, Kenichi Kawano, Saeko Yanaka, Koichi Kato, Masaaki Nakamura, Masaaki Ohba, and Shinya Hayami
    Metal complex lipids for fluid-fluid phase separation in co-assembled phospholipid membranes
    Angew. Chem. Int. Ed. 70, 13603-13608 (2021)

  • Kazuhisa Miyazawa, Satoru G. Itoh, Hiroki Watanabe, Takayuki Uchihashi, Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kazuharu Arakawa, and Hisashi Okumura
    Tardigrade secretory-abundant heat-soluble protein has a flexible β‑barrel structure in solution and keeps this structure in dehydration
    J. Phys. Chem. B. 125, 9145-9154 (2021)

  • Nobuhiro Sato, Rina Yogo, Saeko Yanaka, Anne Martel, Lionel Porcar, Ken Morishima, Rintaro Inoue, Taiki Tominaga, Takao Arimori, Junichi Takagi, Masaaki Sugiyama, and Koichi Kato
    A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems
    J. Biochem. 169, 701-708 (2021).

  • Fumiya Yamasakia, Fumiko Umezawa, Tomohiro Sensui, Masashi Anzo, Hirohito Abo, Chu-Wei Kuo, Kay-Hooi Khoo, Koichi Kato, Hirokazu Yagi, and Hiroto Kawashima
    Establishment of a novel monoclonal antibody against truncated glycoforms of α-dystroglycan lacking matriglycans
    Biochem. Biophys. Res. Commun. 579, 8-14

  • Maho Yagi-Utsumi, Kazuhiro Aoki, Hiroki Watanabe, Chihong Song, Seiji Nishimura, Tadashi Satoh, Saeko Yanaka, Christian Ganser, Sae Tanaka, Vincent Schnapka, Ean Wai Goh, Yuji Furutani, Kazuyoshi Murata, Takayuki Uchihashi, Kazuharu Arakawa and Koichi Kato
    Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
    Sci. Rep. 11, Article number: 21328 (2021).

  • Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, and Kazutoshi Mori
    Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD
    eLife 10, e70357 (2021)

  • Yumi Murai, Maho Yagi-Utsumi, Masayuki Fujiwara, Sae Tanaka, Masaru Tomita, Koichi Kato and Kazuharu Arakawa
    Multiomics study of a heterotardigrade, Echinisicus testudo, suggests the possibility of convergent evolution of abundant heat- soluble proteins in Tardigrada
    BMC Genomics 22, 813 (2021).

  • Daishi Fujita, Ryoto Suzuki, Yuya Fujii, Mayu Yamada, Takahiro Nakama, Akimasa Matsugami, Fumiaki Hayashi, Jing-Ke Weng, MahoYagi-Utsumi, and MakotoFujita
    Protein stabilization and refolding in a gigantic self-assembled cage
    Chem 7, 2672-2683 (2021)

  • Hiroki Kitagawa, Masaki Kikuchi, Shin Sato, Hisami Watanabe, Naoki Umezawa, Maiko Kato, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi, “Structure-based identification of potent lysine-specific demethylase 1 inhibitor peptides and temporary cyclization to enhance proteolytic stability and cell growth-inhibitory activity”,
    J. Med. Chem., 64, 7, 3707-3719 (2021)

  • Yosuke Hisamatsu, Koki Otani, Hiroshi Takase, Naoki Umezawa, Tsunehiko Higuchi, “Fluorescence response and self-assembly of a tweezer-type synthetic receptor triggered by complexation with heme and its catabolites”,
    Chem. Eur. J., 27, 21, 6489-6499 (2021)

  • Tomoki Kitagawa, Takashi Nishio, Yuko Yoshikawa, Naoki Umezawa, Tsunehiko Higuchi, Chwen-Yang Shew, Takahiro Kenmotsu, Kenichi Yoshikawa, “Effects of structural isomers of spermine on the higher-order structure of DNA and gene expression”,
    Int. J. Mol. Sci., 22, 5, 2355-2369 (2021)

  • Kazuya Matsuo, Sampreeth Thayyil, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, and Nobuyuki Tamaoki
    A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole
    Chem. Commun., 57(93), 12500-12503 (2021)

  • Mitsuyasu Kawaguchi, Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami, and Hidehiko Nakagawa
    Synthesis of fluorescence probes targeting tumor-suppressor protein FHIT and identification of apoptosis-inducing FHIT inhibitors
    J. Med. Chem., 64, 9567-9576 (2021)

  • Kasin Yadunandam Anandam, Padmanabhan Srinivasan, Tomoya Yasujima, Saleh Al-Juburi, Hamid M. Said
    Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).
    Am. J. Physiol. Gastrointest. Liver Physiol., 320, G108-G116 (2021)

  • Mitsuyasu Kawaguchi , Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami, Hidehiko Nakagawa
    Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors
    J Med Chem., 64, 9567-9576 (2021)

  • Sato, T., Cheng, C.-L., Park, H.-W., Kao Yang, Y.-H., Min-Suk Yang, M.-S., Fujita, M., Kumagai, Y., Tohkin, M., Saito, Y., Sai, K.
    Real World Evidence of Population Differences in Allopurinol- related Severe Cutaneous Adverse Reactions in East Asians: A Population-based Cohort Study
    Clin Trasnla Sci., 14(3): 1002 – 1014 (2021)

  • Ambe K, Suzuki M, Ashikaga T, Tohkin M.
    Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost
    Regul Toxicol Pharmacol., 105019 (2021)

  • Sanagawa A, Hotta Y, Mori N, Tomita N, Kataoka T, Tohkin M, Kimura K.
    BRAF/MEK inhibitor-associated nephrotoxicity in a real-world setting and human kidney cells
    Anticancer Drugs., 1;32(10):1076-1083 (2021)

  • Yamazoe Y, Tohkin M.
    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
    Drug Metab Pharmacokinet., 38:100357 (2021)

  • Kasin Yadunandam Anandam, Padmanabhan Srinivasan, Tomoya Yasujima, Saleh Al-Juburi, Hamid M.
    Said Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).
    Am. J. Physiol. Gastrointest. Liver Physiol., 320, G108-G116 (2021)

  • Nagae, M., Suzuki, K., Yasui, N., Nogi, T., Kohno, T., Hattori, M., and Takagi, L.
    Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization.
    J. Biochem., 169, 555-564 (2021)

  • Tsuneura, Y., Sawahata, M., Itoh, N., Miyajima, R., Mori, D., Kohno, T., Hattori, M.,
    Sobue, A., Nagai, T., Mizoguchi, H., Nabeshoima, T., Ozaki, N., and Yamada, K.
    Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured
    cortical neurons with RELN deletion identified in schizophrenia.
    Neurochem. Int., 144, 104954 (2021)

  • Sawahata, M., Asano, H., Nagai, T., Ito, N., Kohno, T., Nabeshima, T., Hattori, M., and
    Yamada, K.
    Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory
    impairment in mice.
    Pharmacolo. Res. 173, 105832. (2021)